What is Trimethobenzamide: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Trimethobenzamide overview

BRAND NAMES:

  • Tigan

Generic Names:

  • Trimethobenzamide Hcl

Uses:

  • Treats nausea and vomiting after surgery. Also treats nausea caused by gastroenteritis.

Therapeutic Classes:

  • Antiemetic

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Trimethobenzamide used for?

Tigan comes in the form of an intramuscular solution and is used to treat nausea and vomiting associated with surgery or caused by stomach flu. It works by affecting the area of the brain that stimulates nausea and vomiting. Tigan is not approved for use by anyone younger than 18 years old. Common side effects may include headache, muscle cramps, dizziness and drowsiness.

What form(s) does Trimethobenzamide come in

  • Capsule

What are common Trimethobenzamide doses?

  • Capsule 300MG

Common Trimethobenzamide prescriptions

  • Trimethobenzamide HCl
    300mg capsule

How to take Trimethobenzamide

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

What to do if you miss a dose of Trimethobenzamide

  • If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.

  • Do not use extra medicine to make up for a missed dose.

Trimethobenzamide contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to trimethobenzamide.

Trimethobenzamide warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, brain disease, or Reye syndrome.

  • This medicine may cause the following problems:Extrapyramidal symptoms (muscle and nerve disorders)Liver problems

  • This medicine may make you dizzy, drowsy, or less alert. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Seizures

  • Uncontrollable muscle movements or twitching

  • Yellow skin or eyes

  • Unusual bleeding, bruising, or weakness

Trimethobenzamide interactions

  • Some medicines can affect how trimethobenzamide works. Tell your doctor if you are using medicine for mental problems.

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Trimethobenzamide side effects

Serious Side Effects

  • Unusual bleeding, bruising, or weakness

  • Yellow skin or eyes

  • Unusual bleeding, bruising, or weakness

  • Twitching or muscle movements you cannot control, problems with balance or walking

  • Trouble swallowing

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Confusion, depression

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Seizures

Less Serious Side Effects

  • Headache

  • Blurred vision

  • Muscle cramps

  • Mild diarrhea

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