Key takeaways
Vyzulta is a brand-name eye drop medication that lowers eye pressure in people with glaucoma or ocular hypertension.
Insurance coverage for Vyzulta varies, with some plans not covering it due to available alternatives.
The Vyzulta cost without insurance is about $354 for a 2.5 mL bottle, but there are ways to save money, including SingleCare coupons, manufacturer coupons, patient assistance programs, or switching to a lower-cost medication.
Vyzulta is a brand-name prescription eye drop medication that reduces eye pressure in people with open-angle glaucoma or ocular hypertension (high eye pressure). The active ingredient in Vyzulta, latanoprostene bunod, is a prostaglandin analog that promotes fluid drainage from the inside of the eye, decreasing eye pressure. The brand-name Vyzulta eye drops price is steep, and there is no Vyzulta generic on the market. However, there are ways to save money on Vyzulta, and below are a few of them.
What is the generic for Vyzulta?
At this time, there is no generic version of Vyzulta ophthalmic solution. The earliest date that a generic version could be available is in 2029.
How much does Vyzulta cost without insurance?
Vyzulta is a brand-name drug that costs more than generic prostaglandin analogs. A 2.5 mL eye dropper bottle costs about $354 at the average retail price. It’s hard to estimate how long that bottle will last. A pharmacist would say that a 2.5 mL bottle contains 50 eye drops, but it may be double that. So, at the recommended dosage, a 2.5 mL bottle should last at least 25 days if both eyes are being treated. At that rate, the yearly cost of Vyzulta treatment works out to around $5,000.
Fortunately, there are generic alternatives. Prostaglandin analogs that work similarly to Vyzulta include latanoprost ($83 for a 2.5 mL bottle), bimatoprost ($267 for 5 mL), and travoprost ($236 for 2.5 mL). All of these drugs work similarly to Vyzulta. However, the eye doctor may have already tried prescribing these drugs before prescribing Vyzulta. If not, ask the prescribing healthcare provider for medical advice about less costly alternatives.
Other types of drugs can also be used, including alpha-adrenergics (brimonidine), beta blockers (timolol), and carbonic anhydrase inhibitors (dorzolamide). Keep in mind that the effectiveness and side effects of these other drugs are different from Vyzulta.
People prescribed Vyzulta may also have to take one or more of these other eye drop medications. In that case, it may be cheaper to take a combination drug rather than take each one separately. If given multiple prescriptions for intraocular pressure (IOP) or glaucoma, ask the ophthalmologist about combination drugs, as they can sometimes help you to save money.
The best way to save money may not be to explore alternative drugs but to use a SingleCare prescription discount card. With SingleCare, the lowest discount price for Vyzulta is only $211 for a 2.5 mL bottle.
Compare Vyzulta prices to related drugs |
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|---|---|---|---|
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
| Vyzulta | $354 per 2.5 mL bottle of 0.024% solution | $211 per 2.5 mL bottle of 0.024% solution of brand-name Vyzulta at Kroger | See latest prices |
| Latanoprost | $83 per 2.5 mL bottle of 0.005% solution | $7 per 2.5 mL bottle of 0.005% solution of generic latanoprost at Kroger | See latest prices |
| Rocklatan
(netarsudil/ latanoprost) |
$482 per 2.5 mL bottle of 0.02-0.005% solution | $287 per 2.5 mL bottle of 0.02-0.005% solution of brand-name Rocklatan at Kroger | See latest prices |
| Rhopressa
(netarsudil dimesylate) |
$435 per 2.5 mL bottle of 0.02% solution | $271 per 2.5 mL bottle of 0.02% solution of brand-name Rhopressa at Kroger | See latest prices |
| Alphagan P
(brimonidine tartrate) |
$291 per 5 mL bottle of 0.15% solution | $66 per 5 mL bottle of 0.15% solution of generic Alphagan P at Kroger | See latest prices |
| Cosopt
(dorzolamide HCl-timolol mal) |
$265 per 10 mL bottle of 2-0.5% solution | $15 per 10 mL bottle of 2-0.5% solution of generic Cosopt at Kroger | See latest prices |
Is Vyzulta covered by insurance?
Some commercial insurance plans and Medicare drug plans provide coverage for a Vyzulta prescription. However, some don’t because of the number of alternative drugs similar to Vyzulta. When covered, Vyzulta may have a high copay cost.
How to get Vyzulta without insurance
A person paying cash for a 2.5 mL bottle of Vyzulta will spend about $354, so saving money may be a top priority. One place to start is to research any patient assistance program offered by the manufacturing pharmaceutical company, Bausch & Lomb. Unfortunately, not everyone can meet the strict enrollment or eligibility requirements. Manufacturer coupons and rebates are the next logical step, but they’re rarely offered. However, there are other options. At the top of the list is using a savings card from SingleCare.
1. Use SingleCare discounts when purchasing prescription medications
A free coupon from SingleCare can reduce the cost of a 2.5 mL Vyzulta bottle to only $211. Other participating pharmacies will have different discount prices, so browse the savings on the Vyzulta coupons page. SingleCare is free to use and available to everyone. Registered members can save even more, and it’s fast and free to join.
2. Find the lowest price
Considerable savings can be found by comparing pharmacy prices, but that entails making a lot of phone calls. Instead, consult SingleCare’s coupon page to see which pharmacies are offering the best Vyzulta coupon near you.
3. Ask your healthcare provider about generic prostaglandin analogs
Switching to a generic drug that works like Vyzulta could net significant savings. There’s a chance that other prostaglandin analogs have been tried already. If they haven’t, ask for medical advice about switching to a lower-priced generic. The first-line treatment is usually latanoprost, with an average cost of $83 for a 2.5 mL bottle. Generic Lumigan (bimatoprost) and generic Travatan Z (travoprost) are also lower-priced alternatives, mainly when purchased at a discount with a SingleCare prescription discount card.
4. Ask your healthcare professional about combination drugs
It’s common for people with ocular hypertension or glaucoma to take more than one eye pressure drug. The expense can add up when these drugs are purchased separately. Instead, ask the prescriber about combination drugs that include a prostaglandin analog combined with another drug. This may be less expensive than the two medications being purchased separately.
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The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Jul. 14, 2026. Prices vary by pharmacy. Visit our coupon page for updated drug prices at pharmacies near you.
- Paragraph IV patent certifications, U.S. Food and Drug Administration (FDA) (2026)
- Use the right drops per mL conversion factor to avoid days’ supply issues, Pharmacist’s Letter (2015)
- An objective assessment of the variability in number of drops per bottle of glaucoma medication, BMC Ophthalmology (2017)
- Vyzulta latanoprostene bunod solution/drops prescribing information, DailyMed (NIH National Library of Medicine) (2024)
- Medically accurate: SingleCare’s Medical Review Board analyzes all of our content to confirm it’s in line with current medical advice.
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