Key takeaways
Progesterone is a generic prescription drug FDA approved to prevent the uterine lining from getting too thick in people who take estrogen after menopause, but it can also be prescribed for pre-menopausal women who regularly miss their periods (secondary amenorrhea).
The cost of progesterone without insurance is $424 for 90, 100 mg capsules.
Insurance usually covers progesterone for FDA-approved conditions, but people without insurance can save money by using discount coupons, comparing pharmacy prices, or talking to a healthcare professional about lower-priced alternatives.
Progesterone is a generic prescription drug that is FDA approved to prevent uterine lining thickening (endometrial hyperplasia) in postmenopausal women taking estrogen replacement hormones. Healthcare providers may also prescribe it to induce a period in nonpregnant pre-menopausal women who have been missing periods (secondary amenorrhea). Most progesterone 100 mg capsules contain micronized progesterone to allow for better and faster drug absorption. While there aren’t any over-the-counter alternatives, there are many ways to make a progesterone prescription more affordable.
How much does progesterone cost without insurance?
The average cost of progesterone without insurance is approximately $424 for 90, 100 mg capsules. Health insurance can help lower this cost, but your out-of-pocket cost varies depending on your plan. SingleCare discount coupons are available for progesterone and can lower the cost of the drug by up to 80%.
If this cost is too prohibitive, consult your healthcare provider about lower-priced alternatives. Alternative treatments include medroxyprogesterone, levonorgestrel, and norethindrone.
How much does brand-name progesterone cost?
Progesterone is a generic drug, and its brand-name counterpart is Prometrium. The average retail price of Prometrium is $1,836 for 90, 100 mg capsules. A SingleCare prescription discount card can lower this cost by up to 80%.
Compare progesterone prices to related drugs |
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|---|---|---|---|
| Drug name | Price without insurance | SingleCare price | Savings options |
| Generic progesterone | $424 per 90, 100 mg capsules | $33 per 90, 100 mg capsules of generic progesterone at Kroger | See latest prices |
| Prometrium (progesterone) | $1,836 per 90, 100 mg capsules | $1,470 per 90, 100 mg capsules of brand-name Prometrium at Kroger | See latest prices |
| Medroxyprogesterone | $25 per 10, 10 mg tablets | $6 per 10, 10 mg tablets of generic medroxyprogesterone at Kroger | See latest prices |
| Depo-Provera (medroxyprogesterone injection) | $128 for 1, 1 mL of 150 mg/mL syringe | $31 for 1, 1 mL of 150 mg/mL syringe of generic Depo-Provera at Walmart | See latest prices |
| Mirena (levonorgestrel IUD) | $1,725 per 1, 1 intrauterine device | $1,235 per 1, 1 brand-name Mirena intrauterine device at Kroger | See latest prices |
Progesterone costs by dose
The cost of progesterone varies depending on the strength and quantity prescribed. The following table highlights the average retail cost of progesterone by strength.
Compare progesterone prices by strength |
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|---|---|---|
| Strength | SingleCare price of brand-name progesterone | SingleCare price of generic progesterone |
| 100 mg of progesterone | $1,470 for 90 capsules at Kroger | $33 for 90 capsules at Kroger |
| 200 mg of progesterone | $2,790 for 90 capsules at Kroger | $48 for 90 capsules at CVS Pharmacy |
| See our lowest price for progesterone without insurance | ||
Is progesterone covered by insurance?
Most health insurance plans cover progesterone; however, coverage may vary by plan. The same applies to Medicare Part D and Medicare Advantage plans. Ask your healthcare provider or pharmacist if your specific plan covers progesterone.
How to get progesterone without insurance
Depending on the condition being treated, progesterone may need to be taken long-term. This means costs can add up quickly. Fortunately, there are alternatives to paying full price for your progesterone prescription. Here are some dependable ways to save money on progesterone:
1. Use a SingleCare prescription discount card
A SingleCare prescription discount card can lower the cash price of progesterone from $424 to $33 for 90, 100 mg capsules. To save, visit the progesterone coupon page and choose the pharmacy offering the best price with a SingleCare coupon. SingleCare is free to use and available to everyone. Registered members can save even more, and it’s fast and free to join.
RELATED: How do I use the SingleCare app?
2. Discuss lower-cost alternatives with your healthcare provider
Although there are no OTC alternatives to progesterone, there are other generic prescription alternatives that may cost less than progesterone. Examples include medroxyprogesterone acetate and levonorgestrel. However, each drug has its own safety risks, drug interactions, side effects, and warnings. Ask your healthcare provider for medical advice regarding which option is best for you. Your pharmacist can also help compare the costs of each medication.
3. Shop around at different pharmacies
Pharmacies may charge different prices for the same drug. To find the best price, check your local community, chain, and retail pharmacies.
The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Jul. 14, 2026. Prices vary by pharmacy. Visit our coupon page for updated drug prices at pharmacies near you.
- Hormone therapy in postmenopausal women and risk of endometrial hyperplasia, Cochrane Database of Systematic Reviews (2012)
- Progesterone capsule prescribing information, DailyMed (NIH National Library of Medicine) (2026)
- Therapeutic options for management of endometrial hyperplasia, Journal of Gynecologic Oncology (2015)
- Medically accurate: SingleCare’s Medical Review Board analyzes all of our content to confirm it’s in line with current medical advice.
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