Xigduo XR combines two medications: immediate-release dapagliflozin and extended-release metformin. Dapagliflozin and metformin are oral Type 2 diabetes prescription medications that help to control your blood sugar levels in combination with diet and exercise. Xigduo XR is a brand-name drug manufactured by AstraZeneca. The cost of Xigduo XR is about $863.60 for 30, 10-1000mg er 24hr (xr) tablet extended release 24 hours but with a Xigduo XR coupon from the SingleCare discount program, you could pay as little as $363.76 for 30, 10-1000mg er 24hr (xr) tablet extended release 24 hours at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Xigduo XR combines two medications: immediate-release dapagliflozin and extended-release metformin. Dapagliflozin and metformin are oral Type 2 diabetes prescription medications that help to control your blood sugar levels in combination with diet and exercise. Xigduo XR is a brand-name drug manufactured by AstraZeneca. The cost of Xigduo XR is about $863.60 for 30, 10-1000mg er 24hr (xr) tablet extended release 24 hours but with a Xigduo XR coupon from the SingleCare discount program, you could pay as little as $363.76 for 30, 10-1000mg er 24hr (xr) tablet extended release 24 hours at participating pharmacies.
Xigduo XR combines two medications: immediate-release dapagliflozin and extended-release metformin. Dapagliflozin and metformin are oral Type 2 diabetes prescription medications that help to control your blood sugar levels in combination with diet and exercise. Xigduo XR is a brand-name drug manufactured by AstraZeneca. The cost of Xigduo XR is about $863.60 for 30, 10-1000mg er 24hr (xr) tablet extended release 24 hours but with a Xigduo XR coupon from the SingleCare discount program, you could pay as little as $363.76 for 30, 10-1000mg er 24hr (xr) tablet extended release 24 hours at participating pharmacies.
The pricing of Xigduo XR without insurance is around $863.60 for 30, 10-1000mg er 24hr (xr) tablet extended release 24 hours, but your free SingleCare prescription discount card can bring down your total to just about $363.76 for 30, 10-1000mg er 24hr (xr) tablet extended release 24 hours. You can check the SingleCare website to see which local pharmacies accept our free coupons and prescription drug cards to get maximum savings on your next refill.
The copay for Xigduo XR varies by health insurance plan. With SingleCare, the cost of Xigduo XR is $363.76 for 30, 10-1000mg er 24hr (xr) tablet extended release 24 hours. For maximum savings, you can ask your pharmacist to run the SingleCare savings card to compare prices when you are getting your first prescription or a refill of Xigduo XR.
Medicare prescription plan coverage for Xigduo XR depends on your insurance plan, and the copay varies based on your plan’s formulary.
A free SingleCare Xigduo XR coupon may be less expensive than Medicare. Ask your pharmacist to run your SingleCare discount card to compare discounts. With SingleCare, you could pay as little as $363.76 for 30, 10-1000mg er 24hr (xr) tablet extended release 24 hours for Xigduo XR.
Xigduo XR is a brand-name prescription drug for dapagliflozin-metformin manufactured by AstraZeneca. There is not a generic alternative to Xigduo XR.
Xigduo XR is a combination of two medications, dapagliflozin and metformin, which are used to help control blood sugar, along with diet and exercise, in people with Type 2 diabetes. Dapagliflozin, an ingredient in this combination drug, is also FDA-approved to:
Reduce the risk of hospitalization for heart failure in adults with Type 2 diabetes and heart disease (or multiple risk factors for heart disease)
Reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure classified as NYHA class II-IV with reduced ejection fraction
Reduce the risk of kidney problems and cardiovascular death and hospitalization in adults with chronic kidney disease
Xigduo XR (dapagliflozin-metformin) contains two ingredients. Dapagliflozin is classified as an SGLT2 inhibitor. It works by helping the kidneys get rid of glucose. Metformin is a biguanide drug that lowers glucose production in the liver and causes your intestines to absorb less glucose.
You should not use Xigduo XR if you are allergic to either ingredient or similar ingredients. Also, you should not take Xigduo XR if you have moderate to severe kidney problems or are on dialysis. Your healthcare provider will order blood tests to check how well your kidneys work before and during your treatment with this prescription drug. Xigduo XR cannot be used to treat Type 1 diabetes, nor is it recommended to be used by children.
Some—but not all—common possible side effects of Xigduo XR include nausea, vomiting, constipation or diarrhea, back pain, and headache. Dizziness is also common. Stand up slowly when getting up from a sitting or lying down position to minimize dizziness.
Vaginal yeast infections and yeast infections of the penis can also occur. These infections can be serious. Get medical help immediately if you have symptoms in the genital or rectal area such as: burning, itching, odor, pain, tenderness, discharge, swelling, or redness—or if you have a fever or feel ill.
Serious allergic reactions are rare. Get emergency medical attention if you have hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.
Metformin, one of the ingredients in Xigduo XR, can induce ovulation, which can result in unintended pregnancy. If you do not wish to become pregnant, talk to your healthcare provider about effective birth control.
Metformin can also cause a rare but fatal, side effect called lactic acidosis. Lactic acidosis is a dangerous buildup of lactic acid in the blood, and this condition can cause death. Notify your healthcare provider immediately or get emergency medical help if you have muscle pain, difficulty breathing, stomach pain, or dizziness—or if you feel cold, weak, or unusually tired. Avoid alcohol while taking this medication. It can cause low blood sugar and can also increase the risk of lactic acidosis.
This is not a full list of side effects, and others may occur, including serious side effects. Consult your healthcare provider for more information and a full list of adverse effects.
Xigduo XR should be taken once daily in the morning. Take with food to reduce stomach upset. Swallow the tablet whole. Do not cut, chew, or crush the tablet. If you have difficulty swallowing the tablet, notify your healthcare provider.
Xigduo XR may cause weight loss, as seen in clinical studies. The average weight loss among people who took Xigduo XR was about 3%. For example, someone with a starting weight of 200 lbs may lose about 6 lbs while taking Xigduo XR. However, results vary based on individual factors such as other medical conditions and lifestyle changes you make while taking this medication.
Xigduo XR starts working in a few hours, but it may take at least a week to see the full effect of this medication. Ask your healthcare provider for medical advice on how often you should monitor your blood sugar.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved