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Key takeaways
Opzelura (ruxolitinib) is a prescription-only topical cream for atopic dermatitis and vitiligo. It modulates the body’s immune system to treat these conditions.
Opzelura has no generic version and may cost more than other medications used to treat vitiligo and dermatitis.
If Opzelura is not your best choice, talk with your healthcare provider to discuss other therapies for treating atopic dermatitis and vitiligo.
Opzelura is a topical prescription medication intended to treat certain skin conditions. It is available as a cream containing 1.5% of its active ingredient, ruxolitinib, a Janus kinase inhibitor (JAK inhibitor). Opzelura is considered an immunomodulating agent and is approved by the U.S. Food and Drug Administration (FDA) for treating nonsegmental vitiligo and short-term treatment of mild to moderate atopic dermatitis. Vitiligo is a condition where pigment-producing skin cells die, resulting in a loss of skin color. Atopic dermatitis, also called eczema, causes an itchy, painful rash that can range in severity. Opzelura is an option for treating these conditions in people with normal immune systems, especially when other treatments haven’t been effective.
Depending on eligibility and conditions, Opzelura may or may not be covered by your insurance plan. Without insurance, Opzelura has a retail price of $2,839 for one 60-gram tube. You can save with a coupon from SingleCare, which allows you to access your Opzelura prescription for as low as $1,837.
Related: Opzelura dosage
How much does Opzelura cost without insurance?
The retail price for Opzelura without insurance is $2,839 for a 60 gm tube of the 1.5% cream. How long a tube of Opzelura cream lasts will vary for each person, ranging from several weeks to months, depending on the size of the treated skin area. Those who must refill Opzelura more frequently will have higher out-of-pocket costs annually, so it is important to get the best price available. SingleCare offers an Opzelura coupon that will help you compare prices at participating pharmacies and pay the best available price . Unfortunately, there are no generic alternatives to Opzelura at this time. However, you can talk to your healthcare professional about other treatment options that may also treat your condition and be less expensive.
It is important to understand how Opzelura compares to other therapies that treat atopic dermatitis and vitiligo. Price is one factor, but there are others to consider. Opzelura is only approved to treat vitiligo in patients 12 years of age and older. For eczema, Opzelura may be used in children as young as 2 years old.
Opzelura should not be used in patients with:
- An allergy to ruxolitinib
- Active infections
- A history of or risk factors for blood clots
- Breastfeeding
Obzelura should be used with caution in those with:
- Low blood counts
- Compromised immune systems
- A history of tuberculosis (TB), hepatitis, shingles, or recurrent infections
- Chronic conditions such as cardiovascular disease
- Pregnancy
Opzelura has been associated with an increased risk of infections, skin cancers, blood clots, and heart problems. Consult the safety and prescribing information provided by the manufacturer: Opzelura Medication Guide.
How much does brand-name/generic Opzelura cost?
Opzelura is a brand-name drug. There is no generic version available at this time. Opzelura was the first FDA-approved topical drug in its class. A second JAK inhibitor, Anzupgo (delgocitinib), was approved in September 2025 by the FDA to treat moderate to severe eczema. It is also an expensive brand-name drug with no generic alternative.
Here are some topical medications in other drug classes that are also used to treat eczema or vitiligo.
Save up to 80% on Opzelura with SingleCare
Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
|---|---|---|---|
| Opzelura
(ruxolitinib) | $2839 per 1, 60 gm 1.5% tube | $1837 per 1, 60 gm 1.5% tube of brand-name Opzelura | See latest prices |
| Elidel | $400 per 30 gm, 1% cream | $79 per 30 gm, 1% cream of generic pimecrolimus | See latest prices |
| Protopic | $317 per 30 gm, 0.1% ointment | $34 per 30 gm, 0.1% ointment of generic tacrolimus | See latest prices |
| Betamethasone valerate | $85 for 1, 45 gm of 0.1% tube of generic betamethasone valerate | $24.21 for 1, 45gm of 0.1% tube of generic betamethasone valerate | See latest prices |
| Synalar | $797 per 120 gm, 0.025% ointment | $38 per 60 gm, 0.025% ointment of generic fluocinolone | See latest prices |
| Ultravate
(halobetasol) | $1453 per 50 gm, 0.05% cream | $35 per 50 gm, 0.05% generic halobetasol cream | See latest prices |
| Anzupgo (delgocitinib) | $2920 per 30 gm of 20 mg/gm tube | $1944 per 30 gm of 20 mg/gm tube at Kroger | See latest prices |
Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in zip code 23666. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the link under “Savings options” to see the latest drug prices.
Is Opzelura covered by insurance?
Opzelura coverage by insurance plans or Medicare Part D will vary by plan. Coverage may depend on prior authorization, step therapy, or other factors. Your out-of-pocket responsibility will be subject to factors such as deductibles, copays, and out-of-pocket limitations. Your insurance plan will be able to provide more specific information on your coverage for Opzelura. The makers of Opzelura may offer additional savings through an Opzelura copay savings card for eligible patients. Some insurance plans do not qualify for these savings, including those insured by Medicare, Medicaid, or Tricare.
How to get Opzelura without insurance
Paying for Opzelura without insurance can be costly, but there are ways to avoid paying the full retail price. The manufacturer offers a copay savings program, but only some are eligible for these savings or the patient assistance programs. Here are some additional suggestions for saving money on the price of Opzelura:
- Visit SingleCare.com for a free Opzelura coupon. This coupon can provide significant savings (as much as $1000) and lets you know which of your local pharmacies will give you the best price. This eliminates the need to go from pharmacy to pharmacy to price compare.
- Speak to your prescriber and ask if they have samples provided by the manufacturer. It may be preferable to try a small amount from a sample before you choose to pay for Opzelura out of pocket, and it could prevent you from spending if you don’t feel it is the right product for you.
- If you think you may qualify for subsidized insurance plans or Medicaid, work with your local authorities to apply. These plans may provide coverage for Opzelura and cover some or all of your costs.
- FDA approves topical treatment addressing repigmentation in vitiligo in patients aged 12 and older, www.fda.gov (2022)
- Opzelura, www.opzelura.com (2024)
- Opzelura – ruxolitinib cream, National Library of Medicine (2025)