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Key takeaways
Medicare prescription drug plans, including Part D plans and Medicare Advantage (Part C), will typically cover brand-name Entresto, with copays being about $25 per month.
The reasons Entresto can be expensive include its newer, brand-name status, existing patents, pharmacy pricing, and health insurance coverage.
Medicare beneficiaries can save money on their Entresto prescription by comparing Medicare drug plans annually, enrolling in Medicare Extra Help, using coupons, buying from a mail-order pharmacy, and exploring state assistance programs.
Entresto (sacubitril and valsartan) is a first-in-class angiotensin receptor-eprilysin inhibitor (ARNi) approved by the U.S. Food and Drug Administration (FDA) to treat chronic heart failure in adults—particularly in people with a left ventricular ejection fraction (LVEF) that’s below normal. The prescription drug is also prescribed to children aged one year and older for symptomatic heart failure with systemic left ventricular systolic dysfunction. The cost of Entresto for Medicare patients averages about $25-$30 for a 30-day supply.
Why is Entresto so expensive?
Like many prescription medications on the market, Entresto can be expensive without insurance coverage. The primary reason for the high price tag is that it’s a relatively new brand-name drug. Entresto—developed by Novartis—was FDA-approved for public use in July 2015 and granted a patent that prevented other pharmaceutical companies from developing generic formulations until July 2025. Now, MSN Pharmaceuticals and Torrent have their generic versions of the brand-name heart medication.
“All new medications that come out are expensive because of the patent that they can have when they first come out,” explains Joyce Oen-Hsiao, MD, FACC, a board-certified cardiologist and associate professor of medicine (cardiovascular medicine) at Yale School of Medicine in New Haven, Connecticut. “When a pharmaceutical company first develops a new medication to be used for a particular disease, it is initially only sold under the brand name because it is covered under patent protection. The pharmaceutical company has a patent on the medication to manufacture, market, and make a profit on the medication.”
Another reason for Entresto’s high price tag is your health insurance provider. “Insurance companies decide if they want to put the medications on their formulary and then also choose what tier the medication is covered at,” Dr. Oen-Hsiao explains. “Generally, higher-tier medications will require a higherco-payment or co-insurance from the patient. If the patient has a deductible as part of their insurance plan, they may have to pay the entire cost of the medication at the beginning of the year.”
Does Medicare cover Entresto?
In most cases, Medicare Part D will cover Entresto. “Most Medicare Part D and Medicare Advantage drug plans cover Entresto,” says James Lyons, MD, a board-certified physician in hospitalist care, emergency medicine, psychiatry, and family medicine, and medical consultant for Synergy Houses. “Typical annual out-of-pocket cost for beneficiaries averages around $300-$400, though this varies by plan and coverage stage. Entresto is not covered under Original Medicare Parts A and B unless the drug is administered in a hospital or physician’s office.”
How much does Entresto cost with Medicare?
According to the Centers for Medicare & Medicaid Services (CMS), beneficiaries will have an out-of-pocket cost of $295 for Entresto in 2026. This price averages about $25 per month for a 30-day supply. “Entresto is one of the first drugs selected for Medicare price negotiation, which may help lower drug costs in the coming years,” Dr. Lyons says. “While not a cure, it’s a cornerstone therapy that can greatly improve quality of life when used as part of a comprehensive heart-failure treatment plan.”
Several factors can influence what you’ll be paying out of pocket each month for your Entresto prescription. “Out-of-pocket cost depends on formulary, drug tier, deductible status, pharmacy pricing, and eligibility for copay or patient-assistance programs,” Dr. Lyons says.
Strategies to reduce Entresto costs on Medicare
If you’re on Medicare and are paying high out-of-pocket costs for Entresto, here are some ways you can save some money:
Compare Medicare plans annually
During open enrollment, take time to research and compare plans to find the best Medicare coverage for your healthcare needs. Find out which ones cover Entresto and what your out-of-pocket costs may look like. As a reminder, Medicare Part D and Medicare Advantage plans (Part C) typically cover Entresto. “I encourage comparing Medicare plans annually since drug tiers differ widely,” Dr. Lyons says. “Track deductible and coverage-gap phases to anticipate changes in copay.”
Medicare Extra Help
If you’re enrolled in Medicare Part D and have limited income and assets, you might be eligible for the Extra Help program. This federally-administered program helps beneficiaries pay for copays, coinsurance, premiums, and deductibles.
You may already be enrolled in the Extra Help program if:
- You have full Medicaid coverage; or
- You receive assistance from your state to pay for your Part B premiums; or
- You receive Supplemental Security Income (SSI) payments from Social Security.
If you’re not automatically enrolled in the Extra Help program, you can apply for the financial assistance online. If accepted, you will likely pay a lower copay or coinsurance for Entresto.
Explore patient assistance programs
The Novartis Patient Support program helps patients start, stay on, and save money on Novartis medications, including Entresto. By calling the support contact for Entresto (1-888-368-7378), you can speak with a representative to explore your options for lowering your Entresto prescription costs.
Use a SingleCare coupon
Another way to lower your Entresto copay is to use a SingleCare coupon. You can visit Entresto’s coupon page to get a 30-day supply of generic Entresto for $48 at CVS Pharmacy.
While manufacturer patient assistance programs and copay discounts often exclude Medicare enrollees from participating, you can use the SingleCare coupon if you have a Part D or Medicare Advantage drug plan. In fact, your cost for Entresto may be lower than your Medicare copay.
Please note that you cannot use a discount card in conjunction with your Medicare drug coverage. Additionally, any money spent out of pocket when using a discount card at your pharmacy will not count toward your Medicare Part D deductible or annual out-of-pocket maximum.
Save up to 80% on Entresto with SingleCare
Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
To get the SingleCare Entresto coupon for Medicare patients, visit the drug’s coupon page, choose your preferred pharmacy, and print or download the coupon to your mobile device. You’ll take this coupon to your pharmacy to get your Entresto discount.
Use a mail-order pharmacy
Buying Entresto in bulk from a mail-order pharmacy may help lower your costs of Entresto while on Medicare. “Mail order generally will allow patients to pay less for their medications,” Dr. Oen-Hsiao explains. “Generally, patients will pay two months’ worth of copays for three months’ worth of medications.
Look into state-specific programs
Many states have State Pharmaceutical Assistance Programs (SPAPs), which are state-run programs that help residents—often low-income older adults and individuals with disabilities—afford prescription medications. Some SPAPs offer wraparound prescription drug coverage for Medicare Part D, helping to cover the cost of medications that the plan may not cover. You can see if you meet the eligibility requirements for SPAPs by first checking if your state offers this program, and then submitting an application online, by mail, or in person, depending on your state’s process.
The SingleCare prices in this article are accurate as of January 14, 2026, for the ZIP code 23666 at the time of publication. Prices vary by pharmacy. Visit our Entresto coupon page for updated Entresto prices near you.
- Entresto (sacubitril/valsartan): First-in-class angiotensin receptor neprilysin inhibitor FDA approved for patients with heart failure, American Health & Drug Benefits (2015)
- Medicare drug price negotiation program: Negotiated prices for initial price applicability year 2026, Centers for Medicare & Medicaid Services (2024)
- Help with drug costs, Medicare.gov (n.d.)
- Extra help with Medicare prescription drug plan costs, Social Security Administration (n.d.)
- Novartis Patient Support, Novartis (n.d.)
- State Pharmaceutical Assistance Programs, National Conference of State Legislatures (2022)
- Joyce Oen-Hsiao, MD, FACC, of Yale School of Medicine
- James Lyons, MD of Synergy Houses