Entresto savings guide

In this article:

• How to save money on Entresto
• Is there a cheaper alternative to Entresto?

In this article

• How to save money on Entresto
• Is there a cheaper alternative to Entresto?

Entresto is a brand-name prescription medication that contains a combination of drugs, sacubitril and valsartan. “Entresto is recommended as a first-line treatment to treat heart failure in adults,” explains Richard Linsky, MD, a physician in New York City. ”Entresto has been shown to lower the risk of cardiovascular-related deaths and heart failure-related hospitalization.”

If your healthcare provider has prescribed Entresto, you may be worried about how you can afford it. Read on for all the ways to save money on Entresto, so you can continue your treatment without breaking the bank.

How much does Entresto cost without insurance?

The average retail cost of brand-name Entresto is around $969 for 60, 24-26 mg tablets, which is a 30-day supply of the lowest dose. The typical dosage is one tablet taken twice daily. Because heart failure medications are prescribed for months to years, patients without insurance could pay more than $11,600 per year for brand-name Entresto.

Is there a generic for Entresto?

Fortunately, you can cut the cost of Entresto in half simply by switching to generic Entresto. Like brand-name Entresto, generic Entresto combines sacubitril with valsartan and is FDA-approved to reduce the risk of cardiovascular events in patients with chronic heart failure.

Brand vs. generic Entresto cost comparison
Brand vs. generic	Per pill	Per month	Per year
Brand-name Entresto price without insurance	$16.15 per 24-26 mg tablet	$969 for 60, 24-26 mg tablets	$11,600 for monthly refills of 60, 24-26 mg tablets
Generic Entresto price without insurance	$8.35 per 24-26 mg tablet	$501 for 60, 24-26 mg tablets	$6,012 for monthly refills of 60, 24-26 mg tablets

How to save money on Entresto

There are several ways to save on your Entresto prescription, whether you have insurance, Medicare, or no coverage at all. Here’s a quick reference guide to some Entresto saving options.

Quick Entresto savings options
Savings methods	Estimated monthly cost	Eligibility	Notes
Manufacturer copay card + commercial insurance	As low as $10	Must have commercial insurance	Annual max benefit ~$4,100; not valid for Medicare, Medicaid, or other government insurance
Medicare Part D	$25-$30	Medicare beneficiaries	Copay depends on formulary tier and deductible status
Medicare Extra Help	$0–$10	Low-income Medicare beneficiaries	Automatically applies to eligible individuals
SingleCare coupon	As low as $48 for generic Entresto	Anyone with a valid prescription	Savings vary by pharmacy, dose, and location

1. SingleCare free coupons

SingleCare is an easy, free option to save on Entresto and thousands of other medications. To use an Entresto coupon from SingleCare, enter your prescription details (brand/generic, strength, and number of tablets you’re prescribed) and your zip code. Then choose the pharmacy near you with the best price and click the “Get coupon” button to receive a coupon you can text to yourself or print to show your pharmacist. You can also download the SingleCare app, which is available on iOS and Android. 

2. Compare prices at different pharmacies

You can save hundreds of dollars on your prescription by comparing prices at local pharmacies before filling your prescription. For example, in Hampton, VA, generic Entresto costs $48 at CVS but $445 at Walmart for the same amount of 60, 24-26 mg tablets. Use SingleCare to compare prices before you fill your prescription.

3. Health insurance and Medicare coverage

Up to 80% of commercial and private insurance plans cover Entresto, according to Novartis, the manufacturer, and most Medicare Part D plans cover Entresto. Health insurance can reduce the cost of Entresto, but the cost with insurance depends on your plan’s deductible and the copay set by the plan’s formulary. 

Entresto was one of the first 10 drugs selected for Medicare drug price negotiations due to the Inflation Reduction Act in 2022. At the time, 521,000 Medicare enrollees were taking Entresto. The negotiated price for a 30-day supply of Entresto with Medicare in 2026 is $295, a 53% discount from the 2023 list price.

4. Entresto copay card

Novartis offers an Entresto manufacturer coupon that lowers the cost of Entresto with commercial insurance to as low as $10. The annual limit of this savings is $4,100. However, you must have health insurance and complete an application to be eligible for the Entresto $10 copay card. It is not available to those with government-sponsored health insurance. Ineligible government-sponsored plans include:

• Medicare, such as Medicare Advantage, Medicare Supplement, and Medigap plans
• Medicaid
• Veterans Affairs and the Department of Defense plans
• TRICARE

5. Medicare Extra Help

The Medicare Extra Help program helps people with limited income and resources pay for prescriptions like Entresto. Some people qualify for the Extra Help program automatically, while others need to apply. 

Individuals who receive any of the following qualify for Extra Help automatically: 

• Full Medicaid coverage
• State assistance for Part B premiums 
• Social Security Supplemental Security Income (SSI) benefits 

Once you’re eligible for Extra Help, you’ll receive a letter with details. If you don’t automatically qualify, you can apply online or call the Social Security Administration at 800-772-1213 or 800-325-0778 (TTY) Monday through Friday from 7 a.m. to 7 p.m. local time.

Is there a cheaper alternative to Entresto?

Entresto is the only ARNI medication. There are no available alternatives within the same drug class. However, there are some Entresto alternatives to consider for heart failure. These include:

• ACE inhibitors, like enalapril
• Angiotensin II receptor blockers (ARBs), like valsartan
• Beta blockers, like carvedilol
• Aldosterone antagonists, like spironolactone or eplerenone
• Isosorbide dinitrate and hydralazine
• Ivabradin
• Sodium-glucose cotransporter 2 (SGLT2) inhibitors, like Farxiga or Jardiance

RELATED: Jardiance vs. Entresto

You can use SingleCare coupons on all of these Entresto alternatives. Consult your healthcare provider for more information and medical advice about your treatment.

Whether through alternative medications, a manufacturer’s assistance program, or an Entresto savings card from SingleCare, there are ways to make heart failure treatment more affordable. Take advantage of all the possibilities available to reduce the cost of your medication.