Drug vs. Drug

Latuda vs Abilify: Main Differences and Similarities

SingleCare Logo for author page By | January 24, 2019

Latuda (lurasidone) and Abilify (aripiprazole) are brand name medications used to treat schizophrenia and other psychiatric disorders. Both medications are classified as atypical antipsychotics. They work by regulating activity at dopamine and serotonin receptors in the brain. While both medications are similar in many ways, they also have some differences in how they are used.

Latuda

Latuda is the brand name for lurasidone hydrochloride. It was approved in 2010 to treat schizophrenia in adults and adolescents aged 13 to 17 years old. It can also treat depressive episodes from bipolar I disorder in adults and children aged 10 to 17 years old. For bipolar depression, it can be used alone or with other medication.

Latuda is available as a 20 mg, 40 mg, 60 mg, 80 mg, and 120 mg oral tablet. It is absorbed with maximum concentrations in the blood reached within 1 to 3 hours. Latuda is usually started at a dose of 20 or 40 mg depending on the condition being treated.

Abilify

Abilify is the brand name for aripiprazole. It is an atypical antipsychotic approved in 2002 to treat schizophrenia in adults and adolescents aged 13 to 17 years old. Other uses include treatment for major depressive disorder, irritability associated with autistic disorder, and tourette’s syndrome. It can also treat manic and mixed-manic and depressive episodes associated with bipolar I disorder.

Abilify is administered as an oral tablet that comes in strengths of 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, and 30 mg. Orally disintegrating tablets and oral solutions are also available. An injection can also be given to treat schizophrenia or bipolar mania. Peak concentrations can be reached within 3 to 5 hours after administration of oral tablets. After injection, peak concentrations can be reached within 1 to 3 hours.

Latuda vs Abilify Side by Side Comparison

Latuda and Abilify are two commonly prescribed antipsychotics. Although they share some similarities in use, they also have differences that are further outlined below.

Latuda Abilify
Prescribed For
  • Schizophrenia
  • Bipolar disorder (depressive episodes)
  • Schizophrenia
  • Bipolar disorder (manic and mixed episodes)
  • Tourette’s syndrome
  • Major Depressive Disorder (MDD)
  • Autistic disorder
Drug Classification
  • Antipsychotic
  • Antipsychotic
Manufacturer
Common Side Effects
  • Weight gain
  • Somnolence
  • Diarrhea
  • Nausea
  • Vomiting
  • Akathisia
  • Extrapyramidal symptoms
  • Tremors
  • Anxiety
  • Insomnia
  • Rhinitis
  • Weight gain
  • Somnolence
  • Restlessness
  • Insomnia
  • Constipation
  • Fatigue
  • Headache
  • Blurred vision
  • Akathisia
  • Extrapyramidal symptoms
  • Tremor
  • Anxiety
  • Nausea
  • Vomiting
  • Sedation
Is there a generic?
  • No generic currently available
Is it covered by insurance?
  • Varies according to your provider
  • Varies according to your provider
Dosage Forms
  • Oral tablet
  • Oral tablet
  • Oral tablet, disintegrating
  • Oral solution
  • Injection
Average Cash Price
  • $1,389 (per 30 tablets)
  • $855 (per 30 tablets)
SingleCare Discount Price
Drug Interactions
  • CYP3A4 inhibitors (erythromycin, clarithromycin, fluconazole, ketoconazole, ritonavir, diltiazem, verapamil, etc.)
  • CYP3A4 inducers (rifampin, phenytoin, carbamazepine, St. John’s wort, bosentan, etravirine, modafinil, efavirenz, etc.)
  • CYP3A4 inhibitors (erythromycin, clarithromycin, fluconazole, ketoconazole, ritonavir, diltiazem, verapamil, etc.)
  • CYP3A4 inducers (rifampin, phenytoin, carbamazepine, St. John’s wort, bosentan, etravirine, modafinil, efavirenz, etc.)
  • CYP2D6 inhibitors (quinidine, paroxetine, fluoxetine, etc.)
  • Antihypertensives
  • Benzodiazepines
Can I use while planning pregnancy, pregnant, or breastfeeding?
  • Latuda is in Pregnancy Category B. Not enough clinical data is available on fetal risks. Consult a doctor regarding steps to take if planning pregnancy or breastfeeding.
  • Abilify is Pregnancy Category C. Animal studies have shown adverse effects to the fetus. Adequate studies have not been performed in humans. Consult a doctor regarding steps to take while pregnant and breastfeeding.

Summary

Latuda and Abilify are atypical antipsychotic medications that can treat schizophrenia among other conditions. They can also treat bipolar disorder. However, Latuda primarily treats depressive episodes and Abilify treats manic or mixed episodes. Abilify also has additional uses for Tourette’s syndrome, autistic disorder, and major depressive disorder.

Both antipsychotics are effective medications with similar side effects. They both may cause weight gain, somnolence, and fatigue. However, Latuda is marketed as having less of an effect on weight gain compared to Abilify.

Both medications have similar onsets of action with effects produced within hours. Abilify has additional formulations such as orally disintegrating tablets, solutions, and injections for faster absorption. Abilify may be preferred for certain patients with acute symptoms from a broader range of conditions.

Latuda or Abilify should only be used with a prescription from your doctor. Because they each have different uses, your overall condition should be reviewed before choosing one medication.