What is Neurontin: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Neurontin is a brand-name prescription anticonvulsant that has many uses in healthcare. Its active ingredient, gabapentin, slows down nerve activity, particularly nerves involved with pain. Neurontin is an oral medication available as a tablet, capsule, and oral solution. Doses are taken three times daily.

Neurontin overview

BRAND NAMES:

  • Neurontin

Generic Names:

  • Gabapentin

Uses:

  • Treats seizures and nerve pain caused by shingles

Therapeutic Classes:

  • Anticonvulsant, neuropathic pain agent

Forms:

  • Capsule, tablet, oral solution (liquid)

How it’s taken:

  • By mouth

What is Neurontin used for?

Neurontin has many FDA-approved and unapproved uses in medicine. The FDA has approved Neurontin to relieve pain due to shingles and as an add-on treatment for partial-onset seizures. Healthcare professionals commonly use it off-label for other medical conditions, particularly nerve pain, such as spinal nerve pain, diabetic neuropathy, fibromyalgia, trigeminal neuralgia, and migraine prevention. It’s also used off-label for hot flashes, alcohol withdrawal, bipolar disorder, posttraumatic stress disorder (PTSD), anxiety, itchiness (pruritus), tremors, and muscle spasms due to multiple sclerosis.

What form(s) does Neurontin come in

  • Capsule

    • 100 mg

    • 300 mg

    • 400 mg

  • Tablet

    • 600 mg

    • 800 mg

  • Oral solution (liquid)

    • 250 mg/5 mL

What are common Neurontin doses?

  • For partial-onset seizures in adults and children 12 years or older: 300–600 mg taken three times daily

    • For children 5–11 years old: 25-35 mg/kg (11.4-15.9 mg/lb) per day divided into three daily doses

    • For children 3–4 years old: 40 mg/kg (18.2 mg/lb) per day divided into three daily doses

  • For postherpetic neuralgia in adults: 300–600 mg taken three times daily

Find more information about gabapentin dosage, forms, and strengths here.

Common Neurontin prescriptions

  • Neurontin
    10 capsules bottle

  • Neurontin
    100 capsules bottle

  • Neurontin
    120 capsules bottle

  • Neurontin
    20 capsules bottle

  • Neurontin
    30 capsules bottle

  • Neurontin
    30 tablets bottle

  • Neurontin
    35 capsules bottle

  • Neurontin
    45 capsules bottle

  • Neurontin
    470ml of 250mg/5ml bottle

  • Neurontin
    50 tablets bottle

  • Neurontin
    60 capsules bottle

  • Neurontin
    90 capsules bottle

  • Neurontin
    100mg capsule

  • Neurontin
    300mg capsule

  • Neurontin
    400mg capsule

  • Neurontin
    600mg tablet

  • Neurontin
    800mg tablet

How to take Neurontin

  • Take your medicine as directed. Your dose may need to be changed several times during therapy. 

  • Please read the Medication Guide that comes in the Neurontin package.

  • For epilepsy, take doses at the same times every day. Do not allow more than 12 hours to pass between doses.

  • Gabapentin can be taken with or without food.

  • How to take gabapentin capsules:

    • Swallow the capsule whole with a glass of water. Do not open, crush, or chew it.

    • In situations where the patient cannot swallow the capsule, the doctor may suggest opening the capsule, sprinkling the contents into a small cup of water, juice, or apple sauce, and taking the dose that way. Ask the doctor before doing this.

    • Store Neurontin capsules at room temperature in a closed, child-safe container.

  • How to take Neurontin tablets:

    • Swallow the tablet whole with a glass of water. Do not crush, break, or chew it.

    • The tablets are scored so they can be divided into two doses. Ask a pharmacist or other healthcare provider how to correctly divide tablets.

    • If you break a tablet into two pieces, use the second half as your next dose. Discard any unused half-tablet after 28 days.

    • Store Neurontin tablets at room temperature in a closed, child-safe container.

  • How to take Neurontin oral solution:

    • Shake the closed bottle well before each use.

    • Measure the oral liquid with a syringe or medicine cup with millimeter markings. 

    • Store Neurontin oral solution in the refrigerator in a securely closed container.

What to do if you miss a dose of Neurontin

  • Take a missed dose as soon as you remember it. If it’s almost time for the next dose, skip the missed dose and take the next dose at the proper time.

  • If Neurontin is being taken for epilepsy, do not miss doses. Never allow more than 12 hours to elapse between doses.

  • Never take extra medicine to make up for a missed dose.

Neurontin contraindications

  • This medicine is not right for everyone. 

  • Do not use it if you have had an allergic reaction to gabapentin.

Neurontin warnings

  • Tell any doctor or other healthcare provider who treats you that you are taking gabapentin. This drug may alter the results of some lab tests. 

  • Regular doctor visits are necessary to check the effectiveness of gabapentin treatment. Keep all appointments.

  • Before starting Neurontin, tell the prescriber if you are pregnant or breastfeeding. The prescriber should also know about your medical situation, particularly if you have: 

    • Any history of depression, mood problems, or suicidal thoughts

    • Kidney problems

    • Breathing problems

    • Diabetes

  • Gabapentin is usually safe but can cause serious problems in some people, including:

    • Suicidal thoughts and behaviors

    • Worsening of depression

    • Impairment resulting in injuries or accidents

    • Neuropsychiatric symptoms in children

    • Severe allergic reactions

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Do not stop taking Neurontin doses suddenly. When it’s time to stop taking gabapentin, the prescriber may need to slowly decrease the dose over time.

  • While it’s important to keep medicines out of the reach of children, take extra care with gabapentin.

Neurontin interactions

  • To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements you use, particularly:

  • Do not drink alcohol on the days you take gabapentin.

  • Gabapentin cannot be taken at the same time as an antacid. If you take an antacid, wait at least two hours before you take gabapentin.

Neurontin side effects

Serious side effects

Neurontin can cause serious side effects. Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:

  • Unusual moods or behaviors, thoughts of hurting yourself, feeling depressed

  • Behavior changes, agitation, restlessness, aggression, trouble concentrating, moodiness (especially in children)

  • Increased sleepiness, decreased breathing

  • Blue lips, fingernails, or skin, chest pain, fast heartbeat, trouble breathing

  • Unusual bruising or bleeding

  • Severe tiredness, fatigue, or weakness

  • Sudden muscle pain

  • Yellow skin or eyes

  • Fever, skin rash, swollen neck glands, change in how much or how often you urinate, or bloody or cloudy urine

  • Blistering, peeling, red skin rash

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less serious side effects include:

  • Dizziness

  • Drowsiness

  • Headache

  • Loss of coordination or clumsiness

  • Fatigue

Sources:

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