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Key takeaways
Zolpidem tartrate, commonly known as Ambien, is a medication used to treat insomnia. However, it may not be suitable for everyone due to side effects like next-day drowsiness, dizziness, and complex sleep behaviors.
Alternatives include other prescription medications like Lunesta, Zaleplon, Belsomra, DayVigo, and Quviviq.
Over-the-counter medications, certain natural remedies, improving sleep hygiene, and dietary modifications can help treat insomnia without prescription drugs.
Switching from zolpidem to an alternative should involve a healthcare provider to discuss all health conditions, potential withdrawal symptoms, medication interactions, and the continuation of healthy sleep habits.
Zolpidem tartrate (brand name Ambien) is a commonly used prescription medication used to treat insomnia. It works to suppress the part of the central nervous system that maintains wakefulness. Zolpidem is available as immediate-release tablets, extended-release tablets (Ambien CR), sublingual tablets, and capsules. The immediate-release form is prescribed to help people fall asleep at night (sleep onset), while the extended-release form is used to help people fall asleep and stay asleep through the night (sleep maintenance).
While an effective treatment for some people, zolpidem may not be the best or safest option for all people managing insomnia. Common side effects of zolpidem include next-day drowsiness, dizziness, headaches, and decreased mental alertness. Zolpidem is used cautiously in older adults as it can cause driving impairment or accidental injury, such as motor vehicle accidents, falls, or bone fractures. Additionally, zolpidem has a boxed warning that using this medication may cause complex sleep behaviors (including sleepwalking, sleep-driving, and engaging in other activities while not fully awake).
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RELATED: How much is zolpidem tartrate (Ambien) without insurance?
What can I take instead of zolpidem tartrate?
Zolpidem belongs to a group of medications called non-benzodiazepine benzodiazepine receptor agonists (sometimes called Z-drug or non-benzodiazepine hypnotics) that have a sedating effect by slowing down the nerve signals in the brain, which leads to a calming effect. This happens by targeting a chemical in the body called gamma-aminobutyric acid (GABA). As a chemical that calms nerve excitability in the brain, when GABA’s action is boosted, sleep improves. Long-term use of zolpidem should be limited.
Other options are available to treat insomnia and sleep disorders that do not improve with zolpidem. These alternative medications include other non-benzodiazepine hypnotics, orexin receptor antagonists, benzodiazepines, a tricyclic antidepressant (TCA) called doxepin, and the melatonin receptor agonist called ramelteon. These options may suit certain individuals due to their different uses, side effect profiles, and dosages.
| Compare Ambien (zolpidem tartrate) alternatives | |||
|---|---|---|---|
| Drug name | Price without insurance | SingleCare price | Savings options |
| Ambien | $795 per 30, 10 mg tablets | $5 per 30, 10 mg tablets of generic Ambien | See latest prices |
| Belsomra (suvorexant) | $631 for 1, 30-tablet box | $398 for 1, 30 30-tablet box | See latest prices |
| DayVigo (lemborexant) | $456 per 30, 10 mg tablets | $299 per 30, 10 mg tablets | See latest prices |
| Halcion
(triazolam) |
$224 per 2, 0.25 mg tablets | $10 per 2, 0.25 mg tablets of generic Halcion | See latest prices |
| Lunesta (eszopiclone) | $1,265 for 30, 3 mg tablets | $11 for 30, 3 mg tablets of generic Lunesta | See latest prices |
| Quviviq (daridorexant) | $647 for 30, 50 mg tablets | $489 for 30, 50 mg tablets | See latest prices |
| Restoril (temazepam) | $1,254 per 30, 30 mg capsules | $5 per 30, 30 mg capsules of generic Restoril | See latest prices |
| Rozerem (ramelteon) | $526 per 30, 8 mg tablets | $36 per 30, 8 mg tablets of generic Rozerem | See latest prices |
| Silenor
(doxepin) |
$650 per 30, 6 mg tablets | $56 per 30, 6 mg tablets of generic Silenor | See latest prices |
| Zaleplon | $111 for 30, 10 mg capsules | $14 for 30, 10 mg capsules | See latest prices |
Top 5 zolpidem tartrate alternatives
The following are some of the most common alternatives to zolpidem tartrate.
