Rheumate is a prescription dietary supplement administered for the clinical dietary management of metabolic effects of methotrexate therapy. Methotrexate (MTX) is considered the primary therapy for people suffering from active rheumatoid arthritis (RA). Rheumate is a brand-name drug, there is no generic version available at the moment. On average, Rheumate costs about $4,764.23 but this total can be lowered using a Rheumate coupon from SingleCare. You can use these free coupons at participating pharmacies nationwide. Pay our lowest price of $9,827.64 for 60, 1 bottle capsules of Rheumate.
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Prices updated: 12/08/2025
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Rheumate is a prescription dietary supplement administered for the clinical dietary management of metabolic effects of methotrexate therapy. Methotrexate (MTX) is considered the primary therapy for people suffering from active rheumatoid arthritis (RA). Rheumate is a brand-name drug, there is no generic version available at the moment. On average, Rheumate costs about $4,764.23 but this total can be lowered using a Rheumate coupon from SingleCare. You can use these free coupons at participating pharmacies nationwide. Pay our lowest price of $9,827.64 for 60, 1 bottle capsules of Rheumate.
Rheumate is a prescription dietary supplement administered for the clinical dietary management of metabolic effects of methotrexate therapy. Methotrexate (MTX) is considered the primary therapy for people suffering from active rheumatoid arthritis (RA). Rheumate is a brand-name drug, there is no generic version available at the moment. On average, Rheumate costs about $4,764.23 but this total can be lowered using a Rheumate coupon from SingleCare. You can use these free coupons at participating pharmacies nationwide. Pay our lowest price of $9,827.64 for 60, 1 bottle capsules of Rheumate.
The price of Rheumate without insurance is $4,764.23 to fill a prescription, but you can use a free SingleCare card and pay as little as $9,827.64 for 60, 1 bottle capsules. You can get discounted prices using your SingleCare savings card at checkout.
You'll have to ask your pharmacist to calculate your Rheumate price with insurance since copays vary by health insurance plan. With SingleCare, Rheumate costs as little as $9,827.64 for 60, 1 bottle capsules, which could be more affordable than your insurance. Take our Rheumate coupons to your local pharmacy to compare prices.
Typically, Medicare does not offer any coverage for Rheumate. Without coverage from Medicare, you may have to pay $4,764.23 for 60, 1 bottle capsules of Rheumate. However, you can pay just $9,827.64 if you use a Rheumate discount card at participating pharmacies like CVS, Walmart, or Walgreens.
Rheumate is manufactured by Primus Pharmaceuticals, inc. There is no generic version Rheumate available.
Rheumate is a prescription medical food for the clinical dietary management of metabolic effects of methotrexate therapy. Similar to multivitamins, minerals, and other drugs, medical foods help manage diseases and require physician supervision. The term “food” speaks to the safety of these products because they must contain only ingredients that have been designated as GRAS (Generally Recognized as Safe), a strict food-safety standard set by the FDA.
Rheumate consists of folate (L-5-methyltetrahydrofolate), curcumin, and vitamin B-12. Curcumin is a powerful antioxidant and addresses methotrexate-induced oxidative stress (too many free radicals in the body). Vitamin B- 12 is added to avoid masking borderline deficiency of B-12 from taking folate supplements.
In patients who are being treated with methotrexate, Rheumate works by replenishing folate by delivering a bioavailable form (L-5-methyltetrahydrofolate) that doesn't need to be converted by the body. This is different from folic acid, which has to be converted to active folate before the body can use it. The folate in this drug is superior because MTX can decrease the conversion of folic acid into folate.
Rheumate should not be used if you have allergies or hypersensitivity to any of the ingredients inthis prescription drug.
Common side effects of Rheumate can include mild diarrhea, nausea, and upset stomach. These are often mild and do not usually require medical attention. Contact your healthcare provider if any of these symptoms persist or worsen.
Get emergency medical attention if you experience an allergic reaction to Rheumate. Signs of an allergic reaction can include rashes, hives, itching, red, swollen, blistered, or peeling skin with or without fever, wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.
All side effects of Rheumate have not been listed here, get medical advice from your doctor about all possible side effects you can experience.
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