What is Tri-Buffered Aspirin: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Tri-Buffered Aspirin overview

BRAND NAMES:

  • Adult Low Dose Aspirin, Ascriptin Regular Strength, Bayer Aspirin Children's, Bayer Aspirin Regimen, Bayer Extra Strength, Bayer Genuine Aspirin, Bayer Low Dose, Bufferin, Durlaza, Ecotrin, Ecpirin, Enteric Aspirin, Genuine Aspirin, Good Neighbor Pharmacy Aspirin, Halfprin

Generic Names:

  • Tri-Buffered Aspirin

Uses:

  • Treats pain, fever, and inflammation. May lower risk of heart attack and stroke.

Therapeutic Classes:

  • Platelet Aggregation Inhibitor, Central Nervous System Agent, Antirheumatic, Antipyretic, Analgesic

Forms:

  • 24 Hour Capsule, Long Acting Tablet, Long Acting Capsule, Gum, Tablet, Chewable Tablet, Fizzy Tablet, Coated Tablet, Delayed Release Capsule

How it’s taken:

  • By mouth

What is Tri-Buffered Aspirin used for?

What form(s) does Tri-Buffered Aspirin come in

  • 24 Hour Capsule

  • Long Acting Tablet

  • Long Acting Capsule

  • Gum

  • Tablet

  • Chewable Tablet

  • Fizzy Tablet

  • Coated Tablet

  • Delayed Release Capsule

What are common Tri-Buffered Aspirin doses?

  • Bottle 100 Tablets

Common Tri-Buffered Aspirin prescriptions

  • Tri-Buffered Aspirin
    100 tablets bottle

How to take Tri-Buffered Aspirin

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: If you miss a dose of Durlaza„¢, skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Gum: Chew completely to make sure you get as much medicine as possible. Drink a full glass (8 ounces) of water after chewing the gum.

  • Swallow the extended-release capsule whole. Do not crush, break, or chew it. Take the capsule with a full glass of water at the same time each day.

  • Chewable tablet: You may chew it completely or swallow it whole.

  • Capsule, tablet, or coated tablet: Swallow whole. Do not crush, break, or chew it.

  • Oral routeIt is best to take this medicine with food or milk.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Chewable tablet: You may chew it completely or swallow it whole.

  • Capsule, tablet, or coated tablet: Swallow whole. Do not crush, break, or chew it.

  • Swallow the extended-release capsule whole. Do not crush, break, or chew it. Take the capsule with a full glass of water at the same time each day.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: If you miss a dose of Durlaza„¢, skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.

  • Oral routeIt is best to take this medicine with food or milk.

  • Gum: Chew completely to make sure you get as much medicine as possible. Drink a full glass (8 ounces) of water after chewing the gum.

What to do if you miss a dose of Tri-Buffered Aspirin

Tri-Buffered Aspirin contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to aspirin or other NSAIDs, or if you have a history of asthma with nasal polyps and rhinitis.

Tri-Buffered Aspirin warnings

  • This medicine may increase your risk for bleeding, including stomach ulcers.

  • Tell your doctor if you have kidney disease, liver disease, high blood pressure, heart disease, or a history of stomach bleeding or ulcers.

  • Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy unless your doctor tells you to.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Do not give aspirin to a child or teenager who has chickenpox or flu symptoms, unless the doctor says it is okay. Aspirin can cause a life-threatening reaction called Reye syndrome.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Tri-Buffered Aspirin interactions

  • Do not give aspirin to a child or teenager who has chickenpox or flu symptoms, unless the doctor says it is okay. Aspirin can cause a life-threatening reaction called Reye syndrome.

  • Do not take Durlaza„¢ 2 hours before or 1 hour after you drink alcohol or take medicines that contain alcohol.

  • This medicine may increase your risk for bleeding, including stomach ulcers.

  • Some foods and medicines can affect how aspirin works. Tell your doctor if you are using any of the following:Dipyridamole, methotrexate, probenecid, sulfinpyrazone, ticlopidineBlood thinner (including clopidogrel, prasugrel, ticagrelor, warfarin)Blood pressure medicineMedicine to treat seizures (including phenytoin, valproic acid)NSAID pain or arthritis medicine (including celecoxib, diclofenac, ibuprofen, naproxen)Steroid medicine (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Tri-Buffered Aspirin side effects

Serious Side Effects

  • Chest tightness, wheezing

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Ringing in the ears

  • Unusual bleeding, bruising, or weakness

  • Bloody or black stools, bloody vomit or vomit that looks like coffee grounds

  • Severe stomach pain