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Doxycycline Monohydrate vs Hyclate: Main Differences and Similarities

Doxycycline monohydrate and doxycycline hyclate both belong to the group of antibiotics called tetracyclines. They work by blocking protein synthesis which prevents the growth of bacteria. Therefore, these antibiotics are considered bacteriostatic. The only difference between doxycycline monohydrate and doxycycline hyclate is in their salt form. We’ll discuss their similarities and differences here.

Doxycycline Monohydrate

Doxycycline monohydrate (Monodox) is an antibiotic that belongs to the tetracycline group. It is used in the treatment of respiratory tract infection including pneumonia and chronic bronchitis, pelvic inflammatory disease, urinary tract infection, chlamydia, syphilis, mycoplasma, traveller’s diarrhea, cholera, malaria, plague, melioidosis, brucellosis, Q fever and other infections.

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Doxycycline monohydrate (What is Doxycycline Monohydrate?) is the less soluble salt form of doxycycline. Therefore, it may have less gastrointestinal side effects associated with it.

Doxycycline monohydrate can be purchased as a brand or generic drug. It is available as an oral capsule in varying strengths. Doxycycline monohydrate use is contraindicated in pregnancy, children, systemic lupus erythematosus (SLE), and porphyria.

Doxycycline Hyclate

Doxycycline hyclate (Doryx, Vibramycin) is an antibiotic that also belongs to the tetracyclines. It is used in treating a wide variety of infections including respiratory tract infection including pneumonia and chronic bronchitis, pelvic inflammatory disease, urinary tract infection, syphilis, chlamydia, mycoplasma, cholera, malaria, and other diseases.

Doxycycline hyclate (What is Doxycycline Hyclate?) is considered the more soluble salt form of doxycycline. It has also been the least expensive of the two salt forms.

Doxycycline hyclate can be purchased as a brand or generic drug and is usually taken as an oral capsule. Its use is contraindicated in pregnancy, children, porphyria, and systemic lupus erythematosus (SLE).

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Doxycycline Monohydrate vs Doxycycline Hyclate

Doxycycline monohydrate and doxycycline hyclate are similar drugs that differ only in their salt form. Their features can be found in the comparison table below.

Doxycycline monohydrate Doxycycline hyclate
Prescribed For
  • Respiratory tract infection including pneumonia and chronic bronchitis.
  • Urinary tract infections
  • Syphilis
  • Chlamydia
  • Pelvic inflammatory disease
  • Brucellosis
  • Plague
  • Q fever
  • Malaria
  • Traveller’s diarrhea
  • Cholera
  • Rickettsia
  • Respiratory tract infection including pneumonia and chronic bronchitis.
  • Urinary tract infections
  • Syphilis
  • Chlamydia
  • Pelvic inflammatory disease
  • Brucellosis
  • Plague
  • Q fever
  • Malaria
  • Traveller’s diarrhea
  • Cholera
  • Rickettsia
Drug Classification
  • Tetracycline
  • Tetracycline
Manufacturer
  • Generic
  • Generic
Common Side Effects
  • Headache
  • Rash
  • Diarrhea
  • Nausea
  • Vomiting
  • Sore gums
  • Muscle pain
  • Photosensitivity
  • Visual disturbance
  • Headache
  • Rash
  • Diarrhea
  • Nausea
  • Vomiting
  • Sore gums
  • Muscle pain
  • Photosensitivity
  • Visual disturbance
Is there a generic?
Is it covered by insurance?
  • Varies according to your provider
  • Varies according to your provider
Dosage Forms
  • Oral capsule
  • Oral capsule, delayed release
  • Oral tablet
  • Oral capsule
  • Oral capsule, extended release
  • Oral powder for suspension
  • Oral tablet
Average Cash Price
  • $75 for 60, 50 mg Mondoxyne NL oral capsule
  • $1,341 for 60, 100 mg Morgidox oral capsules
SingleCare Discount Price
Drug Interactions
  • Amoxicillin
  • Ampicillin
  • Lomitapide
  • Tretinoin
  • Acitretin
  • Aluminium hydroxide
  • Calcium acetate
  • Calcium chloride
  • Calcium gluconate
  • Calcium citrate
  • Fentanyl
  • Ferrous fumarate
  • Ferrous gluconate
  • Ferrous sulphate
  • Magnesium oxide
  • Magnesium sulfate
  • Magnesium citrate
  • Pancuronium
  • Rapacuronium
  • Sodium bicarbonate
  • Sodium citrate
  • Warfarin
  • Amoxicillin
  • Ampicillin
  • Lomitapide
  • Tretinoin
  • Acitretin
  • Aluminium hydroxide
  • Calcium acetate
  • Calcium chloride
  • Calcium gluconate
  • Calcium citrate
  • Fentanyl
  • Ferrous fumarate
  • Ferrous gluconate
  • Ferrous sulphate
  • Magnesium oxide
  • Magnesium sulfate
  • Magnesium citrate
  • Pancuronium
  • Rapacuronium
  • Sodium bicarbonate
  • Sodium citrate
  • Warfarin
Can I use while planning pregnancy, pregnant, or breastfeeding?
  • Doxycycline monohydrate is in pregnancy category D. it should not be taken during pregnancy. Consult a doctor regarding steps to take while planning pregnancy or breastfeeding.
  • Doxycycline hyclate is in pregnancy category D. it should not be taken during pregnancy. Consult a doctor regarding steps to take while planning pregnancy or breastfeeding.

Summary

Doxycycline monohydrate and doxycycline hyclate are antibiotics used in the treatment of a wide range of infections. Both forms of doxycycline are effective against a broad range of gram-negative and gram-positive bacteria. They work by preventing the growth of bacteria and blocking bacterial protein synthesis.

Doxycycline monohydrate and doxycycline hyclate differ only in their salt form- monohydrate and hyclate. Hyclate has greater solubility than monohydrate. However, the monohydrate form may be more tolerable. Regardless of their solubility differences, both forms are effective at treating infections.

Both forms of doxycycline should not bused in pregnant and breastfeeding women. It is also not advised to give doxycycline to children under 8 years of old.

Doxycycline monohydrate and doxycycline hyclate have significant interactions with other drugs and should not be administered with them.

The information provided here is meant for educational purpose and should be evaluated by your doctor to find the best treatment for you.