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How much is Trelegy Ellipta without insurance?

There are ways to make Trelegy more affordable if you don't have insurance
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By | Updated on Oct. 21, 2025 Medically reviewed by Marissa Walsh, Pharm.D., BCPS-AQ ID & Karen Berger, Pharm.D.

Key takeaways

  • Trelegy Ellipta (fluticasone/umeclidinium/vilanterol) is a brand-name inhaler used for maintenance treatment of COPD and asthma. It is not a rescue inhaler.

  • The Trelegy Ellipta cost without insurance is about $914 per month. With a Trelegy Ellipta coupon from SingleCare, you could pay as low as $534 per month. 

  • Many insurance plans provide coverage for Trelegy Ellipta. You can check with your specific plan for more information on coverage and costs.

In this article:

Trelegy Ellipta (fluticasone/umeclidinium/vilanterol) is a brand-name prescription inhaler containing three types of medications to prevent breathing problems and flare-ups in people with chronic obstructive pulmonary disease (COPD, which includes chronic bronchitis and emphysema) or asthma. Inhaled once daily as a maintenance treatment, Trelegy Ellipta is not intended as a rescue inhaler for acute bronchospasms. Trelegy Ellipta is an expensive brand-name drug with no less-expensive generic version. That means paying the full retail price can be difficult for uninsured people, but a few suggestions may help make it more affordable.

How much does Trelegy Ellipta cost without insurance?

If you are paying out of pocket, you should expect to pay an average of $914 per month for Trelegy Ellipta. This will purchase a single plastic inhaler with two foil strips that each have 30 blisters of inhalation powder. Each inhaled dose uses two blisters, one from each foil strip, so the inhaler represents a 30-day supply. When used as a long-term maintenance treatment, Trelegy Ellipta will cost more than $10,000 a year for uninsured patients.

Drug namePrice without insurance of brand-name drugSingleCare priceSavings options
Trelegy Ellipta 

(fluticasone-umeclidinium-vilanterol)

$914 per 60 blisters of 100 mcg/62.5 mcg/25 mcg aerosol powder$534 per 60 blisters of 100 mcg/62.5 mcg/25 mcg aerosol powder of brand-name Trelegy Ellipta at KrogerSee updated prices
Breztri Aerosphere (budesonide-glycopyrrolate-formoterol)$919 per 10.7 gm inhaler of 160 mcg/9 mcg/4.8 mcg aerosol powder$553 per 10.7 gm inhaler of 160 mcg/9 mcg/4.8 mcg aerosol powder of brand-name Breztri Aerosphere at KrogerSee updated prices 

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of 10/21/2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.

Is Trelegy Ellipta covered by insurance?

Some insurance plans, including commercial health insurance, Medicare Part D, and Medicaid plans, cover Trelegy Ellipta, but not all. Even if a plan does cover Trelegy, out-of-pocket costs vary and depend on the plan’s formulary, copay, and coinsurance. When insurance plans do cover Trelegy Ellipta, they typically classify the brand as a higher-tier drug. According to GSK, the manufacturer of Trelegy, about 82% of paid Trelegy prescriptions cost less than $50 per month with either commercial health insurance, such as through an employer, or with a Medicare prescription plan. Additionally, many Medicaid plans provide coverage for Trelegy, but Medicaid coverage varies by state. The best way to verify coverage is to look up your drug formulary online or contact your health insurance provider.

COPD Coupons & Resources

Insurance companies may require you to try cheaper alternatives to Trelegy Ellipta before approving coverage. This is called step therapy. To understand your options, it helps to know the active ingredients in Trelegy: fluticasone furoate, umeclidinium, and vilanterol, which are all delivered in a single dose. Fluticasone is an inhaled corticosteroid (ICS) that prevents swelling of the airways and is a necessary part of asthma maintenance treatment. The next two affect the muscles in the airways. Vilanterol is a long-acting beta-agonist (LABA) that makes breathing easier by relaxing and widening the muscles in the airways. Umeclidinium is an anticholinergic or long-acting muscarinic antagonist (LAMA) that prevents those muscles from contracting. Trelegy Ellipta is an ICS-LAMA-LABA inhaler. There’s only one similar triple therapy single inhaler on the market: Breztri Aerosphere. 

Another alternative is to use more than one inhaler to achieve the same goal of using three active ingredients. Typically, this is done with two inhalers, one of which contains two active ingredients.

How to get Trelegy Ellipta without insurance

$10,000 a year is a lot to pay for a drug, even for life-saving medicine like Trelegy Ellipta. Thankfully, there are ways to save on Trelegy without insurance. With a SingleCare prescription discount savings card or coupon, the lowest monthly price for Trelegy Ellipta is $534. That’s almost half the cost of the average retail price. Discounts will vary by participating pharmacies, but most will save $200 or more off the price of Trelegy. If Trelegy Ellipta is cost-prohibitive, ask your healthcare provider for additional information and medical advice on Trelegy alternatives.