What is Pifeltro: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Jan 25, 2023

Pifeltro overview

BRAND NAMES:

  • Pifeltro

Generic Names:

  • Pifeltro

Uses:

  • Treats HIV infection in patients who have not received HIV-1 medicines before, or in patients to replace their current HIV-1 medicines who have met certain doctor's requirements. HIV causes AIDS. This medicine does not cure HIV or AIDS, but combinations of drugs may slow the progress of the disease.

Therapeutic Classes:

  • Antiretroviral Agent

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Pifeltro used for?

What form(s) does Pifeltro come in

  • Tablet

What are common Pifeltro doses?

  • Bottle 30 tablets

Common Pifeltro prescriptions

  • Pifeltro
    30 tablets bottle

How to take Pifeltro

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the bottle tightly closed. Keep the medicine in its original bottle.

  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even briefly, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

What to do if you miss a dose of Pifeltro

Pifeltro contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to doravirine.

Pifeltro warnings

  • Your immune system may get stronger when you start taking HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.

  • Tell your doctor if you are pregnant, or if you have kidney disease or liver disease.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

Pifeltro interactions

  • Some medicines can affect how doravirine works. Tell your doctor if you are also using efavirenz, etravirine, or nevirapine.

  • If you are also using rifabutin, take doravirine 2 times a day, about 12 hours apart.

  • Do not use this medicine together with carbamazepine, enzalutamide, mitotane, oxcarbazepine, phenobarbital, phenytoin, rifampin, rifapentine, or St John's wort.

Pifeltro side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Headache

  • Nausea

  • Tiredness or weakness

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