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Key takeaways
Rexulti is an effective but costly medication used to treat depression, schizophrenia, and Alzheimer’s-related agitation. Uninsured patients may potentially pay over $2,000 per month. Most insured patients receive coverage, though costs vary by plan.
There are several ways to save on Rexulti, including manufacturer savings cards, SingleCare coupons, patient assistance programs, 90-day prescriptions, and nonprofit or state-level aid for eligible individuals.
Cheaper alternatives to Rexulti may include generics or similar drugs like aripiprazole, quetiapine, or SSRIs/SNRIs, which may be better covered by insurance or available at significantly lower prices. However, a healthcare provider should guide any medication changes.
Major depressive disorder (MDD) and other mental health conditions can take the color out of life, making it difficult to function from day to day. That’s in part why around 1 in 10 Americans take antidepressants, and why atypical antipsychotic medications like Rexulti (brexpiprazole) are increasingly popular. Not only is Rexulti an adjunctive treatment for depression, but it’s also approved to treat schizophrenia and agitation associated with Alzheimer’s disease or dementia.
Without insurance coverage or other financial assistance, Rexulti can be fairly pricey, which might leave uninsured or underinsured patients looking for help. The good news is that there are several ways to save.
Save up to 80% on Rexulti with SingleCare
Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
How much does Rexulti cost?
If you waltz into a pharmacy to pick up your Rexulti prescription—no insurance coverage, coupons, discounts, or other savings—you could pay around $2,025 for 30, 1 mg tablets. That’s a 30-day supply, so over an entire year, you would end up paying around $24,000.
Yet most people who have health insurance won’t be in that situation. According to data from Rexulti’s website, 95% of patients with insurance will receive coverage, including Medicare Part D plans. That coverage could reduce the out-of-pocket cost significantly. In fact, per the drug’s website, here are the average monthly costs for patients with different insurance types:
- Commercial insurance: $31.15
- Medicare Part D: $21.37
- Medicaid: $2.88
- VA benefits or TRICARE: $59.88
These are just averages, and the actual costs and copays can vary significantly depending on your particular plan. “Some insurance companies require prior authorization, and others may ask you to try different medications before covering Rexulti,” says Dr. Randall Turner, Board-Certified Psychiatrist, D.O. & Medical Director at Able To Change Recovery. “That said, I always remind patients that even if their plan does cover it, the copay can still be steep.”
Can I get Rexulti for free?
Getting prescription drugs for free might seem far-fetched, but it’s possible in certain situations. For example, Otsuka America Pharmaceutical (Rexulti’s manufacturer) offers a Rexulti savings card that they say can bring out-of-pocket costs as low as $0 per refill.
“Most commercially insured patients can get their first two fills free and then continue with a low copay,” Dr. Turner says. “It is one of the better copay assistance programs available, and the process is relatively straightforward for both patients and pharmacies.”
However, there are some stipulations. Eligible patients must have commercial insurance that covers some but not all of the cost. They cannot receive assistance from government-sponsored programs like Medicare, Medicaid, Medigap, Department of Defense programs, TRICARE, or VA benefits. However, even individuals who meet those requirements might not get Rexulti for free. It depends on their specific healthcare plan, pharmacy, and location. Also, the card has an annual maximum savings of $8,180.
Some healthcare providers might also receive free samples from the manufacturer, which they can distribute to patients. However, these typically only cover a couple of doses, so it’s not a reliable way to get Rexulti for free long-term.
How to save money on Rexulti
Insurance is the most common way to lower the cost of Rexulti, and the Rexulti savings card is another popular option, but other methods can yield significant savings. Here are a few of the most reliable ones.
1. Free Rexulti coupon card
At the grocery store, coupons can save a few bucks. SingleCare coupons can save hundreds on Rexulti (and other prescription medicines) at the pharmacy. They can knock up to around $600 off the $2,000+ average retail price. All you have to do is sign up for free, then present the SingleCare discount card at a local partner pharmacy. You can use SingleCare discounts even if you have insurance or Medicare coverage, but you can’t use both at the same time, so you’ll have to see which one provides a bigger discount.
