How much is Valacyclovir HCl (Valtrex) without insurance?

In this article:

• How much does valacyclovir HCl cost without insurance?
• Is valacyclovir HCl covered by insurance?
• How to get valacyclovir HCl without insurance

In this article

• How much does valacyclovir HCl cost without insurance?
• Is valacyclovir HCl covered by insurance?
• How to get valacyclovir HCl without insurance

Valacyclovir is a generic prescription antiviral medication FDA-approved to treat herpes simplex virus infections (HSV) and treat varicella-zoster virus (VZV) infections. These include cold sores, genital herpes, chickenpox, and shingles. Valacyclovir tablets typically cost about $7 per tablet. People on suppressive therapy could pay $211 monthly for their daily 500 mg doses.

Related: Valacyclovir HCl dosage

How much does valacyclovir HCl cost without insurance?

Valacyclovir costs more than other common generic drugs. For a prescription of 30, 500 mg oral tablets, the full cost averages $211 or $7 per tablet. For most infections, prescriptions will involve three to 20 tablets, so expect to pay $21 to $140. Treatment is limited to three to 10 days, but some people may take daily doses for weeks or months to prevent genital herpes outbreaks.

If pricing is a concern, ask the prescribing healthcare professional about other antiviral prescription medications that treat herpes infections, including generic Zovirax (acyclovir). For 60, 400 mg acyclovir tablets, the retail price is about $77. However, acyclovir must be taken four to five times daily, so 60 tablets is a 12- or 15-day supply. For genital herpes, consider asking a healthcare provider for a topical antiviral cream. It may cost more, but the adverse effects are milder.

For people without health insurance coverage, a SingleCare prescription discount card may be the cheapest alternative. While the normal retail price of valacyclovir is $211 for 30 tablets, the lowest SingleCare discount price for the same purchase is only $11 at Kroger.

RELATED: Acyclovir vs. valacyclovir: Differences, similarities, and which is better

Compare valacyclovir HCl (Valtrex) prices to related drugs
Drug name	Price without insurance of brand-name drug	SingleCare price	Savings options
Valacyclovir HCl	$211 per 30, 500 mg tablets	$11 per 30, 500 mg tablets of generic valacyclovir at Kroger	See latest prices
Brand-name valacyclovir HCl (Valtrex)	$511 per 30, 500 mg tablets	$396 per 30, 500 mg tablets of brand-name Valtrex at Kroger	See latest prices
Acyclovir	$102 per 60, 400 mg tablets	$9 per 60, 400 mg tablets of generic acyclovir at Kroger	See latest prices
Famciclovir	$241 per 21, 500 mg tablets	$24 per 21, 500 mg tablets of generic famciclovir at Kroger	See latest prices
Zovirax (acyclovir)	$599 per 1, 5 gm of 5% cream	$25 per 1, 5 gm of 5% cream of generic acyclovir at CVS Pharmacy	See latest prices
Xerese  (acyclovir-hydrocortisone)	$1,660 per 1, 5 gm of 5%-1% cream	$1,323 per 1, 5 gm of 5%-1% cream of brand-name Xerese at Kroger	See latest prices
Denavir (penciclovir)	$1,055 per 1, 5 gm of 1% cream	$151 per 1, 5 gm of 1% cream of generic penciclovir at CVS Pharmacy	See latest prices

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of 12/10/2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.

RELATED: Valtrex alternatives: What can I take instead of Valtrex?

Valacyclovir HCl costs by dose

Valacyclovir is taken in 500 mg, 1 gm, or 2 gm doses, so it comes in two dosage strengths. The 1 gm tablet costs more than the 500 mg tablet, but not by much. The final out-of-pocket cost will depend on the quantity prescribed. In some cases, only one dose is required. Other infections may require two or three doses a day for three to 10 days. Some people may need to take valacyclovir indefinitely.

Compare valacyclovir HCl prices by strength
(per 30 tablets)
Strength	SingleCare price of brand-name valacyclovir HCl	SingleCare price of generic valacyclovir HCl
500 mg of valacyclovir HCl	$396 at Kroger	$11 at Kroger
1 g of valacyclovir HCl	$622 at Kroger	$17 at Kroger
See our lowest price for valacyclovir HCl without insurance

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of 12/10/2025.

Is valacyclovir HCl covered by insurance?

People with health insurance or Medicaid are usually covered for valacyclovir. Medicare drug plans generally cover valacyclovir, but there may be exceptions. Insurance plans generally place valacyclovir in their lowest copay tiers, so the cost should be low. However, the final out-of-pocket cost will be determined by other factors, such as deductibles or coverage gaps. 

How to get valacyclovir HCl without insurance

Without insurance, generic valacyclovir costs $7 per 500 mg tablet, a cost that could easily add up when treatment goes on for several days. Patient assistance programs may help with a brand-name Valtrex prescription, but they are not usually offered for generic drugs like valacyclovir. Fortunately, some tremendous cost-savings exist on generics, even higher-priced ones like valacyclovir. For instance, a SingleCare savings card could reduce the retail price of valacyclovir and other prescription meds by more than 80%. 

1. Use a prescription discount coupon from SingleCare

The lowest SingleCare cash price for 30 tablets of valacyclovir is $11 at Kroger, a savings of $200 off the average retail price at participating pharmacies. Make sure to sign up for SingleCare’s bonus loyalty program to earn additional savings on future purchases or refills.

2. Shop for the lowest price at local pharmacies

By comparing drugstore prices, you could find that the lowest retail price for 30 valacyclovir tablets is half the highest pharmacy price. The savings can be considerable. 

3. Find local 340B providers, community clinics, or reproductive health clinics

Generic medications may be available at community clinics or 340B providers at a discount. Genital herpes is considered a sexually transmitted disease (STD), so valacyclovir tablets may be free at STD or reproductive health clinics. Talk to a local healthcare official for help.

4. Switch to acyclovir

Acyclovir is the active form of valacyclovir, so the generic version of acyclovir is a lower-priced option. It’s just as effective as valacyclovir and has the same common side effects. It also comes in other formats other than oral tablets, such as topical formulations. The downside is that acyclovir requires more frequent dosing. 

5. Ask the prescriber about symptomatic treatment

Herpes flare-ups in healthy people typically go away on their own. Antiviral drugs like valacyclovir can speed up the process. If cost is a barrier, ask the prescriber for medical advice about over-the-counter drugs or OTC supplements that can relieve symptoms while the body fights off the flare-up. If the flare is severe, your doctor may request that you go forward with the antiviral treatment.

The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of 12/10/2025. Prices vary by pharmacy. Visit our valacyclovir HCl coupon page for updated valacyclovir HCl prices near you.