What is Vyleesi: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Vyleesi overview

BRAND NAMES:

  • Vyleesi

Generic Names:

  • Vyleesi

Uses:

  • Treats low sexual desire disorder in premenopausal women.

Therapeutic Classes:

  • Central Nervous System Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Vyleesi used for?

What form(s) does Vyleesi come in

  • Injectable

What are common Vyleesi doses?

  • Pen 4ML of 1.75MG/0.3ML

  • Pen 1ML of 1.75MG/0.3ML

Common Vyleesi prescriptions

  • Vyleesi
    1ml of 1.75mg/0.3ml pen

  • Vyleesi
    4ml of 1.75mg/0.3ml pen

How to take Vyleesi

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. Inject this medicine at least 45 minutes before a sexual activity.

  • Do not use more than one dose of this medicine within 24 hours. Do not use more than 8 doses per month.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • Injection routeYou will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.

  • Check the liquid in the autoinjector pen. It should be clear or colorless. Do not use the medicine if the liquid is cloudy, discolored, or has particles in it.

  • Injection routeUse a new needle and syringe each time you inject your medicine.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Injection routeIf you store this medicine at home, keep it at room temperature, away from heat, moisture, and direct light.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. Inject this medicine at least 45 minutes before a sexual activity.

  • Do not use more than one dose of this medicine within 24 hours. Do not use more than 8 doses per month.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • Injection routeYou will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.

  • Check the liquid in the autoinjector pen. It should be clear or colorless. Do not use the medicine if the liquid is cloudy, discolored, or has particles in it.

  • Injection routeUse a new needle and syringe each time you inject your medicine.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Injection routeIf you store this medicine at home, keep it at room temperature, away from heat, moisture, and direct light.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

What to do if you miss a dose of Vyleesi

Vyleesi contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to bremelanotide, or if you have heart or blood vessel disease, including an uncontrolled high blood pressure.

Vyleesi warnings

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, or stomach or bowel problems.

  • This medicine may cause high blood pressure and a slow heartbeat.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Vyleesi interactions

  • Some medicines can affect how bremelanotide works. Tell your doctor if you are using naltrexone, medicine to relieve pain (including indomethacin), or medicine to treat an infection.

Vyleesi side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Dizziness, lightheadedness, or fainting

  • Severe or continuing nausea

  • Slow heartbeat

Less Serious Side Effects

  • Darkening of the face, gums, or breasts

  • Feeling of warmth, redness of the skin

  • Headache

  • Pain, itching, burning, swelling, or a lump under your skin where the shot was given

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