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Key takeaways
Trintellix is a brand-name prescription antidepressant.
The Trintellix cost without insurance is about $699 per month.
Many insurance plans cover Trintellix, but uninsured patients can explore alternative treatments like SSRIs and SNRIs.
Other cost-reduction strategies include using a SingleCare discount card, comparing pharmacy prices, or enrolling in patient assistance programs.
Trintellix (vortioxetine) is a brand-name antidepressant used to treat major depressive disorder (MDD). The Trintellix price without insurance is around $699 for a 30-day supply. Currently, there is no lower-priced generic version, but that may change this year (2026). If the Trintellix price is an issue, a healthcare professional can prescribe a different type of generic antidepressant that costs less. If that’s not possible, uninsured patients can still reduce the Trintellix cost through other means.
Save up to 80% on Trintellix with SingleCare
Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
RELATED: Antidepressants coupons and resources
How much does Trintellix cost without insurance?
The cost of Trintellix without insurance is about $699 for a 30-day supply of 30, 20 mg tablets. That works out to $23 per pill. A year of treatment could cost over $8,000.
Trintellix can be prescribed as a first-line treatment for depression, but healthcare professionals typically start with similar, more affordable antidepressants such as SSRIs and SNRIs. Like Trintellix, these drugs increase serotonin in the brain.
If a Trintellix prescription is too expensive, ask the prescriber about SSRIs and SNRIs. They are widely available in affordable generic versions. If these have already been tried, ask about other types of antidepressants, including tricyclic antidepressants, MAO inhibitors (MAOIs), and atypical antidepressants.
Over-the-counter drugs, herbal remedies, and dietary supplements can help improve mood or the occasional blues, but they are not effective substitutes for prescription medications for people with major depressive disorder.
| Compare Trintellix prices to similar atypical antidepressants | |||
|---|---|---|---|
| Drug name | Price without insurance for brand-name drug | SingleCare price | Savings options |
| Trintellix (vortioxetine) | $699 per 30, 20 mg tablets | $491 per 30, 20 mg tablets of brand-name Trintellix at Kroger | See latest prices |
| Viibryd (vilazodone) | $436 per 30, 40 mg tablets | $35 per 30, 40 mg tablets of generic Viibryd at CVS Pharmacy | See latest prices |
| Wellbutrin SR (bupropion sustained-release) | $565 for 60, 150 mg tablets | $6 for 60, 150 mg tablets of generic bupropion SR at Kroger | See latest prices |
| Remeron | $249 for 30, 15 mg tablets | $9 for 30, 15 mg tablets of generic Remeron at Kroger | See latest prices |
| Auvelity (bupropion/dextromethorphan) | $1,567 per 60, 45-105 mg tablets | $1,223 per 60, 45-105 mg tablets at Kroger | See latest prices |
Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of 02/02/2026. Click the link under “See our lowest price” to see the latest drug prices.
Is Trintellix covered by insurance?
Many commercial health insurance plans, Medicare drug plans, Medicaid, and the VA cover Trintellix, but some insurance companies may require prior authorization. The Trintellix out-of-pocket cost with insurance will depend on the plan’s formulary, deductible, copay costs, or coinsurance, if any.
How to get Trintellix without insurance
Most antidepressants are affordable, but new brand-name treatments like Trintellix can be challenging to pay for month after month. Pharmaceutical companies may offer patient assistance programs, rebates, or manufacturer coupons, but eligibility requirements and other hurdles must be met. Fortunately, patient assistance programs and manufacturer offers don’t exhaust all the options. Here are more ways to reduce the cost of Trintellix without insurance.
1. Start by using a SingleCare savings card
With a free Trintellix coupon from SingleCare, people can save over $200 on a 30-day supply. With SingleCare’s bonus loyalty program, people who regularly take advantage of SingleCare discounts can earn additional savings on future purchases and refills.
2. Ask the prescriber about generic antidepressants
Healthcare professionals have a whole arsenal of effective antidepressants to battle depression. Most are available as inexpensive generics, affordable even without health insurance coverage. Unfortunately, many of these will have already been tried before doctors consider Trintellix. Ask the prescriber for medical advice about the pros and cons of switching to less expensive antidepressants.
3. Find the lowest price for Trintellix
All pharmacy prices are not created equal. Finding the lowest Trintellix price could save a significant amount of money, especially when using a SingleCare coupon.
- Trintellix (vortioxetine) prescribing information, (NIH National Library of Medicine) (2025)