Zylet is a prescription eye drop used to treat eye inflammation caused by allergies, infection, surgery, and other conditions. It works by reducing inflammation and also by fighting bacterial infections. There is no generic version of Zylet currently available. The cost of Zylet is around $454.80 per 1, 5ml of 0.5-0.3% bottle. You can reduce this cost to $330.65 by using a SingleCare Zylet coupon on your next prescription refill at local drugstores, such as CVS and Walgreens.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Zylet is a prescription eye drop used to treat eye inflammation caused by allergies, infection, surgery, and other conditions. It works by reducing inflammation and also by fighting bacterial infections. There is no generic version of Zylet currently available. The cost of Zylet is around $454.80 per 1, 5ml of 0.5-0.3% bottle. You can reduce this cost to $330.65 by using a SingleCare Zylet coupon on your next prescription refill at local drugstores, such as CVS and Walgreens.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Zylet Retail Price | Zylet SingleCare Price |
|---|---|---|
| CVS Pharmacy | $399.00 | $367.00 |
| Walmart | $403.25 | $358.35 |
| Walgreens | $353.00 | $353.00 |
| Kroger Pharmacy | $443.50 | $333.65 |
| Albertsons Pharmacy | $417.00 | $359.85 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Zylet is a prescription eye drop used to treat eye inflammation caused by allergies, infection, surgery, and other conditions. It works by reducing inflammation and also by fighting bacterial infections. There is no generic version of Zylet currently available. The cost of Zylet is around $454.80 per 1, 5ml of 0.5-0.3% bottle. You can reduce this cost to $330.65 by using a SingleCare Zylet coupon on your next prescription refill at local drugstores, such as CVS and Walgreens.
The average cost of Zylet without insurance is roughly $454.80, but it could be even more depending on the pharmacy that you use to fill your prescription. Using a SingleCare savings card is one of the easiest ways to save money on the retail price of your prescription drugs. Pay our lowest price of $330.65 on your next Zylet prescription refill by using SingleCare at participating pharmacies.
The cost of prescription medications tends to vary based on the type of health insurance coverage that you have. To find out the cost of Zylet with insurance, you may need to contact your insurance provider directly or speak to your pharmacist. With SingleCare, it is easy for you to save on your medicine. Use our Zylet discount card for a reduced cost of $330.65 per prescription fill of 1, 5ml of 0.5-0.3% bottle.
Medicare Advantage and Medicare Part D plans offer coverage for Zylet. The copay range for Zylet with Medicare is $19-$284. With SingleCare, you may save even more on your prescription costs. Use our free coupons for Zylet and receive instant savings when you pay only $330.65 for your next refill.
Zylet is only available as a brand-name medication; a generic version is not yet available.
Zylet is an FDA-approved prescription eye drop used to treat conditions that cause swelling of the eyes and to prevent and treat bacterial eye infections. This medication contains a combination of tobramycin and loteprednol. Tobramycin is an antibiotic that stops bacteria from growing, while loteprednol helps to reduce redness, swelling, and itching by decreasing inflammation.
This medication is meant to treat eye infections caused only by bacteria. It should not be used for eye infections caused by viruses or fungi. In some cases, it may even worsen them. Unnecessary use and overuse of antibiotics can lead to a decrease in their effectiveness. Speak to your doctor before using Zylet to ensure that this is the most appropriate medication for your condition. Your doctor will also be able to advise you on the best dosage plan for this medication.
Zylet is available as 0.5% of loteprednol and 0.3% of tobramycin. One or two drops of Zylet should be applied into the conjunctival sac of the affected eye(s) every four to six hours. You should use Zylet for the entire time prescribed by your doctor, even if your symptoms have disappeared. If you change your dose of Zylet or stop this medication too soon, it may allow bacteria to continue growing and reinfect the original area being treated.
Common side effects of Zylet may include brief stinging and burning of the eyes after the medication is applied and headaches. Most people using this medication do not experience any serious side effects. Using Zylet for repeated or prolonged periods of time may result in a new fungal eye infection and may also increase your risk for other eye conditions, such as glaucoma and cataracts.
You should not take this medication for longer than the period of time prescribed by your doctor. Tell your doctor right away if you experience discharge, vision problems, allergic reactions, or eye pain while using this medication. This is not a complete list of side effects. If you have questions about Zylet side effects, ask a healthcare provider for medical advice.
If Zylet is too expensive or causes too many side effects, speak to your healthcare provider about switching to a similar alternative, such as Blephamide or Maxitrol. Both of these eye drops have an anti-inflammatory component combined with an antibiotic.
Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved