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How much is Skyrizi without insurance?

Skyrizi costs $31,096 for a single-dose injector pen (150 mg) and $13,098 for a 600 mg vial. Learn how to get Skyrizi at a lower price or find cheaper alternatives.
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By | Updated on Jun. 20, 2025 Medically reviewed by Ashley Wong, Pharm. D.

Key takeaways

  • Skyrizi is a brand-name prescription drug used to treat plaque psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn’s disease.

  • The price for a three-month supply of Skyrizi without insurance is about $31,000. However, SingleCare’s discount card can lower this amount significantly.

  • Other ways to lower the cost of Skyrizi include switching to a lower-cost treatment or shopping around at different pharmacies.

In this article:

Skyrizi is a brand-name prescription medication FDA-approved to treat moderate-to-severe plaque psoriasis, active psoriatic arthritis, active Crohn’s disease, and active ulcerative colitis. Skyrizi blocks the immune system to control and prevent flare-ups. Subcutaneous injections are self-administered with a single-dose prefilled syringe, pen, or on-body injector. Doctors give intravenous injections as an initial dose for certain conditions. Without insurance, the retail price of Skyrizi is $31,096 for a single-dose injector pen (150 mg). 

 

RELATED: Everything you need to know about biologics for psoriasis

How much does Skyrizi cost without insurance?

The average retail price of Skyrizi is $31,096 for a single-dose injector pen (150 mg) and $13,098 for a 600 mg intravenous injection. That works out to $10,000 per month or $120,000 annually for Skyrizi treatment. A 600 mg vial used as an initial dose for Crohn’s disease costs about $13,098—twice that for the 1,200 mg initial dose for ulcerative colitis. Cartridges for the on-body injector may cost more because of the higher dosage strength.

Health insurance plans can lower the cost. The drug manufacturer, AbbVie, offers a Skyrizi complete savings card, a savings program, and financial assistance programs if drug costs are still prohibitive. However, these options are only available if certain criteria are met. 

No biosimilar versions of Skyrizi are available, but people can consider other lower-priced drugs for plaque psoriasis, psoriatic arthritis, or severe Crohn’s disease. Examples include other biologics such as Humira (adalimumab), immunoregulators such as Otezla (apremilast), and less costly immune suppressants such as methotrexate. Possible side effects, such as injection site reactions, allergic reactions, or respiratory infections, may occur.

RELATED: Skyrizi alternatives: what can I take instead of Skyrizi

What is the generic for Skyrizi?

Skyrizi is a biologic medication (monoclonal antibody). Its active ingredient is risankizumab-rzaa. At this time, no biosimilar versions of Skyrizi are available. The earliest a biosimilar may be available will be in 2031. 

Compare Skyrizi prices to related drugs
Drug name Price without insurance of brand-name drug  SingleCare price Savings options
Skyrizi (risankizumab) $31,096 per 1, 150 mg/mL injection pen $20,238 per 1, 150 mg/mL injection pen of brand-name Skyrizi See latest prices
Otezla (apremilast) $6,561 per 60, 30 mg tablets $4,873 per 60, 30 mg tablets of brand-name Otezla See latest prices
Tremfya (guselkumab) $17,432 per 1, 100 mg/mL pen $12,132 per 1, 100 mg/mL pen of brand-name Tremfya See latest prices
Humira (adalimumab) $9,307 per 2, 1 autoinjector kit boxes $6,009 per 2, 1 autoinjector kit boxes of brand-name Humira See latest prices
Xeljanz (tofacitinib) $7,114 per 1, 60 tablet bottle $5,445 per 1, 60-tablet bottle of brand-name Xeljanz See latest prices
Taltz (ixekizumab) Check specialty pharmacies Check specialty pharmacies Check specialty pharmacies

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs, if available. Click the “Savings options” link to see the latest drug prices.

Is Skyrizi covered by insurance?

According to the drug manufacturer, Skyrizi is a preferred medication for about 99% of commercial insurance plans and 97% of Medicare Part D plans, but drug coverage may depend on the condition being treated. Some Medicaid programs may cover Skyrizi, but this varies by state. Insured patients may still need to pay high copays and other out-of-pocket costs even with insurance coverage. 

How to get Skyrizi covered by insurance

Although Skyrizi is a preferred medication in many insurance plans, the prescription may be denied for several reasons. If it is, talk to the prescriber first. If coverage is denied, you can enroll in a manufacturer-sponsored program to provide free initial doses. Then talk to an insurance representative or consult the plan’s formulary to see if there are special instructions for gaining approval. The insurance company may require prior authorization (PA). The prescriber will fill out a form and submit it to the insurance company. Step therapy (ST) may also be required, meaning that the prescriber must try other drugs before prescribing Skyrizi treatment.

How to get Skyrizi without insurance

Although they are effective treatment options, brand-name biologic medications can be costly. With an annual price tag of $120,000, Skyrizi is no exception. Fortunately, there are alternatives to paying full price for Skyrizi if you don’t have insurance. Here are three ways to save money on doses of Skyrizi: 

1. Use a SingleCare prescription discount card

A SingleCare discount card can lower the cash price of Skyrizi to $20,328 for a three-month injection of Skyrizi compared to $31,096 at the full cash price. Visit the Skyrizi Pen or Skyrizi coupons page and read the FAQs section to find Skyrizi savings and additional information about saving money. You can also earn bonus savings by signing up for SingleCare’s free loyalty program.

2. Discuss other treatments with your healthcare provider

Although Skyrizi is only available as a brand-name drug, alternative medications that may cost less than Skyrizi include other biologics and immunosuppressing drugs. These alternative treatment options may not be ideal because of their effectiveness or serious side effects. Ask a healthcare professional for medical advice about which treatments are right for you. 

3. Compare pharmacy prices

Different pharmacies may charge different prices for the same drug. To find the best price, shop around and compare Skyrizi prices at pharmacies to find the most affordable option.