Trazodone is a prescription medication used to treat major depressive disorder. Trazodone works as a serotonin antagonist and reuptake inhibitor (SARI) to relieve symptoms of depression. It may also be used to help treat insomnia and anxiety. Trazodone comes as an oral tablet and is only available as a generic medication. It is known by the brand names Desyrel and Oleptro. The average retail price of Trazodone is $38.28 for 30, 50mg tablets. You may be able to use a SingleCare Trazodone coupon to reduce your cost for Trazodone down to $6.06 for 30, 50mg tablets. SingleCare coupons are free and can be found online or on the mobile app for most brand-name and generic prescription drugs.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Trazodone is a prescription medication used to treat major depressive disorder. Trazodone works as a serotonin antagonist and reuptake inhibitor (SARI) to relieve symptoms of depression. It may also be used to help treat insomnia and anxiety. Trazodone comes as an oral tablet and is only available as a generic medication. It is known by the brand names Desyrel and Oleptro. The average retail price of Trazodone is $38.28 for 30, 50mg tablets. You may be able to use a SingleCare Trazodone coupon to reduce your cost for Trazodone down to $6.06 for 30, 50mg tablets. SingleCare coupons are free and can be found online or on the mobile app for most brand-name and generic prescription drugs.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Trazodone Hcl Retail Price | Trazodone Hcl SingleCare Price |
|---|---|---|
| CVS Pharmacy | $25.26 | $16.50 |
| Walmart | $14.07 | $9.27 |
| Walgreens | $12.00 | $11.31 |
| Kroger Pharmacy | $16.56 | $9.00 |
| Albertsons Pharmacy | $54.94 | $12.50 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Trazodone is a prescription medication used to treat major depressive disorder. Trazodone works as a serotonin antagonist and reuptake inhibitor (SARI) to relieve symptoms of depression. It may also be used to help treat insomnia and anxiety. Trazodone comes as an oral tablet and is only available as a generic medication. It is known by the brand names Desyrel and Oleptro. The average retail price of Trazodone is $38.28 for 30, 50mg tablets. You may be able to use a SingleCare Trazodone coupon to reduce your cost for Trazodone down to $6.06 for 30, 50mg tablets. SingleCare coupons are free and can be found online or on the mobile app for most brand-name and generic prescription drugs.
Trazodone may cost around $38.28 for 30, 50mg tablets without insurance coverage. The cost of Trazodone without insurance can vary based on the pharmacy location and quantity prescribed. Contact your local pharmacy to determine the cost of your medication without insurance. Using a SingleCare Trazodone discount card could help you save on the cash price of your prescription medication. You may be able to pay $6.06 for 30, 50mg tablets when you use a Trazodone discount card at participating neighborhood pharmacies.
The cost of Trazodone with insurance can vary based on the type of insurance coverage plan that you are enrolled in. Different factors can affect the cost with insurance, such as the plan’s formulary and your current coverage stage. If you need to meet your deductible, you may have to pay the full cash price of the medication. Contact your insurance provider directly to find out how much Trazodone costs under your current insurance plan. In some cases, SingleCare may help you save more on Trazodone than your insurance. Compare the cost with your insurance to the price with a savings card before purchasing.
Medicare coverage will vary by plan and prescription. Most Medicare prescription drug plans will help cover the cost of trazodone, as trazodone is a generic prescription drug. Ask a pharmacist to find out if your Medicare Part D or Medicare Advantage plan covers Trazodone. You can also contact your Medicare insurance plan’s provider directly to determine your potential copay or coinsurance amount for Trazodone. If the cost of Trazodone is high with Medicare coverage, you can try a SingleCare prescription discount card to save more. Use a SingleCare savings card today at participating pharmacies to potentially lower your Trazodone costs.
Trazodone is only available as a generic prescription drug. It is manufactured by various companies, including Apotex, Mylan, and Teva Pharmaceuticals. Brand-name versions of this drug include Desyrel and Oleptro. However, the brand-name versions of Trazodone have been discontinued in the United States.
Trazodone is an FDA-approved prescription medication used to treat major depressive disorder. It is approved to be taken daily to help improve symptoms of depression. However, Trazodone can also be used off-label to improve insomnia and anxiety related to depression. Trazodone belongs to a class of drugs called serotonin antagonist and reuptake inhibitors (SARIs).
Trazodone is available in the form of an oral tablet that is usually used once or twice daily after a meal or snack. A healthcare provider will recommend an appropriate dosage based on an assessment of your current medical condition, other drugs you are currently taking, and your response to treatment. For example, if you experience drowsiness and you are taking one dose daily, a healthcare provider may recommend taking your dose at bedtime.
Use this medication exactly as prescribed by your healthcare provider. Do not increase your dosage or use this drug more frequently than recommended. Taking trazodone without guidance from a healthcare provider could increase the risk of side effects.
Continue using this medication even if you feel well. Try taking it at the same time every day to help yourself remember. Do not stop using this medication without consulting your doctor. Withdrawal symptoms, such as agitation, anxiety, and trouble sleeping, can occur if the drug is suddenly stopped.
The most common side effects of trazodone include:
Dizziness
Sleepiness
Tiredness
Diarrhea
Blurred vision
Swelling of the arms or legs
Stuffy nose
Weight loss
Other side effects may include constipation, dry mouth, fatigue, headache, tremors, aches or pains, and weight gain. Consult your doctor or pharmacist if you experience any side effects that persist or worsen. Compared to other antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), trazodone causes fewer sexual side effects. Some people may experience increased sex drive (libido) while taking trazodone.
Trazodone may increase serotonin levels and increase the risk of a serious condition known as serotonin syndrome. The risk of serotonin syndrome is amplified if you are taking other drugs that increase serotonin levels with Trazodone. Seek immediate medical attention if you develop symptoms such as a fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea and vomiting, twitching muscles, unexplained fever, and unusual restlessness.
Other serious side effects that are possible while taking Trazodone include suicidal thoughts or behaviors, heart rhythm problems (arrhythmias), low blood pressure when moving from a lying or sitting position to a standing position (orthostatic hypotension), an increased risk of bleeding, a painful or prolonged erection (priapism), mania or hypomania, angle-closure glaucoma, and low blood sodium levels (hyponatremia).
Serious allergic reactions to this medication are rare. However, you should seek immediate medical attention if you experience symptoms of a serious allergic reaction, such as itching, rash, swelling of the face or throat, severe dizziness, chest tightness, or trouble breathing.
Consult your doctor or healthcare provider for medical advice on the risks and benefits of using Trazodone as this is not a complete list of side effects.
Trazodone is often prescribed off-label to treat short-term insomnia. In other words, trazodone has not been approved by the FDA to treat insomnia. However, studies suggest that trazodone is a useful sleep aid, especially for people who experience insomnia with depression. Trazodone may decrease the time it takes to fall asleep and help you stay asleep longer. Trazodone is usually taken 30 minutes before bed as a sleep aid, and it should only be taken around eight to nine hours before needing to wake up.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved