What is Apap-Caff-Dihydrocodeine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Apap-Caff-Dihydrocodeine overview

BRAND NAMES:

  • Trezix

Generic Names:

  • Apap-Caff-Dihydrocodeine

Uses:

  • Treats severe pain. Dihydrocodeine is a narcotic pain reliever.

Therapeutic Classes:

  • Analgesic, Opioid/Acetaminophen Combination

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Apap-Caff-Dihydrocodeine used for?

What form(s) does Apap-Caff-Dihydrocodeine come in

  • Capsule

What are common Apap-Caff-Dihydrocodeine doses?

  • Capsule 320.5-30-16MG

  • Tablet 325-30-16MG

Common Apap-Caff-Dihydrocodeine prescriptions

  • APAP-Caff-Dihydrocodeine
    320.5-30-16mg capsule

  • APAP-Caff-Dihydrocodeine
    325-30-16mg tablet

How to take Apap-Caff-Dihydrocodeine

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Remove the medicine from the original container and mix them with used coffee grounds or kitty litter. Place them in a sealable bag, empty can or container to prevent from leaking.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Remove the medicine from the original container and mix them with used coffee grounds or kitty litter. Place them in a sealable bag, empty can or container to prevent from leaking.

What to do if you miss a dose of Apap-Caff-Dihydrocodeine

Apap-Caff-Dihydrocodeine contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to acetaminophen, caffeine, codeine, or dihydrocodeine, or if you have severe lung or breathing problems or stomach blockage (including paralytic ileus).

Apap-Caff-Dihydrocodeine warnings

  • Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website:www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, breathing problems (such as COPD, sleep apnea), heart disease, gallbladder or pancreas problems, an underactive thyroid, Addison disease, prostate problems, trouble urinating, stomach ulcers, or a history of alcohol or drug abuse, brain tumor, head injury, depression, mental health problems, or seizures.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Do not breastfeed while you are using this medicine, unless you have your doctor's permission to do so.

  • This medicine may make you dizzy or drowsy. Do not drive or doing anything else that could be dangerous until you know how this medicine affects you.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.

  • This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Liver problemsSerious skin reactionsSerotonin syndrome (when used with certain medicines)

Apap-Caff-Dihydrocodeine interactions

  • Do not use this medicine if you are using or have used an MAO inhibitor within the past 14 days.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are using buprenorphine, butorphanol, nalbuphine, pentazocine, or a muscle relaxer.

  • Do not drink alcohol while you are using this medicine. Acetaminophen can damage your liver, and your risk is higher if you also drink alcohol.

  • Some medicines can affect how acetaminophen/caffeine/dihydrocodeine works. Tell your doctor if you are using any of the following:Amiodarone, carbamazepine, disulfiram, erythromycin, isoniazid, ketoconazole, mirtazapine, phenytoin, quinidine, rifampin, ritonavir, tramadol, or trazodoneBlood thinner (including warfarin)Diuretic (water pill)Medicine to treat depression or mental health problems (including bupropion, fluoxetine, paroxetine)Medicine to treat migraine headachesPhenothiazine medicine

Apap-Caff-Dihydrocodeine side effects

Serious Side Effects

  • Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there

  • Blistering, peeling, red skin rash

  • Extreme weakness, shallow breathing, slow heartbeat, sweating, seizures, cold or clammy skin

  • Dark urine or pale stools, loss of appetite, nausea or vomiting, stomach pain, yellow skin or eyes

  • Lightheadedness, dizziness, fainting

  • Blue lips, fingernails, or skin

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Tiredness or sleepiness

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.