Cefdinir alternatives: What can I take instead of cefdinir?

In this article:

• Cefdinir alternatives
• Augmentin
• Zithromax
• Vantin
• Vibramycin
• Cleocin
• Natural alternatives
• How to switch

In this article

• Cefdinir alternatives
• Augmentin
• Zithromax
• Vantin
• Vibramycin
• Cleocin
• Natural alternatives
• How to switch

Cefdinir, known by the brand name Omnicef, is an FDA-approved antibiotic used to treat various types of bacterial infections, including those affecting the sinuses, ears, throat, and skin. While cefdinir works well for many people, some may require an alternative due to allergies, side effects, or antibiotic resistance. If cefdinir isn’t working as it should, a doctor or healthcare provider may recommend another antibiotic.

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What can I take instead of cefdinir?

Cefdinir is a third-generation cephalosporin that works by interrupting the cell wall of bacteria, killing and preventing their growth. Several alternative antibiotics can be used in place of cefdinir, which are just as effective, if not more effective.

Other antibiotics, like other cephalosporins, penicillins, macrolides, tetracyclines, and fluoroquinolones, may be prescribed. Each drug class works differently and has its own dosage schedule, side effects, and spectrum of bacteria it can treat.

The best alternative will depend on the type of infection being treated and the bacteria causing the infection, among other factors. Examples of infectious diseases that may be treated with a cefdinir alternative include:

• Middle ear infections, such as acute otitis media, caused by Streptococcus pneumoniae or Haemophilus influenzae
• Upper respiratory tract infections, such as sinusitis, strep throat (streptococcal pharyngitis), and tonsillitis
• Lower respiratory tract infections, such as chronic bronchitis (exacerbations or flare-ups) and community-acquired pneumonia
• Skin and soft tissue infections, such as mild cellulitis or infections caused by Staphylococcus aureus
• Urinary tract infections (UTIs)

In any case, it’s always important to consult a healthcare provider for medical advice on the most appropriate antibiotic.

Prescription drug prices often change. These are the most accurate medication prices available at the time of publication in ZIP code 23666, as of November 21, 2025. The listed price, without insurance, refers to the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the link under “Savings options” to see the latest drug prices.

Top 5 cefdinir alternatives

The following are some of the most common alternatives to cefdinir.

1. Augmentin (amoxicillin-clavulanate)

Some types of bacteria produce beta-lactamase, an enzyme that renders beta-lactam antibiotics, such as cefdinir, ineffective. Amoxicillin–clavulanate is a broad-spectrum antibiotic that contains clavulanic acid, which works against this enzyme. Therefore, it may be more effective for certain susceptible bacteria for which cefdinir is not effective. Some studies suggest that using cefdinir and amoxicillin-clavulanate together can be effective for complicated infections. Still, amoxicillin may cause more side effects than cefdinir, including diarrhea. 

2. Zithromax (azithromycin) 

Azithromycin is a macrolide antibiotic that may be used for individuals who cannot take penicillins or cephalosporins. Since it’s structurally different from beta-lactam antibiotics like cefdinir, it may be a safe option for individuals with a known allergy to cephalosporins or penicillin. It may also treat certain atypical bacteria, like Mycoplasma and Chlamydophila, that cefdinir doesn’t cover. Most treatment courses are short, making them convenient to use. However, resistance may still be a concern depending on the infection.

3. Vantin (cefpodoxime)

Cefpodoxime is another third-generation cephalosporin antibiotic that healthcare providers may recommend as an alternative to cefdinir. It works against similar types of bacteria, but it has better oral absorption than cefdinir. It may be used for urinary tract infections, sinus infections, community-acquired pneumonia, or skin infections when cefdinir might not provide the same effectiveness.

4. Vibramycin (doxycycline)

Doxycycline is a tetracycline antibiotic that may be used as an alternative to cefdinir. It’s effective against a wide range of bacteria, including atypical bacteria and some MRSA strains. It may be prescribed for skin infections, bronchitis, pneumonia, and tick-borne illnesses. Compared to cephalosporins like cefdinir, doxycycline also has a lower risk of C. Diff infections that can cause severe diarrhea. 

5. Cleocin (clindamycin)

Clindamycin may be an option for people who can’t take beta-lactam antibiotics and need a broader-spectrum antibiotic with coverage against gram-positive bacteria or anaerobes. It’s commonly used for skin and soft-tissue infections, dental infections, and strep throat in patients who have had allergic reactions to cephalosporins. Because it also works against certain MRSA strains, providers may choose it when there’s a resistant staph infection. 

Natural alternatives to cefdinir

There are no over-the-counter or natural antibiotics that can replace a prescription antibiotic like cefdinir. However, certain lifestyle changes and natural products or remedies may help with recovery and managing symptoms of certain infections. These are often recommended in addition to a prescription antibiotic.

• Hydration and rest: Drinking enough fluids and getting enough rest can help support the body during an infection. Neither is a cure on its own, but they can help boost the immune system to help fight an infection.
• Probiotics: Many people take probiotics while they’re on antibiotics to help with stomach-related effects like diarrhea. Studies show they may help replace some of the beneficial bacteria that antibiotics can disrupt.
• Honey: Honey is a home remedy with antimicrobial properties that may help manage a sore throat or cough. It can help coat the throat and soothe discomfort. Adults and pediatric patients over 1 year can try a teaspoon in warm tea or on its own.
• Vitamin C or zinc: These supplements help support the immune system, and some research suggests they help shorten the duration of cold symptoms. They’re not a cure, but some people find them helpful during respiratory infections. 
• Saline nasal rinses or sprays: Saline can help clear out mucus and reduce congestion, especially during sinus infections. A neti pot or squeeze bottle may help make breathing easier during a sinus infection.
• Warm compresses: A warm cloth over the sinuses, jaw, or an irritated area of skin may help reduce pressure or pain. It can be a convenient way to manage discomfort from sinus infections or skin infections.

These home remedies should only be used in conjunction with an antibiotic if one is prescribed. They shouldn’t replace care from a healthcare professional. Bacterial infections may worsen if antibiotics are not taken as prescribed. 

How to switch to a cefdinir alternative

If cefdinir isn’t the right option, a healthcare provider may recommend switching to a different antibiotic. Making the switch should always be done with guidance from a healthcare provider to prevent any interruptions in treatment that could make the infection harder to control. 

Before switching, your provider may consider several factors, including the duration of your illness, the severity of your symptoms, and whether you have recently taken other antibiotics. They may also check for medication allergies, potential drug interactions, and any past reactions to antibiotics. In some cases, especially when symptoms aren’t improving, they may order a throat culture, sputum sample, or urine test to determine which bacteria are causing the problem.

Even if common side effects of cefdinir arise, it’s important not to stop it on your own. A new antibiotic may be started right after stopping cefdinir to ensure there’s no gap in treatment. You’ll also get instructions on dosing, whether to take the new antibiotic with food, and what side effects to watch for.