Zoloft is an FDA-approved antidepressant that is used to treat depression and anxiety. It can also be used to treat obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder. Zoloft belongs to a group of medications called selective serotonin reuptake inhibitors (SSRIs). The generic version of Zoloft is sertraline hydrochloride. The cash price of Zoloft is about $543.85 for 30, 50mg tablets. You can use SingleCare Zoloft coupons to potentially save and pay a lower price of $8.72 for 30, 50mg tablets of generic Zoloft.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Zoloft is an FDA-approved antidepressant that is used to treat depression and anxiety. It can also be used to treat obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder. Zoloft belongs to a group of medications called selective serotonin reuptake inhibitors (SSRIs). The generic version of Zoloft is sertraline hydrochloride. The cash price of Zoloft is about $543.85 for 30, 50mg tablets. You can use SingleCare Zoloft coupons to potentially save and pay a lower price of $8.72 for 30, 50mg tablets of generic Zoloft.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Zoloft Retail Price | Sertraline Hcl Retail Price | Sertraline Hcl SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $528.90 | $34.95 | $33.86 |
| Walmart | $520.50 | $14.10 | $13.80 |
| Walgreens | $533.10 | $39.90 | $28.49 |
| Kroger Pharmacy | $550.50 | $33.72 | $11.20 |
| Albertsons Pharmacy | - | $61.90 | $14.29 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Zoloft is an FDA-approved antidepressant that is used to treat depression and anxiety. It can also be used to treat obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder. Zoloft belongs to a group of medications called selective serotonin reuptake inhibitors (SSRIs). The generic version of Zoloft is sertraline hydrochloride. The cash price of Zoloft is about $543.85 for 30, 50mg tablets. You can use SingleCare Zoloft coupons to potentially save and pay a lower price of $8.72 for 30, 50mg tablets of generic Zoloft.
Without insurance, the retail price of Zoloft is around $543.85 for 30, 50mg tablets. You can use a free SingleCare savings card or Zoloft coupon and pay as little as $8.72 for 30, 50mg tablets of generic Zoloft at local pharmacies like CVS Pharmacy, Walmart, and Walgreens. You can also ask your pharmacist about sertraline, the generic version of Zoloft, which may be cheaper than the brand name.
You can ask your pharmacist to calculate your Zoloft price with insurance since copays vary by health insurance plan. With SingleCare, Zoloft may cost just $8.72 for 30, 50mg tablets of generic Zoloft, which could be more affordable than your insurance. Use a SingleCare Zoloft coupon during your next visit to your local pharmacy and compare pricing.
Medicare does not typically cover branded Zoloft, but you can use a SingleCare discount card to save on this expensive prescription drug. With SingleCare, you could pay as little as $8.72 for 30, 50mg tablets of generic Zoloft. Savings can be redeemed at participating pharmacies across the United States.
Zoloft is the brand-name prescription drug. Sertraline hydrochloride is the generic version of Zoloft.
Zoloft is an FDA-approved antidepressant medication used to treat major depressive disorder (MDD), obsessive compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic attacks, post-traumatic stress disorder (PTSD), and social anxiety disorder. It belongs to a group of medicines called selective serotonin reuptake inhibitors (SSRIs). Sertraline hydrochloride is the generic version of Zoloft. Zoloft works by increasing the amount of serotonin in the brain, which can help regulate mood and improve feelings of well-being.
Zoloft is available as an oral tablet and a liquid solution. Oral tablets come in strengths of 25 mg, 50 mg, and 100 mg. The oral solution comes in a strength of 20 mg/mL. Zoloft is usually taken once daily; however, it should only be used as directed by your doctor.
Do not take Zoloft within 14 days before or after you use an MAO inhibitor, as a dangerous drug interaction could take place. You should consult with your doctor if you are or plan to become pregnant while taking Zoloft. Also ask a healthcare provider before taking Zoloft while breastfeeding.
Zoloft should not be prescribed to those younger than 18 years old without the medical advice of a doctor. Tell your doctor about other medical conditions you may have, such as heart disease, liver or kidney disease, high blood pressure, seizures, or bleeding problems before taking Zoloft. Consult your doctor if you have a history of bipolar disorder as the use of Zoloft could increase the risk of mania or hypomania.
The use of Zoloft has been linked to side effects such as nausea, indigestion, diarrhea, decreased appetite, and tremors. Other side effects of Zoloft include increased sweating, ejaculation problems, and decreased libido. This may not be a complete list of side effects.
You should seek medical attention right away if you experience blurred vision, seizures, manic episodes, or symptoms of low sodium levels in the body, such as confusion, weakness, and unsteadiness. You should also seek immediate medical attention if you experience an allergic reaction such as hives, swelling of the face, lips, and mouth, or trouble breathing.
Talk to your pharmacist or healthcare professional about other possible risks and benefits associated with Zoloft before starting treatment.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved