Rexulti generic availability and alternatives

In this article:

• Rexulti generic availability
• What are the differences between brand-name and generic Rexulti?
• Rexulti (brexpiprazole) at a glance
• How much is generic Rexulti?
• Rexulti prices
• Is Rexulti covered by insurance?
• How do you get Rexulti covered by insurance?
• Generic alternatives to Rexulti
• Expert takeaway

In this article

• Rexulti generic availability
• What are the differences between brand-name and generic Rexulti?
• Rexulti (brexpiprazole) at a glance
• How much is generic Rexulti?
• Rexulti prices
• Is Rexulti covered by insurance?
• How do you get Rexulti covered by insurance?
• Generic alternatives to Rexulti
• Expert takeaway

Rexulti (brexpiprazole) is a prescription medication that’s part of a drug class called atypical antipsychotic drugs, or second-generation antipsychotics. Currently, there is no Rexulti generic available in the U.S. Although the Food and Drug Administration (FDA) has approved generic brexpiprazole, the Rexulti generic name, it is not yet on the market. Brand-name Rexulti is under patent protection until April 2026, which affects when generic Rexulti may become available.

What are the differences between brand-name and generic Rexulti?

Although there is no generic Rexulti available at this time, generic drugs contain the same active ingredient and work the same way as their brand-name counterparts. The FDA requires that generics be bioequivalent, which means that the generic drug results in the same blood levels in the body over the same period of time as the brand. One important difference is the price: Generics often cost up to 80% less than brand-name drugs. The table below outlines some important information about Rexulti. 

How much is generic Rexulti?

Generic Rexulti is not yet available. Without health insurance or discounts, brand-name Rexulti costs about $2,073 for 30, 1 mg tablets (a one-month supply), on average. You can use a free SingleCare coupon to pay $1,471 for this prescription, depending on your choice of pharmacy.  

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of Feb. 17, 2026. 

Is Rexulti covered by insurance?

Insurance coverage varies, so you can contact your insurance plan directly or check the most recent formulary to find out more about Rexulti coverage. According to Rexulti’s manufacturer, Otsuka America Pharmaceutical, Inc.: 

• People with commercial insurance, such as employer-sponsored coverage, pay an average of $31 per month for Rexulti. Additionally, a Rexulti Savings Card is available for those who qualify.
• Individuals with Medicare prescription coverage pay an average of $21 per month, depending on what coverage stage they are in.
• Medicaid coverage varies by state, but Rexulti’s manufacturer reports that patients with Medicaid pay an average of $3 per month. 

If you are paying out of pocket, you can read more about paying for Rexulti without insurance here. 

How do you get Rexulti covered by insurance?

Many insurance plans cover Rexulti. Your healthcare provider can send a prescription to your pharmacy, and the pharmacy staff will process the claim and let you know if the drug is covered or if your insurance plan requires prior authorization. 

If you want to check your coverage first, you can call your insurance provider or log in to your plan’s secure website to view the most recent online formulary. 

Generic alternatives to Rexulti

If you are interested in switching to a generic Rexulti alternative, the best way to do so is to consult your healthcare provider for medical advice. Only your healthcare provider can decide which medication is appropriate for you, based on individual factors such as the condition being treated, your medical history, and other medicines you take. Some examples of generic FDA-approved Rexulti alternatives include:

• Aripiprazole (generic Abilify)
• Lurasidone (generic Latuda)
• Quetiapine (generic Seroquel)
• Risperidone (generic Risperdal)
• Ziprasidone (generic Geodon)

Expert takeaway 

“A generic version of Rexulti is not yet available. There are various savings options that you can discuss with your healthcare provider,” says Karen Berger, Pharm.D., member of the SingleCare Medical Board. “However, if Rexulti is still too expensive, your provider may be able to recommend a similar, lower-cost generic alternative.”