Rezdiffra (resmetirom) is an oral medication that is used to treat adults with noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis (scarring). This medication, which is available as a tablet that is taken by mouth, should be used in combination with diet and exercise.
Check our best Rezdiffra prices
Rezdiffra overview
BRAND NAMES:
Rezdiffra
Generic Names:
No generic available
Uses:
Treats noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis in adults in combination with diet and exercise
Therapeutic Classes:
Thyroid hormone receptor-beta (THR-beta) agonist
Forms:
Oral tablet
How it’s taken:
By mouth
What is Rezdiffra used for?
Noncirrhotic nonalcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD). NASH, which is not caused by alcohol use, involves a buildup of fat in the liver. This causes inflammation and damage and can also lead to liver scarring. Rezdiffra is a prescription drug approved by the FDA to treat adults with NASH with moderate to advanced liver fibrosis (or scarring). Rezdiffra is used in combination with diet and exercise.
Rezdiffra is not used in people with cirrhosis of the liver (permanent scarring and damage) or decompensated cirrhosis (an acute deterioration of liver function in a person with advanced liver disease).
The FDA has granted Rezdiffra accelerated approval. The FDA’s Accelerated Approval Program allows for earlier approval of drugs that can treat serious conditions. A continued approval may be contingent on the results of ongoing clinical trials.
Expert tips for using Rezdiffra
Rezdiffra is used to treat adults with noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis (scarring).
Rezdiffra should be used in combination with diet and exercise. Consult your healthcare provider for more information about dietary changes and exercises that are appropriate for you.
Take Rezdiffra once daily. You can take it with or without food.
Common side effects include stomach problems, itching, and dizziness. More serious side effects may include liver and gallbladder problems.
Tell your healthcare provider about all the medications you take, as some medications interact with Rezdiffra.
What form(s) does Rezdiffra come in
Oral tablet
60 milligrams (mg)
80 mg
100 mg
What are common Rezdiffra doses?
People who weigh less than 220 pounds will take 80 mg by mouth once daily.
People who weigh 220 pounds or more will take 100 mg by mouth once daily.
People who take Plavix (clopidogrel) will take 60 mg of Rezdiffra once daily if they weigh less than 220 pounds, or 80 mg once daily if they weigh 220 pounds or more.
Rezdiffra can be taken with or without food.
How to take Rezdiffra
Take Rezdiffra by mouth once daily, with or without food. The dosage is based on weight.
Follow your healthcare provider’s instructions regarding diet and exercise.
Keep all appointments with your healthcare provider.
Store Rezdiffra at room temperature, away from direct light, heat, and moisture. Keep the bottle tightly closed when not in use. Keep out of reach and out of sight of children and pets.
What to do if you miss a dose of Rezdiffra
Rezdiffra contraindications
Rezdiffra is not used in anyone under 18 years of age.
You should not take Rezdiffra if you have cirrhosis, decompensated cirrhosis, or moderate to severe liver problems.
If you take certain medications, such as gemfibrozil or cyclosporine, you should not take Rezdiffra.
Rezdiffra warnings
Rezdiffra can cause liver injury. Stop taking this medication and call your doctor right away if you have symptoms such as fatigue, fever, rash, nausea, vomiting, pain in the upper right part of your stomach, or yellowing of the skin or whites of the eyes.
Rezdiffra can cause gallbladder problems, including gallstones or inflammation of the gallbladder or pancreas. Call your doctor immediately if you have nausea, vomiting, fever, or severe stomach pain (that may spread to the back).
Rezdiffra interactions
Before you take Rezdiffra, tell your healthcare provider about all the medications you take, including prescription and OTC drugs, vitamins, and supplements.
You should not take Rezdiffra if you take gemfibrozil or cyclosporine.
If you take a statin such as Crestor (rosuvastatin), Lipitor (atorvastatin), Pravachol (pravastatin), or Zocor (simvastatin), your doctor may need to adjust your statin dosage.
If you take Plavix (clopidogrel), your doctor will lower your dose of Rezdiffra.
Rezdiffra side effects
If you have symptoms of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, get emergency medical help.
Serious side effects
Liver problems
Gallbladder problems
Less serious side effects
Nausea
Vomiting
Diarrhea or constipation
Stomach pain
Itching
Dizziness
Sources:
Rezdiffra prescribing information, Madrigal Pharmaceuticals (2024)
Rezdiffra, Madrigal Pharmaceuticals (2024)
Madrigal Pharmaceuticals announces FDA approval of Rezdiffra™ (resmetirom) for the treatment of patients with noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis, Madrigal Pharmaceuticals (2024)
Non-alcoholic steatohepatitis (NASH), Cedars Sinai
Accelerated approval program, U.S. Food & Drug Administration (2024)
Subscribe to our savings newsletter
Health education, drug info, wellness & more
By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.
