What is Benazepril: Uses, Warnings & Interactions

Updated Sep 3, 2025  •  Published Dec 30, 2020

Benazepril is a common treatment for high blood pressure. It’s often the first drug doctors use. As an ACE inhibitor, it blocks the body’s production of a hormone (angiotensin) that constricts blood vessels, causing them to relax and widen. Benazepril tablets are taken once or twice daily with or without food.

Benazepril overview

BRAND NAMES:

  • No brand-name versions

Generic Names:

  • Benazepril HCl

Uses:

  • Treats high blood pressure

Therapeutic Classes:

  • Antihypertensive, angiotensin-converting enzyme inhibitor (ACE inhibitor)

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Benazepril used for?

Benazepril treats high blood pressure (hypertension).

What form(s) does Benazepril come in

  • Tablet

    • 5 mg

    • 10 mg

    • 20 mg

    • 40 mg

What are common Benazepril doses?

  • For high blood pressure: 

    • In adults: 10–40 mg tablet taken once daily

    • In children 6 years of age and older: 0.2–0.6 mg/kg given once daily

Common Benazepril prescriptions

  • Benazepril HCl
    10mg tablet

  • Benazepril HCl
    20mg tablet

  • Benazepril HCl
    40mg tablet

  • Benazepril HCl
    5mg tablet

How to take Benazepril

  • Take this medicine as directed. Doses may need to change at the start of therapy.

  • Tablets are taken once or twice daily, depending on the prescription.

  • Take benazepril tablets with food or on an empty stomach.

  • Swallow the tablet whole with a drink of water.

  • Store benazepril tablets in a light-resistant container at room temperature protected from moisture.

What to do if you miss a dose of Benazepril

  • Take a missed dose when it is remembered.

  • If it’s almost time for the next dose, skip the missed dose.

  • Take the next dose at its regular time.

  • Do not take two doses to make up for a missed dose.

Benazepril contraindications

  • This medicine is not right for everyone. 

  • Do not use it if you have:

    • A history of head and neck swelling (angioedema) that has no specific cause

    • Known allergies to benazepril

Benazepril warnings

  • It is not safe to take benazepril while pregnant. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Tell your doctor if you are pregnant, breastfeeding, or if you have:

    • Liver problems

    • Kidney problems

    • Diabetes

    • Heart or blood vessel disease.

  • Tell any doctor or other healthcare provider who treats you that you are taking benazepril.

  • Regular doctor’s visits and blood tests are necessary to monitor the effects of benazepril therapy. Keep all appointments.

  • Benazepril can cause serious problems, including:

    • Low blood pressure

    • High potassium levels

    • Angioedema (severe swelling)

    • Kidney problems

    • Liver problems and liver failure

  • This medicine could lower your blood pressure too much. The risk is greater if you are sweating, dehydrated, salt-depleted, or taking other blood pressure medications or diuretics. Tell the doctor if you experience symptoms of low blood pressure, such as lightheadedness and dizziness, particularly in the first weeks of treatment.

  • Do not stop using this medicine without talking to the prescriber, even if you feel well. You may need to start another medication to keep blood pressure in the normal range.

Benazepril interactions

  • Do not use benazepril with:

    • Aliskiren

    • Entresto (sacubitril/valsartan)

  • To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements you are taking, particularly:

    • Other blood pressure medications, especially angiotensin receptor blockers (ARBs) or other ACE inhibitors

    • Drugs that make you pee (diuretics)

    • Potassium-sparing diuretics such as spironolactone, triamterene, or amiloride

    • Diabetes drugs, including insulin

    • Nonsteroidal anti-inflammatory drugs (NSAIDs

    • Everolimus, gold injections, lithium, sirolimus, tacrolimus, temsirolimus 

  • Tell other healthcare providers you are using this medicine before they prescribe new medications.

  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.

Benazepril side effects

Serious Side Effects

Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:

  • Lightheadedness, dizziness, fainting

  • Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips

  • Change in how much or how often you urinate

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Fever, chills, sore throat, body aches, or other symptoms of an infection

  • Blistering, peeling, sores, red or purple skin rash

  • Allergic reaction: skin rash, hives, itching, facial swelling or puffiness, mouth swelling, swelling or tingling in the throat, chest tightness, difficulty breathing

Benazepril can cause serious side effects that may not have symptoms, including:

  • Injury or death of an unborn baby

  • High potassium

Less serious side effects

  • Headache

  • Dry cough

Sources:

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