What is Provocholine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Provocholine overview

BRAND NAMES:

  • Provocholine

Generic Names:

  • Provocholine

Uses:

  • Used to help your doctor diagnose bronchial airway hyperreactivity or asthma.

Therapeutic Classes:

  • Diagnostic Agent, Bronchial

Forms:

  • Liquid Under Pressure

How it’s taken:

  • By breathing

What is Provocholine used for?

What form(s) does Provocholine come in

  • Liquid Under Pressure

What are common Provocholine doses?

  • Solution Reconstituted 100MG

Common Provocholine prescriptions

  • Provocholine
    18ml of vial

How to take Provocholine

  • A nurse or other trained health professional will give you this medicine. It is given through oral inhalation using a dosimeter. Your doctor will also use a device, called a spirometer, to check for your lung function.

  • A nurse or other trained health professional will give you this medicine. It is given through oral inhalation using a dosimeter. Your doctor will also use a device, called a spirometer, to check for your lung function.

What to do if you miss a dose of Provocholine

Provocholine contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to methacholine or similar medicines, if you are having an asthma attack or trouble breathing, or if you have a severe decrease in lung function.

Provocholine warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have chronic lung disease (including COPD, tuberculosis, sarcoidosis, or cystic fibrosis), thyroid disease, uncontrolled high blood pressure, aortic aneurysm, epilepsy, ulcer, urinary tract blockage, vagotonia, a respiratory infection, allergic rhinitis without asthma symptoms, or a history of heart attack or stroke. Tell your doctor if you smoke or if you are exposed to air pollutants.

  • This medicine may cause severe constriction of the bronchial airways.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Provocholine interactions

  • Some medicines can affect how methacholine works. Tell your doctor if you are using inhaled cromoglycate, theophylline, beta blockers, or oral or inhaled steroid medicines.

  • Make sure your doctor knows if you have epilepsy, heart disease or heart rhythm problems, circulation problems, or a history of nerve problems or fainting. Tell your doctor if you have a history of ulcers, thyroid problems, constipation, or a blocked urinary tract. Make sure your doctor knows if you are taking medicine to treat myasthenia gravis. Tell your doctor about any other medical problems you may have, or that you have had in the past.

Provocholine side effects

Serious Side Effects

  • Wheezing.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Severe cough, difficulty breathing, noisy breathing, tightness in the chest

Less Serious Side Effects

  • Mild cough, chest tightness, trouble with breathing

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