How much is Skyrizi without insurance?

In this article:

• How much does Skyrizi cost without insurance?
• What is the generic for Skyrizi?
• Is Skyrizi covered by insurance?
• How to get Skyrizi without insurance

In this article

• How much does Skyrizi cost without insurance?
• What is the generic for Skyrizi?
• Is Skyrizi covered by insurance?
• How to get Skyrizi without insurance

Skyrizi is a brand-name prescription medication FDA-approved to treat moderate-to-severe plaque psoriasis, active psoriatic arthritis, active Crohn’s disease, and active ulcerative colitis. Skyrizi blocks the immune system to control and prevent flare-ups. Subcutaneous injections are self-administered with a single-dose prefilled syringe, pen, or on-body injector. Doctors give intravenous injections as an initial dose for certain conditions. Without insurance, the retail price of Skyrizi is expensive, but there are ways to save.

RELATED: Everything you need to know about biologics for psoriasis

How much does Skyrizi cost without insurance?

The average retail price of Skyrizi is $32,566 for a single-dose injector pen (150 mg) and $13,305 for a 600 mg intravenous injection. Cartridges for the on-body injector may cost more because of the higher dosage strength.

Health insurance plans can lower the cost. The drug manufacturer, AbbVie, offers a Skyrizi complete savings card, a savings program, and financial assistance programs if drug costs are still prohibitive. However, these options are only available if certain criteria are met. 

No biosimilar versions of Skyrizi are available, but people can consider other lower-priced drugs for plaque psoriasis, psoriatic arthritis, or severe Crohn’s disease. Examples include other biologics such as Humira (adalimumab), immunoregulators such as Otezla (apremilast), and less costly immune suppressants such as methotrexate. Possible side effects, such as injection site reactions, allergic reactions, or respiratory infections, may occur.

RELATED: Skyrizi alternatives: what can I take instead of Skyrizi

What is the generic for Skyrizi?

Skyrizi is a biologic medication (monoclonal antibody). Its active ingredient is risankizumab-rzaa. At this time, no biosimilar versions of Skyrizi are available. The earliest a biosimilar may be available will be in 2031. 

Compare Skyrizi prices to related drugs
Drug name	Price without insurance of brand-name drug	SingleCare price	Savings options
Skyrizi (risankizumab)	$32,566 per 1, 150 mg/mL injection pen and $13,305 per 600 mg intravenous injection	$20,238 per 1, 150 mg/mL injection pen of brand-name Skyrizi at Walgreens $9,834 per 600 mg intravenous injection at Kroger	See latest prices
Otezla (apremilast)	$6,638 per 60, 30 mg tablets	$4,873 per 60, 30 mg tablets of brand-name Otezla at Kroger	See latest prices
Tremfya (guselkumab)	$17,483 per 1, 100 mg/mL pen	$12,168 per 1, 100 mg/mL pen of brand-name Tremfya at Walgreens	See latest prices
Humira (adalimumab)	$8,978 per 2, 1 autoinjector kit boxes	$6,015 per 2, 1 autoinjector kit boxes of brand-name Humira at Walgreens	See latest prices
Xeljanz (tofacitinib)	$7,497 per 1, 60 tablet bottle	$5,445 per 1, 60-tablet bottle of brand-name Xeljanz at Kroger	See latest prices
Taltz (ixekizumab)	Check specialty pharmacies	Check specialty pharmacies	Check specialty pharmacies

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of Dec. 23, 2025.  

Is Skyrizi covered by insurance?

According to the drug manufacturer, Skyrizi is a preferred medication for about 99% of commercial insurance plans and 97% of Medicare Part D plans, but drug coverage may depend on the condition being treated. Some Medicaid programs may cover Skyrizi, but this varies by state. Insured patients may still need to pay high copays and other out-of-pocket costs even with insurance coverage. 

How to get Skyrizi covered by insurance

Although Skyrizi is a preferred medication in many insurance plans, the prescription may be denied for several reasons. If it is, talk to the prescriber first. If coverage is denied, you can enroll in a manufacturer-sponsored program to provide free initial doses. Then talk to an insurance representative or consult the plan’s formulary to see if there are special instructions for gaining approval. The insurance company may require prior authorization (PA). The prescriber will fill out a form and submit it to the insurance company. Step therapy (ST) may also be required, meaning that the prescriber must try other drugs before prescribing Skyrizi treatment.

How to get Skyrizi without insurance

Although they are effective treatment options, brand-name biologic medications can be costly. With an annual price tag of $120,000, Skyrizi is no exception. Fortunately, there are alternatives to paying full price for Skyrizi if you don’t have insurance. Here are three ways to save money on doses of Skyrizi: 

1. Use a SingleCare prescription discount card

A SingleCare discount card can lower the cash price of Skyrizi to $20,211 for a three-month injection of Skyrizi compared to $32,566 at the full cash price. Visit the Skyrizi Pen or Skyrizi coupons page and read the FAQs section to find Skyrizi savings and additional information about saving money. You can also earn bonus savings by signing up for SingleCare’s free loyalty program.

2. Discuss other treatments with your healthcare provider

Although Skyrizi is only available as a brand-name drug, alternative medications that may cost less than Skyrizi include other biologics and immunosuppressant drugs. These alternative treatment options may not be ideal because of their effectiveness or serious side effects. Ask a healthcare professional for medical advice about which treatments are right for you. 

3. Compare pharmacy prices

Different pharmacies may charge different prices for the same drug. To find the best price, shop around and compare Skyrizi prices at pharmacies to find the most affordable option.