2. Otsuka Patient Assistance Foundation
Otsuka’s Rexulti savings card is great, but it only benefits people with certain types of insurance—not people who are uninsured. This patient assistance program helps fill in those gaps. To qualify, patients must have a U.S. home address, be uninsured or underinsured, and meet certain income requirements. They don’t list the specific income thresholds on their website, but you can submit your insurance and income information, and they’ll tell you if you’re eligible.
3. Generic alternatives
The FDA estimates that generic drugs can be as much as 80–85% cheaper than their brand-name references. The FDA approved generic brexpiprazole in 2025, and while it takes time before new drugs become commercially available, it could be much more affordable. Some Rexulti alternatives have generic options too. Abilify’s generic (aripiprazole), for example, can cost as little as $16 with a SingleCare coupon, while generic Risperdal (risperidone) might cost just $9 with a coupon.
Be sure to consult a healthcare provider to determine whether a different drug might be viable and, if so, which one they recommend.
4. 90-day prescriptions
Typically, 30-day prescriptions are the norm. However, an increasing number of doctors and pharmacies are prescribing and filling 90-day supplies. One study found that patients who used 90-day prescriptions had a 29% decrease in out-of-pocket costs and an 18% decrease in total prescription costs compared to those who got 30-day prescriptions. Plus, you won’t need to go to the pharmacy nearly as often.
5. Health insurance plans
If your insurance plan won’t cover Rexulti, look into switching plans during the next Open Enrollment Period. Whether you have an employer-sponsored plan or individual health insurance, look over the formularies for other plans to see which ones might provide coverage. They might have higher premiums or deductibles, but it might even out with the money you save on your prescriptions.
For people without insurance, the Healthcare Marketplace is a great resource for browsing plans that might work with their budget and provide the coverage they need.
6. Government-funded assistance
Some individuals might also be eligible for Medicaid, a program jointly funded by the state and federal governments that provides financial assistance for people who need help paying medical expenses. You don’t need insurance or Medicare to qualify for Medicaid, but you do need to meet particular income requirements, which vary by state.
Many states also have their own assistance programs for prescriptions and/or other medical costs. For example, New York has Uninsured Care Programs that provide access to free healthcare for uninsured or underinsured residents. You can find a list of these state-level programs on the National Council of State Legislatures website.
7. Nonprofit assistance programs
Some nonprofit and charitable organizations also provide financial assistance for prescription drugs. The Patient Advocate Foundation, for example, has a Copay Relief program you can apply for on their website. Needymeds.com is a good place to start looking for opportunities like this—you can search their database for programs that might be a good fit.
Is there a cheaper alternative to Rexulti?
As we mentioned above, some similar drugs might be more affordable than Rexulti. Or, in some cases, your insurance plan might offer better coverage for them. “We look at alternatives like aripiprazole or quetiapine, which are in the same general category of atypical antipsychotics,” Dr. Turner says. “They can be more affordable and may work well for some patients, depending on the condition being treated and how the patient has responded to medications in the past.”
Since drug prices can vary based on insurance plan, pharmacy, and even location, Rexulti alternatives won’t always be cheaper, but they’re worth considering.
- Other atypical antipsychotics: Drugs like Abilify, Clozaril, and Latuda treat some of the same conditions as Rexulti—and some of them even have generic options.
- Typical antipsychotics: Atypical (aka second-generation) antipsychotics like Rexulti have fewer movement-related side effects than typical antipsychotics like Haldol (haloperidol) or Loxitane (loxapine). However, these might be an option for some people.
- Selective Serotonin Reuptake Inhibitors (SSRIs): For people taking Rexulti for depression, these antidepressants, like Prozac or Zoloft, might be good alternatives. However, Rexulti is often prescribed in combination with one of these drugs.
- Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Like SSRIs, these are solid options for people who have depression, although healthcare providers may prescribe them alongside Rexulti rather than as a replacement.
It’s important to always consult a healthcare provider if you’re thinking about switching drugs. Since they know your medical condition best, they can recommend the best drug for your health and financial circumstances.
- Characteristics of Adults Age 18 and older who took prescription medication for depression: United States, 2023, CDC (2023)
- Rexulti savings & cost, Rexulti website
- Otsuka patient assistance foundation, Otsuka website
- Generic drugs: questions & answers, FDA (2021)
- Cost savings associated with filling a 3-month supply of prescription medicines, Applied Health Economics and Health Policy (2009)
- State pharmaceutical assistance programs, National Council of State Legislatures (2022)