What is Zonalon: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Zonalon overview

BRAND NAMES:

  • Prudoxin, Zonalon

Generic Names:

  • Doxepin Hcl

Uses:

  • Reduces itching caused by skin diseases such as atopic dermatitis or lichen simplex chronicus.

Therapeutic Classes:

  • Dermatological Agent

Forms:

  • Cream

How it’s taken:

  • On the skin

What is Zonalon used for?

What form(s) does Zonalon come in

  • Cream

What are common Zonalon doses?

  • Tube 30GM of 5%

  • Tube 45GM of 5%

Common Zonalon prescriptions

  • Zonalon
    30gm of 5% tube

  • Zonalon
    45gm of 5% tube

  • Zonalon
    30gm of 5% tube of cream

  • Zonalon
    45gm of 5% tube of cream

How to take Zonalon

  • Topical application routeApply a thin layer of the medicine to the affected area. Rub it in gently.

  • Apply a thin layer of this medicine each time you use it.

  • Topical application routeWash your hands with soap and water before and after you use this medicine.

  • Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

  • Topical application routeWash your hands with soap and water before and after you use this medicine.

  • Topical application routeApply a thin layer of the medicine to the affected area. Rub it in gently.

  • Apply a thin layer of this medicine each time you use it.

  • Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

What to do if you miss a dose of Zonalon

  • Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Topical application routeAsk your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Zonalon contraindications

  • You should not use this medicine if you have had an allergic reaction to doxepin, or if you have glaucoma or problems urinating.

Zonalon warnings

  • Make sure your doctor knows if you are pregnant or breast feeding.

  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

  • Drowsiness or lightheadedness or fainting.

  • Irregular heartbeat

  • Swelling in your feet, arms, or body.

Zonalon interactions

  • There are many other drugs that can interact with doxepin. Make sure your doctor knows about all other medicines you are using.

  • Make sure your doctor knows if you are using MAO inhibitors such as Eldepryl®, Marplan®, Nardil®, or Parnate®, or allergy medicines.

  • Make sure your doctor knows if you are using medicine for depression such as trazadone, Clexa®, Prozac®, Paxil®, or Zoloft®, or amitriptyline, Norpramin®, or Vivactil®.

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Zonalon side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Confusion, hallucinations, severe weakness, vomiting, muscle stiffness.

  • Drowsiness or lightheadedness or fainting.

  • Irregular heartbeat

  • Swelling in your feet, arms, or body.

  • Redness, pain, swelling, or itching on site of cream application.

  • Worsening of you skin condition.

Less Serious Side Effects

  • Burning or stinging of your skin where the medicine in applied.

  • Nervousness, anxiety.

  • Worsening of you skin condition.

  • Redness, pain, swelling, or itching on site of cream application.

  • Headache or tiredness.

  • Change in taste or dryness of your mouth.

  • Numbness in your tongue.

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