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Oxycodone vs Oxycontin: Main Differences and Similarities

Opioids have become a common aspect of treatment for both acute and chronic pain. Oxycodone and Oxycontin are two opioid medications with similar sounding names that may be easily confused if not examined carefully. In fact, both medications essentially have the same ingredient. Or rather, one medication (Oxycontin) contains the other as an active ingredient (oxycodone). Oxycodone and Oxycontin work by binding to mu receptors in the brain to produce a therapeutic feeling of analgesia. While they may be effective pain medications, they have also been widely publicized for their abuse and potential for addiction.

Oxycodone

Oxycodone is an opioid medication used to treat moderate to severe symptoms of pain. It is metabolized extensively in the body and excreted in the urine. Immediate release oxycodone has a half-life of 3.2 hours and may be dosed up to 4 to 6 times per day. You may be familiar with Oxycodone in combinations with other pain medications such as acetaminophen, ibuprofen, and aspirin. Oxycodone tablets come in immediate release and extended release formulations with varying dosages of 5 mg, 10 mg, 15 mg, 20 mg, and 30 mg.

Oxycontin

Oxycontin is the brand name for the extended-release formulation of oxycodone. This extended-release formulation allows the drug to be released over a longer period of time. For this reason, Oxycontin is usually dosed twice per day because less is needed for the desired pain relief. In this way, Oxycontin tends to give a stronger and more prolonged effect. Oral tablets of Oxycontin come in strengths of 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, and 80 mg.

Oxycodone vs Oxycontin Side by Side Comparison

Oxycodone and Oxycontin are common treatments for the effective management of pain in patients using them for acute or chronic conditions. Both medications have several similarities and differences that are outlined below:

Oxycodone Oxycontin
Prescribed For
  • Moderate to Severe Pain
  • Moderate to Severe Pain
Drug Classification
  • Opioid
  • Opioid
Manufacturer
  • Generic
Common Side Effects
  • Constipation
  • Drowsiness
  • Dizziness
  • Headache
  • Nausea
  • Vomiting
  • Pruritus
  • Lethargy
  • Anxiety
  • Fatigue
  • Chills
  • Irritability
  • Withdrawal symptoms
  • Flushing
  • Hypertension
  • Constipation
  • Drowsiness
  • Dizziness
  • Headache
  • Nausea
  • Vomiting
  • Pruritus
  • Lethargy
  • Anxiety
  • Fatigue
  • Chills
  • Irritability
  • Withdrawal symptoms
  • Flushing
  • Hypertension
Is there a generic?
  • Oxycodone is the generic name
Is it covered by insurance?
  • Varies according to your provider
  • Varies according to your provider
Dosage Forms
  • Oral tablet
  • Oral capsule
  • Oral solution
  • Oral tablet
  • Oral capsule
Average Cash Price
  • $210 (per 120 tablets)
  • $260 (per 60 tablets)
SingleCare Price
Drug Interactions
  • Almivopan
  • Amiodarone
  • Buprenorphine
  • Butorphanol
  • Carbamazepine
  • Erythromycin
  • Ketoconazole
  • MAO inhibitors
  • Nalbuphine
  • Pentazocine
  • Phenytoin
  • Pramipexole
  • Quinidine
  • Rifampin
  • Ritonavir
  • Voriconazole
  • Zolpidem
  • Almivopan
  • Amiodarone
  • Buprenorphine
  • Butorphanol
  • Carbamazepine
  • Erythromycin
  • Ketoconazole
  • MAO inhibitors
  • Nalbuphine
  • Pentazocine
  • Phenytoin
  • Pramipexole
  • Quinidine
  • Rifampin
  • Ritonavir
  • Voriconazole
  • Zolpidem
Can I use while planning pregnancy, pregnant, or breastfeeding?
  • Oxycodone is in Pregnancy Category B. It may not harm an unborn baby but may cause withdrawal symptoms and breathing problems. Consult a doctor regarding steps to take while planning pregnancy. Oxycodone is not recommended while breastfeeding.
  • Oxycontin is in Pregnancy Category B. It may not harm an unborn baby but may cause withdrawal symptoms and breathing problems. Consult a doctor regarding steps to take while planning pregnancy. Oxycontin is not recommended while breastfeeding.

Summary

Both Oxycodone and Oxycontin contain the same active ingredient with differences primarily in their dosage forms. While both drugs share the same side effects, they also carry similar risks of abuse, dependence, and addiction. However, the risk of side effects and overdose may be greater with extended release Oxycontin, especially if it is taken improperly. In instances of more severe pain, Oxycontin may be a more potent option in relieving pain due to its longer duration of action. Because these drugs are Schedule II controlled medications with specific instructions for use, it is important to consult with a physician regarding individualized dosing and drug interactions.