Promethazine-Codeine is an FDA approved generic prescription cough syrup that relieves cough and upper respiratory symptoms due to the common cold or allergies. Promethazine is an antihistamine that blocks the action of histamine, a substance that is responsible for causing allergy symptoms like runny nose, sneezing, and itchy, watery eyes. Codeine suppresses coughing by “slowing down” the part of the brain involved with the cough reflex. The retail price for Promethazine-Codeine is $23.00, but a SingleCare discount coupon can reduce the price of Promethazine-Codeine to $14.34 at major retailers, local pharmacies, and supermarkets.
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Prices updated: 12/05/2025
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Promethazine-Codeine is an FDA approved generic prescription cough syrup that relieves cough and upper respiratory symptoms due to the common cold or allergies. Promethazine is an antihistamine that blocks the action of histamine, a substance that is responsible for causing allergy symptoms like runny nose, sneezing, and itchy, watery eyes. Codeine suppresses coughing by “slowing down” the part of the brain involved with the cough reflex. The retail price for Promethazine-Codeine is $23.00, but a SingleCare discount coupon can reduce the price of Promethazine-Codeine to $14.34 at major retailers, local pharmacies, and supermarkets.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Promethazine-Codeine is an FDA approved generic prescription cough syrup that relieves cough and upper respiratory symptoms due to the common cold or allergies. Promethazine is an antihistamine that blocks the action of histamine, a substance that is responsible for causing allergy symptoms like runny nose, sneezing, and itchy, watery eyes. Codeine suppresses coughing by “slowing down” the part of the brain involved with the cough reflex. The retail price for Promethazine-Codeine is $23.00, but a SingleCare discount coupon can reduce the price of Promethazine-Codeine to $14.34 at major retailers, local pharmacies, and supermarkets.
You may pay an average cash price of $23.00 for 120, 6.25mg/10mg/5ml ml of oral solutions of Promethazine-Codeine without insurance, but, with a SingleCare Promethazine-Codeine coupon, you could pay a discount price of only $14.34.
Promethazine-Codeine copay pricing may vary depending on your insurance plan. With SingleCare, Promethazine-Codeine can cost as low as $14.34, so you should ask your pharmacist to compare your SingleCare price with your insurance Promethazine-Codeine copay. A SingleCare savings card typically saves you up to 80% on prescription drugs, which could help you pay a lower cost than your copay with insurance.
Promethazine-Codeine may be covered by some Medicare and insurance prescription drug plans. For patients who have Medicare or insurance coverage, consider bringing your SingleCare Promethazine-Codeine coupon to your pharmacist. With a SingleCare prescription discount card, the price of Promethazine-Codeine could be only $14.34.
Promethazine-Codeine is a prescription drug manufactured by various generic manufacturers. There is no brand-name version currently available.
Promethazine-Codeine is a combination drug used to relieve symptoms of the common cold and allergies. This prescription medication can help treat symptoms like runny nose, cough, and sneezing. It is currently only available as a generic medication.
Promethazine is an antihistamine that helps block the actions of a natural substance called histamine, which is released in response to allergens. Histamine can cause blood vessels to dilate, or widen, in and around the nose, which can lead to symptoms like stuffy and runny nose. Promethazine also has sedative, antiemetic, and anticholinergic effects.
Codeine is an opioid that has pain relieving and cough suppressant properties. Although the exact way in which codeine works is not known, it is believed to work on the cough reflex center in the brain to help suppress cough symptoms. Codeine is a DEA controlled substance that carries a potential for abuse and dependence.
Consult a healthcare provider for the appropriate dosage, administration, and instructions for taking Promethazine-Codeine.
Both promethazine and codeine can cause a number of side effects. The side effects of Promethazine-Codeine may include, but are not limited to, drowsiness, dizziness, lightheadedness, impaired mental and physical performance, headache, dry mouth, and increased sweating. Promethazine-Codeine can also cause nausea, vomiting, constipation, and shortness of breath. Most side effects are mild and go away on their own. Consult a healthcare provider if side effects persist or worsen.
Mental and mood changes are possible and include restlessness, nervousness, anxiety, confusion, disorientation, fatigue, involuntary behaviors, hysteria, and, in rare cases, hallucinations.
Taking Promethazine-Codeine may increase the risk of seizures, low blood pressure, increased pressure in the head, bowel changes, and adrenal gland problems. One rare but possible side effect of taking Promethazine-Codeine is neuroleptic malignant syndrome, a condition that can cause symptoms such as fever, confusion, blood pressure changes, and an increased heart rate. Seek immediate medical attention if you experience any of these side effects.
One of the most serious side effects of codeine is respiratory depression, which is characterized by slowed or stopped breathing and could be fatal. Caregivers should seek emergency medical help if the person taking the medication is breathing slowly, has significant pauses between breaths, has blue lips, or is hard to wake up.
Allergic reactions are not common, but may be associated with symptoms such as rash, swelling, or trouble breathing. You should consult with your prescribing physician about possible side effects of Promethazine-Codeine and any other concerns you may have. Consult a healthcare provider for other possible warnings, precautions, medical advice, and drug information before taking Promethazine-Codeine.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved