What is Propranolol ER? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Propranolol ER is a generic prescription medication used to treat high blood pressure and heart problems. Propranolol belongs to a family of drugs called beta blockers, drugs that slow the heartbeat, reduce the heart’s workload, and lower blood pressure. Extended-release propranolol capsules are taken once per day.

Propranolol ER overview

BRAND NAMES:

  • Inderal LA, Inderal XL, InnoPran XL

Generic Names:

  • Propranolol hydrochloride ER

Uses:

  • Treats high blood pressure, angina (chest pain), and enlarged heart (idiopathic hypertrophic subaortic stenosis). It also helps prevent migraine headaches.

Therapeutic Classes:

  • Beta blocker, antianginal, antihypertensive, antimigraine, cardiovascular agent

Forms:

  • Extended-release capsule

How it’s taken:

  • By mouth

What is Propranolol ER used for?

Propranolol ER treats high blood pressure, chest pain (angina), and a type of heart enlargement called hypertrophic subaortic stenosis. The FDA has also approved it as a preventive treatment for migraines.

What form(s) does Propranolol ER come in?

  • Extended-release capsules

    • 60 mg

    • 80 mg

    • 120 mg

    • 160 mg

What are common Propranolol ER dosages?

  • For hypertension in adults: 120–160 mg once per day 

  • For chest pain in adults: 80–320 mg daily taken once per day

  • For enlarged heart in adults: 80–160 mg once per day

  • For migraine prophylaxis in adults: 160–240 mg daily given once daily

Propranolol ER images - What does Propranolol ER look like?

  • Propranolol HCl ER
    120mg capsule

  • Propranolol HCl ER
    160mg capsule

  • Propranolol HCl ER
    60mg capsule

  • Propranolol HCl ER
    80mg capsule

  • Propranolol HCl ER
    120mg capsule extended release 24 hour

  • Propranolol HCl ER
    160mg capsule extended release 24 hour

  • Propranolol HCl ER
    60mg capsule extended release 24 hour

  • Propranolol HCl ER
    80mg capsule extended release 24 hour

How to take Propranolol ER

  • Follow all the prescriber’s directions. The dose may need to be changed several times to find what works best for you.

  • Take propranolol ER capsules at bedtime.

  • The capsules can be taken with or without food but must be taken the same way each time. 

  • Swallow the capsule whole with a glass of water. Do not open, chew, crush, or break the capsule.

  • Store propranolol capsules at room temperature, protected from light, moisture, freezing, and excessive heat.

What to do if you miss a dose of Propranolol ER

  • Ask the prescriber how to handle a missed dose.

  • Do not take extra medicine to make up for a missed dose.

Propranolol ER contraindications - Who shouldn't take Propranolol ER?

  • This medicine is not right for everyone. 

  • Do not use it if you have:

    • Known allergies to propranolol

    • Bronchial asthma

    • Heart block

    • Slow heart rate due to a problem with the heart’s natural pacemaker (sinus bradycardia)

  • Doctors never use propranolol in people in cardiogenic shock, a life-threatening emergency due to severe heart problems such as heart attack, severe heart failure, or the rupture of a heart valve.

Propranolol ER warnings

  • Tell any doctor or other healthcare provider who treats you that you are taking propranolol. Propranolol may need to be stopped before major surgery.

  • Propranolol treatment requires regular doctor visits and lab tests to monitor the treatment and side effects. Keep all appointments.

  • Tell your doctor if you are pregnant, breastfeeding, or have:

    • A history of heart failure

    • Chest pain

    • Heart rhythm problems

    • Lung or breathing problems

    • Kidney disease

    • Liver disease

    • Overactive thyroid

    • Diabetes

    • A history of severe allergic reactions

  • This medicine may cause the following problems: 

    • Worsening of angina

    • Worsening of heart failure

    • Slow heart rate

    • Breathing problems

    • Severe allergic reactions

  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Propranolol can lead to low blood sugar (hypoglycemia) in people with diabetes or who are fasting.

  • Do not stop using this medicine suddenly. The dose will need to steadily decrease before this medicine can be stopped completely.

Propranolol ER interactions & what to avoid when taking Propranolol ER

  • To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements you use, particularly:

    • Drugs that treat irregular heartbeats

    • Drugs that affect the heart

    • Blood pressure medications

    • NSAIDs such as aspirin or ibuprofen

    • Drugs that treat depression

    • MAO inhibitors (MAOIs)

    • Thyroid hormones

    • Corticosteroids such as prednisone

    • Cimetidine, dobutamine, haloperidol, isoproterenol, rizatriptan, theophylline, warfarin, zolmitriptan

  • Propranolol is contraindicated in anyone taking the antipsychotic drug thioridazine.

  • Avoid alcohol when taking propranolol.

  • Tell other healthcare providers you are using this medicine before they prescribe new medications.

Find more detailed information about propranolol interactions to avoid here.

Propranolol ER side effects - How does Propranolol ER make you feel?

Serious Side Effects

Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:

  • Slow, fast, or uneven heartbeat

  • Chest pain or worsening chest pain

  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness

  • Difficulty breathing, wheezing

  • Lightheadedness, dizziness, or fainting

  • Blistering, peeling, or red skin rash

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Fatigue

  • Dizziness

  • Lightheadedness

  • Nausea

Find more detailed information about propranolol side effects here.

Sources:

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