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Key takeaways
Eucrisa is sometimes covered by commercial health insurance plans, but not usually by Medicare or Medicaid.
A 60 gm tube of Eucrisa costs more than $1,000 without insurance.
If you don’t have insurance, using a SingleCare savings card can save you $355 on Eucrisa. Comparing prices across pharmacies can reduce the cost, too.
More affordable Eucrisa alternatives include topical corticosteroids and other treatments.
Eucrisa is an FDA-approved nonsteroidal prescription drug. It is used to treat atopic dermatitis (eczema) in babies, children, and adults. Applied as an ointment to the affected skin twice daily, Eucrisa helps to clear up eczema symptoms, including redness, skin hardness, bumps, crusting, and oozing. Crisaborole, the active ingredient, is a PDE-4 (phosphodiesterase-4) inhibitor, but healthcare professionals are unsure why it clears up eczema. Eucrisa is a premium-priced brand-name drug. Lower-priced generic crisaborole is not yet available, and there is no over-the-counter or supplement alternative. Although Eucrisa is currently the only way to purchase topical crisaborole, there are ways to save money.
What is the generic for Eucrisa?
The active ingredient in Eucrisa isn’t sold in a generic or over-the-counter version. The soonest date a generic may come on the market is between 2027 and 2030, but this is not certain.
Is Eucrisa covered by insurance?
Eucrisa is covered by some health insurance plans, but some health plans do not cover a Eucrisa prescription. Eucrisa is usually not covered by Medicare or Medicaid plans. Insurance plans that do cover Eucrisa typically assign the drug to a second or third drug tier, so the copay may be higher than other prescription drugs.
How much does Eucrisa cost without insurance?
Without health insurance, people can expect to pay about more than $1,000 for a 60-gram tube of 2% Eucrisa ointment. How long a single tube will last depends on several variables: the amount of skin affected, the amount of ointment that a person applies to the affected areas, and how faithful the twice-daily dosing schedule is kept. It also depends on how many days the prescribing healthcare provider wants the medicine applied to the skin. Eucrisa should only be applied as a thin layer to the skin. Excess use could deplete the prescribed supply. This is why long-term cost is equally hard to calculate. Eucrisa is not intended as a maintenance treatment, so that most people will use it only during an eczema outbreak. If Eucrisa is used constantly throughout the year, it may be a good idea to ask the prescriber for medical advice about lower-priced treatment options. If a lower-priced drug or alternative is needed due to an allergic reaction, the standard alternative would be a corticosteroid for topical use, like hydrocortisone cream or ointment.
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
|---|---|---|---|
| Eucrisa | $1,064 per 1, 60 gm of 2% ointment | $709 per 60 gm of 2% ointment of brand-name Eucrisa at Harris Teeter | See latest prices |
| Tacrolimus | $310 per 1, 30 gm of 0.1% ointment | $35 per 1 30 gm of 0.1% ointment of generic tacrolimus at CVS | See latest prices |
| Pimecrolimus | $411 per 1, 30 gm of 1% ointment | $42 per 1, 30 gm of 1% ointment of generic pimecrolimus at Publix | See latest prices |
| Hydrocortisone | $24 per 1, 30 gm of 2.5% cream | $4 per 30 gm of 2.5% cream of generic hydrocortisone at Walmart | See latest prices |
| Dupixent | $5,362 per 2, 2 mL of 300 mg/2 mL solution prefilled syringes | $3,784 per 2, 2 mL of 300 mg/2 mL solution prefilled syringes of brand-name Dupixent at Walgreens | See latest prices |
Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in zip code 23666 as of Oct. 9, 2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the link under “Savings options” to see the latest drug prices.
How to get Eucrisa without insurance
Brand-name drugs like Eucrisa can be challenging to purchase without insurance. In fact, many people with insurance may need to pay the full retail price for Eucrisa because the health plan may not cover it. However, more dependable ways to save money on Eucrisa are available, starting with a SingleCare prescription discount card.
1. Save up to $355 with a SingleCare savings card
With a free coupon from SingleCare, Eucrisa can cost $709 for a 60-gram tube of 2% crisaborole. This represents a savings of $355 off the average retail price of $1,064. SingleCare Eucrisa discounts will vary by participating pharmacies. Check current prices and discounts on SingleCare’s Eucrisa coupons page.
2. Shop for the lowest price
Like all retailers, pharmacies charge different prices for the same prescriptions. For example, in Hampton, VA, Eucrisa costs $817 at Food Lion with SingleCare but $709 at Harris Teeter with SingleCare. Comparing pharmacy prices for Eucrisa could save you an additional $100.
3. Ask the prescriber about other treatment options
Many people who are prescribed Eucrisa have probably used topical corticosteroids to control eczema without much success. Still, topical steroids are the most affordable treatment for eczema. Other topical treatments and oral drugs may also be more affordable, so ask the prescriber for medical advice about these other treatment options.
4. Research health insurance or Medicaid
Health insurance may be a good way to save money if annual medical costs are substantial. However, not every health insurance plan covers Eucrisa. The first place to start is the state’s health insurance marketplace. Make sure to check the plan’s formulary to make sure Eucrisa is covered without restrictions.
5. Research Medicaid or CHIP
Medicaid and CHIP are government-subsidized health insurance plans that could reduce the cost of healthcare and prescription drugs to a minimal amount. However, Eucrisa may not be covered by some plans. Start with the state’s Medicaid website to research eligibility criteria, enrollment instructions, and additional information. Then make sure to see if the plans will cover an Eucrisa prescription.
The SingleCare prices in this article are the most accurate at the time of publishing in zip code 23666 as of Oct. 9, 2025. Prices vary by pharmacy. Visit our Eucrisa coupon page for updated Eucrisa prices near you.