Difluprednate is an ophthalmic prescription corticosteroid that reduces ocular inflammation due to surgery or uveitis. It is a potent corticosteroid and is typically used in severe cases or when less potent drugs have not worked. The average pharmacy price for Difluprednate is $301.83 per 1, 5ml of 0.05% bottle. With a SingleCare Difluprednate coupon, the discounted Difluprednate price could be as low as $49.21 for 1, 5ml of 0.05% bottle.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 03/11/2026
Difluprednate is an ophthalmic prescription corticosteroid that reduces ocular inflammation due to surgery or uveitis. It is a potent corticosteroid and is typically used in severe cases or when less potent drugs have not worked. The average pharmacy price for Difluprednate is $301.83 per 1, 5ml of 0.05% bottle. With a SingleCare Difluprednate coupon, the discounted Difluprednate price could be as low as $49.21 for 1, 5ml of 0.05% bottle.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Durezol Retail Price | Difluprednate Retail Price | Difluprednate SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $265.00 | $200.00 | $50.12 |
| Walmart | $269.50 | $153.48 | $47.41 |
| Walgreens | $267.00 | $95.00 | $89.66 |
| Kroger Pharmacy | $267.00 | $215.73 | $118.55 |
| Albertsons Pharmacy | - | $148.70 | $121.60 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Difluprednate is an ophthalmic prescription corticosteroid that reduces ocular inflammation due to surgery or uveitis. It is a potent corticosteroid and is typically used in severe cases or when less potent drugs have not worked. The average pharmacy price for Difluprednate is $301.83 per 1, 5ml of 0.05% bottle. With a SingleCare Difluprednate coupon, the discounted Difluprednate price could be as low as $49.21 for 1, 5ml of 0.05% bottle.
The generic of Difluprednate costs $49.21 for 1, 5ml of 0.05% bottle with a free Difluprednate coupon from SingleCare. You could pay even less depending on your prescription information. Use the dropdown menu above to enter your Rx details (i.e., brand/generic, quantity, form, dosage) to see the most accurate prices of Difluprednate with SingleCare near you.
Without insurance coverage, Difluprednate will cost $301.83 for 1, 5ml of 0.05% bottle. With a SingleCare Difluprednate coupon, Difluprednate could cost as low as $49.21 for 1, 5ml of 0.05% bottle.
People with health insurance may be covered for Difluprednate, but coverage varies. When covered, the copay expense should be low, but some insurance companies may place it in their highest copay tiers. If coverage or cost is an issue, try using a SingleCare Difluprednate coupon without insurance. The lowest SingleCare Difluprednate price is $49.21 for 1, 5ml of 0.05% bottle.
Many Medicare drug plans cover Difluprednate, but Medicare coverage for Difluprednate varies widely. The out-of-pocket cost may be high because most Medicare plans put Difluprednate in their highest copay tiers. If coverage is denied or out-of-pocket costs are high, use a SingleCare Difluprednate coupon at a participating pharmacy. Our best price for Difluprednate is $49.21 for 1, 5ml of 0.05% bottle.
Many Medicaid plans cover Difluprednate, but some states do not cover the prescription. In addition, states that cover Difluprednate may require prior authorization, so the prescriber will need to provide documentation to support approval. If Difluprednate coverage is turned down, use a SingleCare savings card. Currently, the lowest possible SingleCare price for Difluprednate at participating pharmacies is $49.21 for 1, 5ml of 0.05% bottle.
The brand-name version of Difluprednate is Durezol. It costs about the same as Difluprednate, but it’s less likely to be covered by health insurance plans.
Difluprednate is a higher-priced generic drug, but there are only limited ways to save money on generic drugs. The most reliable way to save on Difluprednate is to use a SingleCare discount coupon and get an instant discount when picking up the prescription. Using SingleCare’s savings program routinely can earn bonus savings over time for people who join SingleCare’s bonus loyalty program.
Other ways to get Difluprednate at a lower cost include enrolling in Medicaid, Medicare Part D Extra Help, or a government-subsidized 340B clinic or hospital.
Comparing pharmacy prices can also produce savings, particularly by comparing SingleCare discount prices at local pharmacies.
Ophthalmologists and physicians use ophthalmic corticosteroids to reduce ocular swelling and pain after surgery, in the front part of the eye, or at the surface of the eye. Among the corticosteroids, the cheapest options are ophthalmic dexamethasone or ophthalmic prednisolone. Both are standard first-line treatments. Unfortunately, the most common and cheapest ocular corticosteroids may not be appropriate when Difluprednate is prescribed. Ophthalmologists usually reserve Difluprednate use for severe or refractory cases requiring a more potent steroid.
Although ophthalmic NSAIDs, like ketorolac or diclofenac, reduce swelling and pain, ophthalmologists prescribe them for pain relief or to control macular swelling. They may be appropriate substitutes for corticosteroids if steroid use causes problems, like high eye pressure or drug reactions.
You can use SingleCare coupons at most national pharmacies and grocery stores, i.e., Walgreens, Kroger, Walmart, CVS, Safeway, and more. Text, email, print, or save your free Difluprednate coupon to your mobile wallet and show your pharmacist at the counter.
SingleCare is accepted at most national pharmacies and grocers, including the following:
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved