What is Caplyta? Uses, warnings & side effects

Take Caplyta as directed. Do not change the dose without talking to the prescriber. 

Please read the medication guide that comes with this medicine.

Take Caplyta only once per day.

Caplyta capsules can be taken with or without food.

Swallow the capsule whole with a glass of water.

Store Caplyta capsules at room temperature in a closed container out of the reach of children.

Ask the prescriber what to do if a dose of Caplyta is missed.

Caplyta is not right for everyone.

Do not use Caplyta if you have had an allergic reaction to the drug.

Tell any doctor or other healthcare provider who treats you that you are using this medicine.

Your doctor may need regular visits and lab tests to monitor Caplyta’s effectiveness and safety. Keep all appointments.

Tell your doctor if you are pregnant, breastfeeding, or have:

• Kidney problems

• Liver problems

• Heart problems

• A history of stroke

• High or low blood pressure

• A family history of diabetes or high blood sugar

• High cholesterol

• A history of seizures

• Low white blood cell counts

Caplyta can cause serious side effects and complications, including: 

• Neuroleptic malignant syndrome (NMS), a potentially life-threatening complication of antipsychotic medications

• Involuntary facial and other movements

• Seizures

• Elevated blood sugar levels

• High cholesterol and triglycerides

• Low blood pressure when standing up or changing position

• Increased risk of falls and injuries

• Increased risk of infections due to low white blood cell counts

• Weight gain

• Difficulty swallowing and increased risk of aspirating food or drink

Lumateperone can worsen mental or emotional problems and increase the risk of suicide in children, adolescents, and young adults. Talk with the prescriber right away if thoughts or behavior changes are concerning. 

This medicine may make you dizzy, drowsy, or fuzzy. It can cause lightheadedness and fainting when changing one’s position, such as standing up. Do not drive or do any other potentially hazardous activities until you know how this medicine affects you. Stand or sit up slowly to avoid lightheadedness, fainting, or falling.

Lumateperone can alter the body’s ability to regulate temperature, making people prone to overheating and dehydration. Be careful when you exercise or are outside in hot or humid weather, and drink plenty of fluids throughout the day.

Do not stop using this medicine suddenly. The prescriber will need to slowly decrease your dose before you stop it completely.

Keep Caplyta securely out of the reach of children.

To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements in use before starting Caplyta.

Tell other healthcare providers you are using Caplyta before they prescribe new medications.

Many drugs can either increase the risk of Caplyta side effects or make Caplyta less effective. The prescriber may need to avoid these drugs or change the Caplyta dose. Some common examples of these drugs include:

• The antipsychotic medications clozapine and haloperidol

• The anti-seizure drugs carbamazepine, phenytoin, primidone, and phenobarbital

• The antibiotics rifampin, clarithromycin, and erythromycin

• The antifungal drugs ketoconazole and itraconazole

• Amiodarone, atazanavir, clindamycin, darunavir, dexamethasone, nefazodone, nelfinavir, ritonavir, saquinavir

Avoid grapefruit juice, St. John’s wort, and curcumin supplements when taking Caplyta. These foods may make Caplyta less effective.