Rifabutin is an FDA-approved generic prescription antibiotic used to prevent mycobacterium avium complex (MAC) infection in people with HIV/AIDS. Rifabutin works as an antimycobacterial drug that kills the bacteria responsible for the MAC infection. The average cash price of Rifabutin is $1,065.7, but the cost may be lowered to $373.98 with SingleCare's Rifabutin coupon at participating pharmacies.
Edit your dosage
14 capsule, 150mgEdit
Unlock members-only prices.Free signup.
You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.
Show this free card to your pharmacist.

Save an extra $3 on any eligible prescription! Sign up for free
Members can save even more
and it's free to join
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
Members save the most
Rifabutin is an FDA-approved generic prescription antibiotic used to prevent mycobacterium avium complex (MAC) infection in people with HIV/AIDS. Rifabutin works as an antimycobacterial drug that kills the bacteria responsible for the MAC infection. The average cash price of Rifabutin is $1,065.7, but the cost may be lowered to $373.98 with SingleCare's Rifabutin coupon at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Rifabutin Retail Price | Rifabutin SingleCare Price |
|---|---|---|
| CVS Pharmacy | $915.00 | $426.00 |
| Walmart | $693.60 | $693.60 |
| Walgreens | $831.60 | $544.80 |
| Kroger Pharmacy | $1050.00 | $628.80 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Rifabutin is an FDA-approved generic prescription antibiotic used to prevent mycobacterium avium complex (MAC) infection in people with HIV/AIDS. Rifabutin works as an antimycobacterial drug that kills the bacteria responsible for the MAC infection. The average cash price of Rifabutin is $1,065.7, but the cost may be lowered to $373.98 with SingleCare's Rifabutin coupon at participating pharmacies.
Patients can usually expect to pay $1,065.7 for 60, 150mg capsules of Rifabutin. However, the actual retail price can vary depending on various factors, such as the dosage and quantity prescribed. You could pay $373.98 with a SingleCare prescription savings card. When purchasing generic and brand-name prescription drugs, you can save as much as 80% with SingleCare savings cards.
The amount of your Rifabutin copay can vary depending on your insurance plan. Check with your insurance provider to find out the exact cost of Rifabutin with insurance. With SingleCare, Rifabutin may cost $373.98, which could be lower than your insurance copay.
As a generic antibiotic, Rifabutin is usually covered by Medicare Part D and Medicare Advantage prescription drug plans. The actual copay can vary based on the dosage and quantity of Rifabutin prescribed. For patients without Medicare, a SingleCare Rifabutin coupon may be helpful to reduce the cost of the retail price.
Rifabutin is a generic prescription drug manufactured by Lupin and other manufacturers. Mycobutin is the brand-name version of Rifabutin manufactured by Pfizer. You can search for the generic and brand-name version on the SingleCare website or app for important information and savings coupons.
Rifabutin is a generic antibiotic used to prevent mycobacterium avium complex (MAC) infection in people with advanced HIV/AIDS. Some people who are infected with MAC do not exhibit any symptoms. However, this infection can be a dangerous opportunistic infection in people with HIV/AIDS due to a weakened immune system.
Rifabutin belongs to a class of antibiotics called antimycobacterials. Rifabutin works by interfering with the bacteria’s ability to create the proteins it needs to function properly. It is usually combined with other antibiotics to treat MAC infection.
Side effects of Rifabutin include rash, stomach pain, low white blood cell count, headache, nausea, vomiting, muscle aches, insomnia, unusual taste in the mouth, diarrhea, fever, and gas.
Serious side effects of Rifabutin include severe diarrhea and skin reactions. Allergic reactions are possible and may include symptoms like hives, rash, and difficulty breathing. Seek immediate medical attention if you experience an allergic reaction while taking Rifabutin.
This is not a complete list of side effects. Consult your doctor or healthcare professional for additional information and medical advice regarding other possible side effects or drug interactions. You can report negative side effects to the FDA.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
Health education, drug info, wellness & more
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved