Zylet Coupons & Prices

Loteprednol

Zylet is a prescription eye drop used to treat eye inflammation caused by allergies, infection, surgery, and other conditions. It works by reducing inflammation and also by fighting bacterial infections. There is no generic version of Zylet currently available. The cost of Zylet is around $454.80 per 1, 5ml of 0.5-0.3% bottle. You can reduce this cost to $330.65 by using a SingleCare Zylet coupon on your next prescription refill at local drugstores, such as CVS and Walgreens.

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Zylet coupon at Kroger Pharmacy
$333.65
$ 330.65
$3 off with signupwith signup

Show this free card to your pharmacist.

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Zylet coupon at Harris Teeter Pharmacy
$333.65
$ 330.65
$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

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Zylet coupon at Walgreens Pharmacy
$341.09
$ 338.09
$3 off with signupwith signup
Zylet coupon at Food Lion Pharmacy
$ 350.76
Zylet coupon at Walmart Neighborhood Market Pharmacy
$358.35
$ 355.35
$3 off with signupwith signup
Zylet coupon at Walmart Pharmacy
$358.35
$ 355.35
$3 off with signupwith signup
$358.83
$ 355.83
$3 off with signupwith signup
$359.86
$ 356.86
$3 off with signupwith signup
$364.51
$ 361.51
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Zylet

Zylet is a prescription eye drop used to treat eye inflammation caused by allergies, infection, surgery, and other conditions. It works by reducing inflammation and also by fighting bacterial infections. There is no generic version of Zylet currently available. The cost of Zylet is around $454.80 per 1, 5ml of 0.5-0.3% bottle. You can reduce this cost to $330.65 by using a SingleCare Zylet coupon on your next prescription refill at local drugstores, such as CVS and Walgreens.

Zylet Price History & Information

Price History for Zylet

1 count, bottle, 5ml of 0.5-0.3%

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Zylet

1 count, bottle, 5ml of 0.5-0.3%
PharmacyZylet Retail PriceZylet SingleCare Price
CVS Pharmacy$399.00$367.00
Walmart$403.25$358.35
Walgreens$353.00$353.00
Kroger Pharmacy$443.50$333.65
Albertsons Pharmacy$417.00$359.85

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Zylet

Zylet is a prescription eye drop used to treat eye inflammation caused by allergies, infection, surgery, and other conditions. It works by reducing inflammation and also by fighting bacterial infections. There is no generic version of Zylet currently available. The cost of Zylet is around $454.80 per 1, 5ml of 0.5-0.3% bottle. You can reduce this cost to $330.65 by using a SingleCare Zylet coupon on your next prescription refill at local drugstores, such as CVS and Walgreens.

Zylet FAQs

Medically reviewed by Josephine BawabPharm.D.
Licensed Pharmacist

How much does Zylet cost without insurance?

The average cost of Zylet without insurance is roughly $454.80, but it could be even more depending on the pharmacy that you use to fill your prescription. Using a SingleCare savings card is one of the easiest ways to save money on the retail price of your prescription drugs. Pay our lowest price of $330.65 on your next Zylet prescription refill by using SingleCare at participating pharmacies.

How much does Zylet cost with insurance?

The cost of prescription medications tends to vary based on the type of health insurance coverage that you have. To find out the cost of Zylet with insurance, you may need to contact your insurance provider directly or speak to your pharmacist. With SingleCare, it is easy for you to save on your medicine. Use our Zylet discount card for a reduced cost of $330.65 per prescription fill of 1, 5ml of 0.5-0.3% bottle.

Does Medicare cover Zylet and how much does it cost?

Medicare Advantage and Medicare Part D plans offer coverage for Zylet. The copay range for Zylet with Medicare is $19-$284. With SingleCare, you may save even more on your prescription costs. Use our free coupons for Zylet and receive instant savings when you pay only $330.65 for your next refill.

Is there a generic of Zylet?

Zylet is only available as a brand-name medication; a generic version is not yet available.

What is Zylet?

Zylet is an FDA-approved prescription eye drop used to treat conditions that cause swelling of the eyes and to prevent and treat bacterial eye infections. This medication contains a combination of tobramycin and loteprednol. Tobramycin is an antibiotic that stops bacteria from growing, while loteprednol helps to reduce redness, swelling, and itching by decreasing inflammation.

This medication is meant to treat eye infections caused only by bacteria. It should not be used for eye infections caused by viruses or fungi. In some cases, it may even worsen them. Unnecessary use and overuse of antibiotics can lead to a decrease in their effectiveness. Speak to your doctor before using Zylet to ensure that this is the most appropriate medication for your condition. Your doctor will also be able to advise you on the best dosage plan for this medication.

What doses of Zylet are available?

Zylet is available as 0.5% of loteprednol and 0.3% of tobramycin. One or two drops of Zylet should be applied into the conjunctival sac of the affected eye(s) every four to six hours. You should use Zylet for the entire time prescribed by your doctor, even if your symptoms have disappeared. If you change your dose of Zylet or stop this medication too soon, it may allow bacteria to continue growing and reinfect the original area being treated.

What are the side effects of Zylet?

Common side effects of Zylet may include brief stinging and burning of the eyes after the medication is applied and headaches. Most people using this medication do not experience any serious side effects. Using Zylet for repeated or prolonged periods of time may result in a new fungal eye infection and may also increase your risk for other eye conditions, such as glaucoma and cataracts.

You should not take this medication for longer than the period of time prescribed by your doctor. Tell your doctor right away if you experience discharge, vision problems, allergic reactions, or eye pain while using this medication. This is not a complete list of side effects. If you have questions about Zylet side effects, ask a healthcare provider for medical advice.

What is a substitute for Zylet?

If Zylet is too expensive or causes too many side effects, speak to your healthcare provider about switching to a similar alternative, such as Blephamide or Maxitrol. Both of these eye drops have an anti-inflammatory component combined with an antibiotic.

Medically reviewed by Josephine BawabPharm.D.
Licensed Pharmacist

Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.

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Where are Zylet coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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