Trezix is a prescription drug that is used for the relief of moderate to severe pain. Trezix is a brand-name drug. Acetaminophen-caffeine-dihydrocodeine is the generic version of Trezix. On average, the cost of Trezix is around $349.76. If you want to save when you buy your first prescription or you need a refill of Trezix, you can use a free Trezix coupon or pharmacy coupons from SingleCare to pay a reduced cost of $206.29.

Set your location
Get alerted when the price
changes more than 10%

20 capsule320.5-30-16mgEdit

Unlock members-only prices.Free signup.

You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.

Trezix coupon at Food Lion Pharmacy
$ 206.29

Show this free card to your pharmacist.

Coupon card loading
Trezix coupon at Kroger Pharmacy
$ 207.95
Trezix coupon at Harris Teeter Pharmacy
$ 207.95
Trezix coupon at Publix Pharmacy
$ 210.95
Trezix coupon at Walgreens Pharmacy
$ 212.62
Trezix coupon at CVS Pharmacy
$ 220.99
$ 221.97

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

Members save the most

Save big on your prescriptions
with the free SingleCare app.
4.8 average rating
About Trezix

      Controlled Substance

Trezix is a prescription drug that is used for the relief of moderate to severe pain. Trezix is a brand-name drug. Acetaminophen-caffeine-dihydrocodeine is the generic version of Trezix. On average, the cost of Trezix is around $349.76. If you want to save when you buy your first prescription or you need a refill of Trezix, you can use a free Trezix coupon or pharmacy coupons from SingleCare to pay a reduced cost of $206.29.

About Trezix

Trezix is a prescription drug that is used for the relief of moderate to severe pain. Trezix is a brand-name drug. Acetaminophen-caffeine-dihydrocodeine is the generic version of Trezix. On average, the cost of Trezix is around $349.76. If you want to save when you buy your first prescription or you need a refill of Trezix, you can use a free Trezix coupon or pharmacy coupons from SingleCare to pay a reduced cost of $206.29.

Trezix FAQs

How much does Trezix cost without insurance?

Without health insurance coverage, the Trezix price can be approximately $349.76. However, you can still earn some prescription savings when you buy Trezix using a free SingleCare Trezix coupon. You can use SingleCare as a savings method option at participating pharmacies like CVS and Kroger. When you use your SingleCare Trezix coupon or discount card, you can pay a reduced price of $206.29 per 60, 320.5-30-16mg capsules for your prescription of Trezix.

How much does Trezix cost with insurance?

The cost of Trezix can be as little as $206.29 if you use a discount card or Trezix coupons from SingleCare. SingleCare savings cards are accepted at local, participating drugstores like CVS, Walmart, Kroger, and Walgreens. You can check with your insurance provider for more informsion on your copay for Trezix. Typically, customers who use SingleCare find that they save more money off the cash price of this prescription drug.

Does Medicare cover Trezix and how much does it cost?

Medicare typically does not cover your prescription of Trezix. Luckily, you can still pay when you pay a reduced price of $206.29 by using a free savings card from SingleCare.

Is there a generic of Trezix?

Trezix is a brand-name drug that is being manufactured by Wraser Pharmaceuticals. The generic version of Trezix is acetaminophen-caffeine-dihydrocodeine.

What is Trezix?

Trezix is a capsule that contains a pain reliever (dihydrocodeine bitartrate), an opioid (narcotic), a non-opioid pain reliever (acetaminophen), and caffeine. This prescription medication is used to help relieve moderate to severe pain. Trezix belongs to the narcotic analgesic combinations class of drugs. Acetaminophen, caffeine, dihydrocodeine bitartrate, and opioid are the active ingredients found in Trezix and this medication works in the brain to change how your body feels and responds to any pain it may feel.

Tell your healthcare provider if you are pregnant or plan to become pregnant as Trezix can be harmful to your unborn baby. Prolonged use of opioid, acetaminophen, caffeine, and dihydrocodeine bitartrate during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if it is not recognized and treated.

What are the side effects of Trezix?

Trezix is a controlled substance and can lead to addiction if taken incorrectly. Do not increase your dose of Trezix without consulting your healthcare provider first. Trezix can also cause dizziness, drowsiness, fever, headache, high fever, itching or skin rash, light-headedness, loss of appetite, nausea, painful or difficult urination, pale skin, pinpoint red spots on the skin, sore throat, sores, ulcers, or white spots on the lips or in the mouth, stomach pain or tenderness, swelling of the feet or lower legs, swollen glands, unexplained or unusual bleeding or bruising, bleeding gums, chest pain, chills, unusual tiredness or weakness, vomiting, and yellow eyes or skin.

If you use Trezix, then the concomitant use of opioids with benzodiazepines or other CNS depressants, including alcohol, may result in respiratory depression, profound sedation, coma, and even death. This is not a full list of possible side effects. Seek medical advice before using Trezix to determine if it is right for you.

Where are Trezix coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.