Key takeaways
Xiidra is a prescription eye drop medication used to treat dry eye disease.
As a brand-name medication, Xiidra eye drops may be expensive.
Cost-saving options include using a SingleCare prescription discount card, considering generic alternatives, or enrolling in patient assistance programs.
Xiidra is a brand-name prescription eye drop medication that treats dry eye disease. Unlike over-the-counter lubricant eye drops, the active ingredient in Xiidra, lifitegrast, reduces inflammation that may be causing dry eye and its symptoms. While Xiidra can be an effective treatment for dry eye disease, its cost can be a barrier for some people, especially those without insurance coverage. Cost-saving options are available through various discounts, Xiidra coupons, or assistance programs that help reduce the out-of-pocket cost for the medication.
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How much does Xiidra cost without insurance?
Xiidra comes in single-use containers, and the recommended dosage is one drop in each eye twice daily. Therefore, a monthly supply consists of 60 vials. The cash or retail price for Xiidra can vary by pharmacy, but the average cost without insurance is $1,018 for 60 single-use vials of 5% solution. That’s enough medication for 30 days of doses if both eyes are being treated. Therefore, the annual cost of using Xiidra without insurance could exceed $12,000.
Some patients might find financial assistance through manufacturer programs or consider alternatives such as Restasis, another brand-name prescription medication with similar approved uses. When considering alternatives, it’s recommended to consult a healthcare provider, who can recommend the most appropriate treatment based on your budget and needs.
How much does generic Xiidra cost?
Xiidra is a brand-name medication. It doesn’t currently come in a generic version, and its brand-name patent isn’t set to expire until 2033. Without insurance, the brand-name version costs $1,018 for 60 single-use vials of 5% solution, which is a 30-day supply.
Compare Xiidra prices to related drugs |
|||
|---|---|---|---|
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
| Xiidra
(lifitegrast) |
$1,018 for 60 single-use containers of 5% solution | $726 for 60 single-use containers of 5% solution of brand-name Xiidra at Kroger | See latest prices |
| Cequa
(cyclosporine) |
$887 for 1, 60 single-use vials box of 0.09% solution | $639 for 1, 60 single-use vials box of 0.09% solution of brand-name Cequa at Kroger | See latest prices |
| Restasis (cyclosporine) | $409 for 1, 30 single-use vials box | $64 for 1, 30 single-use vials box of generic Restasis at Publix | See latest prices |
| Eysuvis
(loteprednol) |
$691 for 1, 8.3 mL of 0.25% bottle | $463 for 1, 8.3 mL of 0.25% bottle of brand-name Eysuvis at Kroger | See latest prices |
| Tyrvaya
(varenicline tartrate) |
$949 for 8.4 mL of 0.03 mg/act solution | $653 for 8.4 mL of 0.03 mg/act solution of brand-name Tyrvaya at Kroger | See latest prices |
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Xiidra costs by dose
Xiidra is only available as a 5% solution. However, it is available in different quantities, and the price can vary depending on the prescribed quantity. The following table highlights the cost of Xiidra by quantity.
Compare Xiidra prices by quantity |
|
|---|---|
| Quantity | SingleCare price of brand-name Xiidra |
| 5 single-use containers of 5% solution | $62 at Kroger |
| 10 single-use containers of 5% solution | $123 at Kroger |
| 30 single-use containers of 5% solution | $364 at Kroger |
| 60 single-use containers of 5% solution | $726 at Kroger |
| 120 single-use containers of 5% solution | $1,451 at Kroger |
| 180 single-use containers of 5% solution | $2,175 at Kroger |
Is Xiidra covered by insurance?
Insurance coverage for Xiidra can vary. According to the manufacturer, most people with health insurance are covered, and many insurance plans do not require step therapy. There may be out-of-pocket expenses, such as a copay or coinsurance amount. Those who still need to meet their deductible may have to pay the full retail price of the drug.
Medicare coverage for prescription drugs is often provided under Part D plans, which are offered by private companies approved by Medicare. Many prescription drug plans include Xiidra, and most covered Medicare patients don’t need prior authorization, but coverage is not guaranteed and depends on the specific Medicare Part D plan formulary. Similarly, Medicaid coverage for prescription drugs is managed at the state level and may cover Xiidra, though coverage can vary by state.
How to get Xiidra covered by insurance
If your insurance company doesn’t cover Xiidra, talk to your healthcare provider. You typically need a valid prescription for medications to be covered by your plan. Some insurance companies may also require prior authorization, a process they use to ensure a medication is necessary, before they cover Xiidra. If your insurance plan doesn’t cover Xiidra, talk to your healthcare provider. They can suggest resources that can help lower the cost of the drug or recommend alternative medications.
How to get Xiidra without insurance
Purchasing prescription drugs like Xiidra without insurance can sometimes be challenging. However, savings options like prescription savings cards and coupons may help reduce Xiidra prices. Here are some ways to potentially reduce the costs:
1. Use prescription discount cards
A SingleCare discount card can help reduce the cost of Xiidra at participating pharmacies. Check with your pharmacy to see if they’ll accept SingleCare savings cards and coupons. SingleCare is free to use and available to everyone. Registered members can save even more, and it’s fast and free to join.
Save up to 80% on Xiidra with SingleCare
Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
2. Consider generic or comparable medications
Generic medications or similar drugs offer more affordable alternatives. While there is no generic Xiidra available, talking to a healthcare provider about alternatives can be a first step. They can advise on other medications that might not cause adverse effects and are less costly yet effective in treating dry eye syndrome. For example, cyclosporine, the active ingredient in a similar brand-name medication called Restasis, is a lower-cost generic used to treat dry eye syndrome.
3. Compare prices among pharmacies
Not all pharmacies charge the same price. Therefore, compare the price of Xiidra eye drops across different pharmacies. Some might offer lower prices or run special promotions that help reduce prescription drug costs.
4. Enroll in prescription assistance programs
Assistance programs may be available for eligible patients who have trouble paying for prescription drugs. Individuals experiencing financial hardship who meet the eligibility requirements may receive Xiidra at no cost.
5. Request a 90-day supply
Obtaining a 90-day supply of Xiidra may be more cost-effective than a 30-day supply, as buying in bulk may reduce the per-unit cost. A pharmacist may be able to dispense a 90-day supply. However, you can also consult a healthcare professional for medical advice to explore this option and adjust your prescription accordingly.
6. Check eligibility for government aid
Some government programs may offer assistance for prescription medications. Therefore, it’s worth checking whether programs like Medicaid have provisions for medications like Xiidra, especially for people with low income or certain disabilities.
RELATED: How to save on Xiidra prescriptions
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The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Aug. 5, 2026. Prices vary by pharmacy. Visit our coupon page for updated drug prices at pharmacies near you.
- Xiidra lifitegrast solution/drops prescribing information, DailyMed (NIH National Library of Medicine) (2024)
- Restasis cyclosporine emulsion prescribing information, DailyMed (NIH National Library of Medicine) (2024)
- Paragraph IV patent certifications, U.S. Food and Drug Administration (FDA) (2026)
- Xiidra HCP, Bausch + Lomb (2026)
- Medically accurate: SingleCare’s Medical Review Board analyzes all of our content to confirm it’s in line with current medical advice.
- Evidence-based: Our content is sourced from reputable U.S.-based healthcare professionals and peer-reviewed research.
- Trustworthy: All of SingleCare’s content goes through a multi-phase review process by our writers, editors, and Medical Board in order to provide clear and credible information.