What is Tigan: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

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Tigan overview

BRAND NAMES:

  • Tigan, Tigan, Tigan

Generic Names:

  • Trimethobenzamide Hcl

Uses:

  • Treats nausea and vomiting., Treats nausea and vomiting after surgery. Also treats nausea caused by gastroenteritis.

Therapeutic Classes:

  • Antiemetic, Antiemetic

Forms:

  • Injectable, Capsule

How it’s taken:

  • By mouth, By injection

What is Tigan used for?

Tigan comes in the form of an intramuscular solution and is used to treat nausea and vomiting associated with surgery or caused by stomach flu. It works by affecting the area of the brain that stimulates nausea and vomiting. Tigan is not approved for use by anyone younger than 18 years old. Common side effects may include headache, muscle cramps, dizziness and drowsiness.

What form(s) does Tigan come in

  • Injectable

  • Capsule

What are common Tigan doses?

  • Vial 2ML of 100MG/ML

  • Vial 20ML of 100MG/ML

  • Capsule 300MG

Common Tigan prescriptions

  • Tigan
    300mg capsule

  • Tigan
    20ml of 100mg/ml vial

How to take Tigan

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.

  • Drink plenty of fluids while you are using this medicine to keep from becoming dehydrated.

  • A nurse or other trained health professional will give you this medicine. It may also be given by a home health caregiver.

  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.

  • Use a new needle and syringe each time you inject your medicine.

  • Never share your medicine with anyone.

  • Use a new needle and syringe each time you inject your medicine.

  • A nurse or other trained health professional will give you this medicine. It may also be given by a home health caregiver.

  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.

  • Drink plenty of fluids while you are using this medicine to keep from becoming dehydrated.

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.

  • Never share your medicine with anyone.

  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

What to do if you miss a dose of Tigan

  • Keep all medicine away from children.

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose.

  • Do not use extra medicine to make up for a missed dose.

  • If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.

  • Do not use extra medicine to make up for a missed dose.

Tigan contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to trimethobenzamide.

  • You should not use this medicine if you have had an allergic reaction to trimethobenzamide. This medicine should not be given to children unless approved by your doctor.

Tigan warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, brain disease, or Reye syndrome.

  • This medicine may cause the following problems:Extrapyramidal symptoms (muscle and nerve disorders)Liver problems

  • This medicine may make you dizzy, drowsy, or less alert. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Seizures

  • Uncontrollable muscle movements or twitching

  • Yellow skin or eyes

  • Unusual bleeding, bruising, or weakness

  • Make sure your doctor knows if you are pregnant or breastfeeding.

  • Unusual bleeding, bruising, or weakness

  • Yellow skin or eyes

  • Uncontrollable muscle movements or twitching

  • Problems with balance or walking

  • Seizures

  • Lightheadedness or fainting

  • If your vomiting does not stop after taking this medicine for one day, call your doctor.

  • This medicine may make you drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

Tigan interactions

  • If your vomiting does not stop after taking this medicine for one day, call your doctor.

  • Do not drink alcohol while you are using this medicine.

  • Make sure your doctor knows if you are using any medicines that make you sleepy (such as sleeping pills, cold and allergy medicine, narcotic pain relievers, or sedatives).

  • Some medicines can affect how trimethobenzamide works. Tell your doctor if you are using medicine for mental problems.

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Tigan side effects

Serious Side Effects

  • Unusual bleeding, bruising, or weakness

  • Seizures

  • Yellow skin or eyes

  • Hot, dry skin without sweating

  • Lightheadedness or fainting

  • Dark-colored urine or pale stools

  • Problems with balance or walking

  • Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing

  • Uncontrollable muscle movements or twitching

  • Unusual bleeding, bruising, or weakness

  • Yellow skin or eyes

  • Unusual bleeding, bruising, or weakness

  • Twitching or muscle movements you cannot control, problems with balance or walking

  • Trouble swallowing

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Confusion, depression

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Seizures

Less Serious Side Effects

  • Headache

  • Blurred vision

  • Muscle cramps

  • Mild diarrhea

  • Muscle cramps

  • Mild diarrhea

  • Pain, stinging, burning, redness, or swelling where the shot was given

  • Headache

  • Blurred vision

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