What is Carvedilol: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Carvedilol is a generic prescription beta blocker used to treat heart failure, heart attack, and high blood pressure. It is also available under the brand names Coreg and Coreg CR. Carvedilol lowers blood pressure, affects the heart, and improves blood flow. Carvedilol doses are taken as tablets, but healthcare providers can choose between immediate-release tablets for twice-daily dosing or extended-release tablets for once-daily dosing.

Carvedilol overview

BRAND NAMES:

  • Coreg, Coreg CR

Generic Names:

  • Carvedilol

Uses:

  • Treats congestive heart failure and high blood pressure. It also reduces the risk of death after a heart attack.

Therapeutic Classes:

  • Beta blocker, cardiovascular agent, antihypertensive, antiarrhythmic, antianginal

Forms:

  • Tablet, extended-release capsule

How it’s taken:

  • By mouth

What is Carvedilol used for?

Carvedilol is a preferred treatment for people with heart failure with a reduced ejection fraction. That is, the heart's left ventricle chamber does not pump enough blood to the rest of the body. Healthcare professionals also prescribe carvedilol right after a heart attack if the left ventricle is not pumping out enough blood, a condition called left ventricular dysfunction. The FDA also approves carvedilol to reduce high blood pressure. Healthcare professionals commonly prescribe carvedilol off-label to treat some other conditions, such as chest pain (angina).

What form(s) does Carvedilol come in

  • Tablet

    • 3.125 mg

    • 6.25 mg

    • 12.5 mg

    • 25 mg

  • Extended-release capsule

    • 10 mg

    • 20 mg

    • 40 mg

    • 80 mg

What are common Carvedilol doses?

  • For congestive heart failure with reduced ejection fraction: 6.25–50 mg immediate-release tablets twice daily OR 20–80 mg extended-release tablets twice daily.

  • For left ventricular dysfunction after a heart attack: 6.25–25 mg immediate-release tablets twice daily OR 20–80 mg extended-release tablets twice daily.

  • For hypertension: 6.25–25 mg immediate-release tablets twice daily OR 20–80 mg extended-release tablets twice daily.

Find more information about carvedilol dosage, forms, and strengths.

Common Carvedilol prescriptions

  • Carvedilol
    12.5mg tablet

  • Carvedilol
    25mg tablet

  • Carvedilol
    3.125mg tablet

  • Carvedilol
    6.25mg tablet

How to take Carvedilol

  • Take your medicine as instructed. The dose will be changed regularly initially to find the most effective dose.

  • Do not stop taking carvedilol or reduce the dose without talking to the prescriber.

  • Please read the Patient Information sheet that comes with this medicine.

  • Take carvedilol tablets or capsules with food or milk. 

  • Take extended-release capsules only once per day.

  • Swallow carvedilol tablets with a glass of water.

  • Swallow extended-release capsules whole with a glass of water. Do not crush, break, or chew the capsule.

  • If swallowing the capsule is too difficult:

    • Carefully open the capsule.

    • Sprinkle the contents over a spoonful of cool or cold applesauce.

    • Eat the spoonful of applesauce immediately.

  • Store carvedilol tablets or capsules at room temperature in a tightly closed container.

What to do if you miss a dose of Carvedilol

  • If a dose is missed, take it when remembered.

  • If it’s almost time for the next dose, skip the missed dose and take the next dose as scheduled.

  • Do not take two doses to make up for a missed dose.

Carvedilol contraindications

  • This medicine is not right for everyone. 

  • Do not use it if you have had an allergic reaction to carvedilol or if you have:

    • Asthma

    • Severe liver disease

    • Certain heart problems, including AV block, sick sinus syndrome, or a severely slow heart rate

Carvedilol warnings

  • Tell any doctor or other healthcare professional who treats you that you are using carvedilol.

  • The doctor prescribing carvedilol may need to perform regular examinations and tests to monitor your condition and the effects of carvedilol treatment. Keep all appointments.

  • Tell the prescriber if you are pregnant or breastfeeding or if you have:

    • Kidney disease

    • Liver disease

    • Breathing problems such as asthma, bronchitis, emphysema, or similar problems

    • Coronary artery disease

    • Angina (chest pain)

    • Slow or irregular heart rate

    • Circulation problems in the feet or legs

    • Overactive thyroid

    • Diabetes

    • Adrenal gland cancer

    • A history of severe allergic reactions

  • Tell the prescriber if any upcoming surgeries involving anesthesia are scheduled.

  • Tell the prescriber about any scheduled cataract surgery.

  • This medicine may cause the following problems: 

    • Blood sugar changes

    • Slow heart rate

    • Low blood pressure

    • Kidney dysfunction

    • Worsening of heart failure 

  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Do not stop taking carvedilol until consulting with the prescriber. Some people may need the dose to be slowly decreased to prevent serious problems.

Carvedilol interactions

  • To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements you use before carvedilol is prescribed.

  • The doctor should know about specific types of drugs that interact with carvedilol, including:

    • Blood pressure medications, particularly reserpine or calcium channel blockers

    • Drugs that treat irregular heartbeats, particularly amiodarone, propafenone, quinidine, or digitalis drugs such as digoxin

    • Antidepressants, particularly fluoxetine, duloxetine, and paroxetine

    • MAO inhibitors (MAOIs)

    • Cimetidine, clonidine, cyclosporine, fluconazole, rifampin

  • Tell other healthcare providers you take carvedilol before they prescribe new medications or schedule medical procedures or surgery.

Find more detailed information about carvedilol interactions to avoid here.

Carvedilol side effects

Serious side effects

Talk to a healthcare provider if you notice any signs or symptoms of a possible serious side effect, including:

  • Slow, fast, or uneven heartbeat

  • Chest pain or worsening chest pain

  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness

Less serious side effects

  • Dizziness

  • Fatigue

  • Diarrhea

  • Elevated blood sugar

Find more detailed information about carvedilol's side effects here.

Sources:

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