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Key takeaways
Enbrel is a brand-name drug used to treat various inflammatory autoimmune conditions, such as rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.
Enbrel can be expensive, but if you have commercial health insurance, you may be able to get it for free with the Enbrel copay card or through the manufacturer’s patient assistance program.
SingleCare Enbrel coupons can lower the cost of your prescription by about $2,000 per month.
Enbrel (etanercept) is an injectable prescription drug for people with rheumatoid arthritis and certain other autoimmune diseases, including psoriatic arthritis, plaque psoriasis, ankylosing spondylitis, and juvenile idiopathic arthritis. It is in a class of biologic drugs called tumor necrosis factor (TNF) inhibitors, which modulate the immune system to prevent inflammation. As a brand-name medication with no generic alternative, Enbrel injections are expensive without insurance or coupons. Thankfully, the Enbrel copay card, Enbrel patient assistance program, and SingleCare coupons can help you save.
How much does Enbrel cost?
Without insurance or financial assistance, Enbrel costs an average of $9,695 for four, 1 mL of 50 mg/mL syringes. Prices may vary depending on the pharmacy and the Enbrel dosage prescribed. Enbrel SureClick is more expensive, costing about $10,280 for four, 1 mL of 50 mg/mL pens.
Enbrel is often covered by commercial and government insurance, but coverage varies, prior authorization is usually required, and out-of-pocket costs vary by plan.
Do Medicare and Medicaid cover Enbrel?
According to the manufacturer, 99% of people with Medicare Part D or Medicare Advantage have Enbrel injection coverage. The out-of-pocket cost will vary by plan, but it will be considerably discounted under the Medicare Drug Price Negotiation Program. As of Jan. 1, 2026, Enbrel is now a steeply discounted Maximum Fair Price drug for Medicare prescription drug plans.
Medicaid coverage varies by state. Contact your state Medicaid agency for details, as each state has its own preferred drug list. If Enbrel is covered, the out-of-pocket cost for the drug will be minimal.
RELATED: Does Medicare cover Enbrel?
3 ways to save on Enbrel
If you don’t have insurance coverage for Enbrel, or if your copay or coinsurance is too high with insurance, there are ways to save.
SingleCare coupons for Enbrel
SingleCare negotiates low prices with pharmacies to help people afford the medications they need. Although the average retail price of Enbrel is $9,695 for four, 1 mL syringes, a SingleCare Enbrel coupon can shave about $2,000 or more off the retail price of Enbrel or Enbrel SureClick, depending on the pharmacy. Registered members save even more, and it’s fast and free to join.
Save up to 80% on Enbrel with SingleCare Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
Enbrel copay card
The Enbrel copay card is available through the drug’s manufacturer, Amgen Inc. Although the card provides significant cost savings, it is only available to those with a commercial health insurance plan that covers Enbrel. Patients who use federal or state healthcare programs, including Medicare and Medicaid, are ineligible for the Enbrel copay card.
With the Enbrel copay card, eligible patients can get Enbrel for as low as $0 per month, regardless of their financial needs. However, not everyone will get Enbrel for free with this copay card. The type of insurance coverage you have determines the copay amount you pay. Other fees may apply, like deductibles or coinsurance.
To get the Enbrel copay card, you’ll first need to enroll in Amgen SupportPlus, a personalized patient support program for patients who use Enbrel or other Amgen medications. Visit the Enbrel website for more information about eligibility criteria and the application process.
Enbrel patient assistance program
Enbrel patient assistance is available through the Amgen Safety Net Foundation, which provides free Enbrel to eligible patients who meet its eligibility requirements. While the Enbrel copay card is available to patients with commercial health insurance, the Enbrel patient assistance program is for self-paying patients without health insurance or whose insurance doesn’t make Enbrel affordable. Visit the website or talk to your healthcare provider for more information about eligibility requirements and the enrollment process.
Is there a cheaper alternative to Enbrel?
People with autoimmune diseases not only suffer the symptoms of their diagnosis but often require multiple trials of prescription drugs until settling on the treatment that best manages their symptoms. Enbrel is often used after the failure of one or more first-line, conventional disease-modifying antirheumatic drugs (DMARDs), like methotrexate.
If Enbrel does not work, less expensive Enbrel alternatives are available, including DMARDs that have not yet been tried, or other immune modulators similar to Enbrel, such as Remicade (infliximab). Your healthcare provider can recommend an alternative that’s best for your individual needs and budget.
RELATED: Enbrel vs. Humira
Bottom line
Enbrel (etanercept) is a brand-name prescription medication prescribed to treat plaque psoriasis, rheumatoid arthritis, juvenile idiopathic arthritis, and various other inflammatory autoimmune diseases. It is a TNF blocker injected under the skin of the thigh, abdomen, or outer upper arm. There is no generic Enbrel, but there are ways to reduce the cost of this brand-name drug.
The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of March 20, 2026. Prices vary by pharmacy. Visit our Enbrel coupon page for updated Enbrel prices near you.
- Enbrel HCP, Amgen Inc.
- Enbrel, DailyMed (2026)
- New lower drug prices under the Medicare Drug Price Negotiation Program, The Centers for Medicare & Medicaid Services (CMS)