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Key takeaways
Trelegy Ellipta, a combination inhaler approved for treating asthma and COPD in adults, is not yet available in generic form.
Trelegy contains three ingredients: fluticasone furoate, umeclidinium, and vilanterol.
It’s important to tell your healthcare provider if you are struggling to pay for Trelegy because alternative asthma and COPD treatments, including a two-inhaler protocol containing Trelegy’s ingredients, do exist.
If you’re an adult with asthma or chronic obstructive pulmonary disease (COPD, which includes emphysema and chronic bronchitis), you might know that while rescue inhalers are necessary for sudden bronchospasms, daily maintenance inhalers can improve chronic breathing problems. Take Trelegy Ellipta, a once-daily maintenance inhaler. It contains a trio of medication types that decrease inflammation and relax the airways to help prevent exacerbations:
- An inhaled corticosteroid (ICS), fluticasone furoate
- A long-acting muscarinic antagonist (LAMA), umeclidinium
- A long-acting beta2-agonist (LABA), vilanterol
The cost of a brand-name inhaler like Trelegy can add up over time, which is why many people prefer generic treatments.
Is there a generic for Trelegy?
Unfortunately, there is no generic for Trelegy, but there are lower-cost alternatives to discuss with your healthcare provider.
“I do not anticipate the ability to have a generic for Trelegy soon, given it is relatively new to market,” says Fady Youssef, MD, a board-certified pulmonologist, internist, and critical care specialist at MemorialCare Long Beach Medical Center in Long Beach, California.
However, Dr. Youssef says it is possible to get generic versions of Trelegy’s active ingredients, but it would require patients to use two inhalers per day. There simply is no generic inhaler containing all three of Trelegy’s active ingredients.
Why isn’t there a Trelegy generic yet?
Generic drugs hit the market many years after their brand-name counterparts are released. That’s because drug companies like GlaxoSmithKline (GSK), the manufacturer of Trelegy Ellipta, spend a lot of money to create and test the safety and effectiveness of its pharmaceutical products. Once the product is approved by the Food and Drug Administration (FDA), the company maintains patent protections and exclusivity rights on the brand-name medication for several years.
In the case of inhalers, there are actually two patent-protected components: the inhaler device and the medication inside. GSK’s patents for both Trelegy Ellipta’s inhaler technology and medication are not set to expire until 2030.
Trelegy alternatives
Though there is no generic for Trelegy, there are Trelegy alternatives available at lower prices. However, it’s important to note that no single inhaler contains the same three active ingredients as Trelegy.
A two-inhaler treatment plan
Dr. Youssef says if he has a patient who can’t access Trelegy, he considers prescribing two inhalers to cover the three classes of medications (ICS, LABA, and LAMA).
That said, a two-inhaler substitute for Trelegy isn’t a perfect system. “Unfortunately, there are no generic LAMA inhalers,” says Jason Bellak, MD, president and board-certified allergy-immunology physician at Allergy & Asthma Center in Las Vegas, Nevada. “Patients will potentially still have an expensive LAMA inhaler plus the cost of the generic ICS-LABA. So, when you add it up, there may not be much savings, if at all.” Dr. Youssef also says needing to remember two dosage timings creates an increased risk of missed doses. Other concerns to discuss with your prescriber include different common side effects and the potential for allergic reactions.
Bottom line: Both Drs. Bellak and Youssef occasionally prescribe two inhalers to cover Trelegy’s three active ingredients, but it’s not the best solution for everyone. “I do that in select patients where it makes sense financially, dependent upon their insurance,” Dr. Bellak explains.
Generic alternatives
Fluticasone-vilanterol, Wixela Inhub, and Breyna are generic inhalers that contain a corticosteroid and a LABA like Trelegy. However, they do not contain Trelegy’s third medication type: a LAMA. Here’s how they differ:
- Fluticasone-vilanterol: This generic for Breo Ellipta combines the same corticosteroid and LABA as Trelegy Ellipta (fluticasone furoate and vilanterol). It is approved for maintenance treatment of COPD and asthma, and is taken once daily.
- Wixela Inhub (fluticasone propionate/salmeterol): Like Trelegy, Wixela Inhub (brand name: Advair) is a dry powder inhaler approved for asthma and COPD. It contains a slightly different corticosteroid (fluticasone propionate, rather than fluticasone furoate) and a different LABA than Trelegy. It is a twice-daily combination inhaler.
- Breyna (budesonide/formoterol fumarate). Like Wixela Inhub, this Symbicort generic contains a different corticosteroid and LABA than Trelegy. It is also approved for asthma and COPD. Breyna is taken as two inhalations twice daily compared to Trelegy Ellipta’s once-daily inhalation.
Umeclidinium-vilanterol is a generic inhaler for Anoro Ellipta that contains the same anticholinergic and LABA ingredients as Trelegy Ellipta. This medication is only approved for COPD, not asthma, and doesn’t have a steroid.
If Trelegy is not an option, healthcare providers may prescribe two different inhalers that, together, provide all three types of medication—an ICS, a LAMA, and a LABA.
Generic rescue inhalers such as albuterol (brand name: Ventolin HFA) and levalbuterol (brand name: Xopenex) are not appropriate alternatives for Trelegy, as they are used for acute symptoms, not long-term control.
It’s important to understand that this list of generic alternatives for Trelegy is for informational purposes only. Never combine or switch inhalers without the guidance of a healthcare professional. If you are struggling to afford your Trelegy Ellipta prescription, your healthcare provider can discuss the risks versus benefits of switching to a different maintenance treatment to manage asthma symptoms or COPD flare-ups.
How to save on Trelegy
If Trelegy Ellipta is the best prescription drug inhaler for you, there are ways to save until a generic becomes available.
“Manufacturer coupons, patient-assistance programs, or insurance exceptions can make it more affordable, and my team helps patients explore those options every day,” Dr. Youssef says.
If you show your SingleCare prescription discount card or free Trelegy coupon to pharmacy staff when paying, you can lower the cost from $918 for one inhaler (60 blisters of 100mcg/62.5mcg/25mcg, which is a one-month supply) to as low as $534. Exact discounts may vary based on location and pharmacy.
Bottom line
There is currently no generic for the Trelegy Ellipta inhaler, but alternatives exist, and generic options may be available in the future.
If you’re struggling to afford the high cost of Trelegy, your prescriber can offer personalized medical advice and additional information on the right treatment for you. As Dr. Youssef says, “The best inhaler is the one that the patient can access reliably and use regularly.”
The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Dec. 9, 2025. Prices vary by pharmacy. Visit our Trelegy coupon page for updated Trelegy Ellipta prices near you.
- TRELEGY ELLIPTA- fluticasone furoate, umeclidinium bromide and vilanterol trifenatate powder, DailyMed (2023)
- Patenting strategies on inhaler delivery devices, Chest (2023)
- Impact of single combination inhaler versus multiple inhalers to deliver the same medications for patients with asthma or COPD: a systematic literature review, The International Journal of Chronic Obstructive Pulmonary Disease (2020)