Apriso is a prescription medication used to treat mild to moderate ulcerative colitis in adults 18 years and older. Apriso is also indicated for the maintenance of remission of ulcerative colitis in adults. It works by affecting substances in the body responsible for tissue damage, diarrhea, and inflammation. The average retail price tag for a one-month supply of Apriso is around $666.49 for 120, 0.375gm capsules extended release 24 hour. To avoid sticker shock, you can use one of SingleCare's coupons for Apriso to save on the total cost of Apriso and pay $43.80 for 120, 0.375gm capsules extended release 24 hour of generic Apriso.
Edit your dosage
30 capsule extended release 24 hour, 0.375gmEdit
Unlock members-only prices.Free signup.
You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.
Show this free card to your pharmacist.

Save an extra $3 on any eligible prescription! Sign up for free
Members can save even more
and it's free to join
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/20/2025
Members save the most
Apriso is a prescription medication used to treat mild to moderate ulcerative colitis in adults 18 years and older. Apriso is also indicated for the maintenance of remission of ulcerative colitis in adults. It works by affecting substances in the body responsible for tissue damage, diarrhea, and inflammation. The average retail price tag for a one-month supply of Apriso is around $666.49 for 120, 0.375gm capsules extended release 24 hour. To avoid sticker shock, you can use one of SingleCare's coupons for Apriso to save on the total cost of Apriso and pay $43.80 for 120, 0.375gm capsules extended release 24 hour of generic Apriso.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Mesalamine Er Retail Price | Mesalamine Er SingleCare Price |
|---|---|---|
| CVS Pharmacy | $477.60 | $44.40 |
| Walmart | $426.00 | $68.40 |
| Walgreens | $181.64 | $172.15 |
| Kroger Pharmacy | $550.80 | $135.60 |
| Albertsons Pharmacy | $468.00 | $110.40 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Apriso is a prescription medication used to treat mild to moderate ulcerative colitis in adults 18 years and older. Apriso is also indicated for the maintenance of remission of ulcerative colitis in adults. It works by affecting substances in the body responsible for tissue damage, diarrhea, and inflammation. The average retail price tag for a one-month supply of Apriso is around $666.49 for 120, 0.375gm capsules extended release 24 hour. To avoid sticker shock, you can use one of SingleCare's coupons for Apriso to save on the total cost of Apriso and pay $43.80 for 120, 0.375gm capsules extended release 24 hour of generic Apriso.
On average, the price of Apriso is $666.49 for 120, 0.375gm capsules extended release 24 hour without insurance and before applicable coupons. Sign up for a free SingleCare savings card, which you'll receive in the mail and via mobile app, to pay a discounted rate of $43.80 for 120, 0.375gm capsules extended release 24 hour of generic Apriso.
Apriso costs with insurance have a wide range. As with all prescription drugs, your copay depends on the type of insurance policy that you have and its specific drug formulary. You may need to check with your pharmacist to determine the actual cost of Apriso through your insurance plan.
If you find out that the cash price of Apriso is actually lower than your cost with insurance, remember to use SingleCare's discount discount card. This allows you to purchase Apriso for as low as $43.80 for 120, 0.375gm capsules extended release 24 hour of generic Apriso at certain drugstores, like CVS, Walmart, Walgreens, Duane Reade, and more.
Apriso is covered by the majority of Medicare Part D and Medicare Advantage plans with a copay range of $19-$633. Even if your medication is partially covered by Medicare or another insurance plan, always present your SingleCare card to the pharmacist for processing. Our lowest price may actually work out to be less than Medicare. Request to compare SingleCare's pricing against Medicare's drug pricing at a local pharmacy.
Apriso is a brand-name prescription medication manufactured by Salix Pharmaceuticals. Lupin Pharmaceuticals, Mylan, and Valeant Pharmaceuticals also manufacture generic versions of Apriso, called mesalamine extended-release capsules.
If you suffer from ulcerative colitis, your doctor may prescribe Apriso to maintain remission. It assists in preventing uncomfortable and dangerous symptoms of ulcerative colitis such as rectal bleeding, stomach pain, and diarrhea, from returning. Apriso belongs to a class of drugs that are known as aminosalicylates, which mainly work by reducing swelling and inflammation in the colon.
Apriso is available in 0.375 g extended-release capsules. These are taken orally and your doctor will likely prescribe the recommended dosage of four capsules per day. Apriso can be taken without meals but should not be administered with antacids. Do not chew, crush, cut, or break Apriso capsules.
Common side effects of Apriso include headaches, diarrhea, nausea, stomach pain, dizziness, ringing in the ears, and pressure in the stomach. Some side effects that occur may not require immediate medical care and will eventually go away after your body adjusts to the medication. You can also seek medical advice from your doctor about ways to avoid or reduce certain side effects. There may also be other side effects related to Apriso since this is not a complete list.
Talk to your doctor before taking Apriso if you have kidney problems.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
Health education, drug info, wellness & more
SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved