Difluprednate Coupons & Prices

Durezol

Difluprednate is an ophthalmic prescription corticosteroid that reduces ocular inflammation due to surgery or uveitis. It is a potent corticosteroid and is typically used in severe cases or when less potent drugs have not worked. The average pharmacy price for Difluprednate is $301.83 per 1, 5ml of 0.05% bottle. With a SingleCare Difluprednate coupon, the discounted Difluprednate price could be as low as $49.21 for 1, 5ml of 0.05% bottle.

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Difluprednate coupon at CVS Pharmacy
$52.21
$ 49.21
$3 off with signupwith signup

Show this free card to your pharmacist.

This coupon is not insurance.
Difluprednate coupon at Walmart Neighborhood Market Pharmacy
$61.56
$ 58.56
$3 off with signupwith signup
Difluprednate coupon at Walmart Pharmacy
$61.56
$ 58.56
$3 off with signupwith signup
Difluprednate coupon at Publix Pharmacy
$ 66.93
Difluprednate coupon at Walgreens Pharmacy
$84.18
$ 81.18
$3 off with signupwith signup
Difluprednate coupon at Food Lion Pharmacy
$ 101.45
$118.54
$ 115.54
$3 off with signupwith signup
$118.54
$ 115.54
$3 off with signupwith signup
$ 119.99

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 03/11/2026

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About Difluprednate

Difluprednate is an ophthalmic prescription corticosteroid that reduces ocular inflammation due to surgery or uveitis. It is a potent corticosteroid and is typically used in severe cases or when less potent drugs have not worked. The average pharmacy price for Difluprednate is $301.83 per 1, 5ml of 0.05% bottle. With a SingleCare Difluprednate coupon, the discounted Difluprednate price could be as low as $49.21 for 1, 5ml of 0.05% bottle.

Difluprednate Price History & Information

Price History for Difluprednate (Generic) & Durezol (Brand)

1 count, bottle, 5ml of 0.05%

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Difluprednate (Generic) & Durezol (Brand)

1 count, bottle, 5ml of 0.05%
PharmacyDurezol Retail PriceDifluprednate Retail PriceDifluprednate SingleCare Price
CVS Pharmacy$265.00$200.00$50.12
Walmart$269.50$153.48$47.41
Walgreens$267.00$95.00$89.66
Kroger Pharmacy$267.00$215.73$118.55
Albertsons Pharmacy-$148.70$121.60

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Difluprednate

Difluprednate is an ophthalmic prescription corticosteroid that reduces ocular inflammation due to surgery or uveitis. It is a potent corticosteroid and is typically used in severe cases or when less potent drugs have not worked. The average pharmacy price for Difluprednate is $301.83 per 1, 5ml of 0.05% bottle. With a SingleCare Difluprednate coupon, the discounted Difluprednate price could be as low as $49.21 for 1, 5ml of 0.05% bottle.

Difluprednate FAQs

How much is Difluprednate with SingleCare?

The generic of Difluprednate costs $49.21 for 1, 5ml of 0.05% bottle with a free Difluprednate coupon from SingleCare. You could pay even less depending on your prescription information. Use the dropdown menu above to enter your Rx details (i.e., brand/generic, quantity, form, dosage) to see the most accurate prices of Difluprednate with SingleCare near you.

How much does Difluprednate cost without insurance?

Without insurance coverage, Difluprednate will cost $301.83 for 1, 5ml of 0.05% bottle. With a SingleCare Difluprednate coupon, Difluprednate could cost as low as $49.21 for 1, 5ml of 0.05% bottle.

How much does Difluprednate cost with insurance?

People with health insurance may be covered for Difluprednate, but coverage varies. When covered, the copay expense should be low, but some insurance companies may place it in their highest copay tiers. If coverage or cost is an issue, try using a SingleCare Difluprednate coupon without insurance. The lowest SingleCare Difluprednate price is $49.21 for 1, 5ml of 0.05% bottle.

Does Medicare cover Difluprednate?

Many Medicare drug plans cover Difluprednate, but Medicare coverage for Difluprednate varies widely. The out-of-pocket cost may be high because most Medicare plans put Difluprednate in their highest copay tiers. If coverage is denied or out-of-pocket costs are high, use a SingleCare Difluprednate coupon at a participating pharmacy. Our best price for Difluprednate is $49.21 for 1, 5ml of 0.05% bottle. 

Does Medicaid cover Difluprednate?

Many Medicaid plans cover Difluprednate, but some states do not cover the prescription. In addition, states that cover Difluprednate may require prior authorization, so the prescriber will need to provide documentation to support approval. If Difluprednate coverage is turned down, use a SingleCare savings card. Currently, the lowest possible SingleCare price for Difluprednate at participating pharmacies is $49.21 for 1, 5ml of 0.05% bottle.

What is the brand name for Difluprednate?

The brand-name version of Difluprednate is Durezol. It costs about the same as Difluprednate, but it’s less likely to be covered by health insurance plans. 

Ways to save on Difluprednate

Difluprednate is a higher-priced generic drug, but there are only limited ways to save money on generic drugs. The most reliable way to save on Difluprednate is to use a SingleCare discount coupon and get an instant discount when picking up the prescription. Using SingleCare’s savings program routinely can earn bonus savings over time for people who join SingleCare’s bonus loyalty program. 

Other ways to get Difluprednate at a lower cost include enrolling in Medicaid, Medicare Part D Extra Help, or a government-subsidized 340B clinic or hospital.

Comparing pharmacy prices can also produce savings, particularly by comparing SingleCare discount prices at local pharmacies.

Is there a cheaper alternative to Difluprednate?

Ophthalmologists and physicians use ophthalmic corticosteroids to reduce ocular swelling and pain after surgery, in the front part of the eye, or at the surface of the eye. Among the corticosteroids, the cheapest options are ophthalmic dexamethasone or ophthalmic prednisolone. Both are standard first-line treatments. Unfortunately, the most common and cheapest ocular corticosteroids may not be appropriate when Difluprednate is prescribed. Ophthalmologists usually reserve Difluprednate use for severe or refractory cases requiring a more potent steroid.

Although ophthalmic NSAIDs, like ketorolac or diclofenac, reduce swelling and pain, ophthalmologists prescribe them for pain relief or to control macular swelling. They may be appropriate substitutes for corticosteroids if steroid use causes problems, like high eye pressure or drug reactions.

How to use SingleCare for Difluprednate

You can use SingleCare coupons at most national pharmacies and grocery stores, i.e., Walgreens, Kroger, Walmart, CVS, Safeway, and more. Text, email, print, or save your free Difluprednate coupon to your mobile wallet and show your pharmacist at the counter.

Where are Difluprednate coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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