1. Lunesta
Lunesta is a brand-name medication available as a generic medication called eszopiclone. This alternative belongs to the same medication class as zolpidem and works similarly to help people fall asleep and stay asleep through the night. Lunesta is an effective treatment option for insomnia, as clinical trials have shown that compared to a placebo, Lunesta was shown to reduce time to fall asleep by about 12 minutes and wake time after sleep onset by about 17 minutes, resulting in about a half-hour increase of total sleep time per night. Lunesta carries the same boxed warning for complex sleep behaviors and can cause side effects like zolpidem, including headaches, dizziness, and drowsiness. However, Lunesta has the unique side effect of an unpleasant taste in the mouth. The generic and brand names are available as tablets and typically dosed with 1 to 3 mg at bedtime.
RELATED: Lunesta vs. Ambien: Differences, similarities, and which is better for you
2. Zaleplon
Zaleplon is a generic medication (formerly known as the brand-name Sonata) that belongs to the same medication class as zolpidem and is only used for helping people fall asleep, as zaleplon has a quick onset of action. The better action on sleep induction rather than maintenance could be explained by its short half-life and quick onset of action. The American Academy of Sleep Medicine recommends zaleplon as a treatment option for sleep-onset insomnia, so this may be a well-suited alternative for people only experiencing difficulty falling asleep. Zaleplon carries the same boxed warning for complex sleep behaviors and can cause potential side effects like zolpidem, including headache, dizziness, and drowsiness. Zaleplon is available as capsules and is typically dosed with 5 to 10 mg at bedtime.
3. Belsomra
Belsomra (suvorexant) is currently only available as a brand-name medication and belongs to a different class of medications than zolpidem. Belsomra is an orexin receptor antagonist that can help improve sleep onset and maintenance. It was the first medication in this drug class. These medications block the binding of wake-promoting neuropeptides orexin A and orexin B, which is thought to suppress wake drive. Studies have shown that consistent use of Belsomra for one month will decrease the time to fall asleep from an average of 65 to 69 minutes to 32 to 35 minutes. Additionally, Belsomra can help people stay asleep longer than a placebo, as patient diaries show a total sleep time increase of 39 to 43 minutes per night. This alternative may be a great option for people who have not had improved sleep with zolpidem or other Non-benzodiazepine Hypnotics. Belsomra is available as tablets and is usually dosed at 10 to 20 mg at bedtime.
RELATED: Belsomra vs. Ambien: Differences, similarities, and which is better for you
4. DayVigo
DayVigo (lemborexant) is a brand-name medication in the orexin receptor antagonist drug class. DayVigo can help improve sleep onset and maintenance and works by blocking the binding of wake-promoting neuropeptides orexin A and orexin B, which are thought to suppress wake drive. Clinical studies have shown that DayVigo can lead to faster sleep onset and decreased nighttime awakenings. Compared to zolpidem, DayVigo has shown a modest improvement over zolpidem in waking after sleep onset, as DayVigo gave an additional 7 to 9 minutes of sleep before first awakening. This alternative may be a well-suited option for people struggling with sleep problems after trying zolpidem or other Non-benzodiazepine Hypnotics. DayVigo is available as tablets and is usually dosed at 5 to 10 mg at bedtime.
5. Quviviq
Quviviq (daridorexant) is a brand-name medication and is the most recently approved drug in the Orexin Receptor Antagonist medication class. Working to suppress the wake drive like the other drugs in this class, Quviviq helps people fall asleep and stay asleep through the night. In clinical studies, people taking Quviviq reported sleeping better after one week, and improvements continued over 3 to 4 weeks. Like other orexin receptor antagonists, Quviviq may be a good option for people who have not experienced relief from zolpidem or other non-benzodiazepine hypnotics. Quviviq is available as a tablet and is typically dosed with 25 to 50 mg at bedtime.
Natural alternatives to zolpidem tartrate
Alternative zolpidem remedies include supplements, sleep hygiene improvements, and diet modifications to help make falling and staying asleep easier.
Some supplements have evidence of helping treat insomnia, including melatonin, valerian root, and magnesium. Melatonin is a natural hormone made in the body that helps control the sleep-wake cycle. The hormone gets released by the pineal gland in the brain as daylight fades in the evening, which causes tiredness and relaxation. Melatonin is available as a supplement in a variety of formulations, including tablets, gummies, and liquids. Valerian root is an herbal sleep remedy that is available over the counter. Several clinical studies have shown that valerian is effective in the treatment of insomnia, most often by reducing the amount of time it takes to fall asleep. Magnesium is a mineral found in the body, is also found in many foods, and is available as a supplement. While magnesium supplements can be used for treating a variety of conditions, there is limited available evidence for their use in treating insomnia. However, magnesium supplementation for sleep problems may be a suitable option for those who are deficient in magnesium.
According to the American Academy of Sleep Medicine (AASM), sleep hygiene is a series of healthy sleep habits that can improve the ability to fall asleep and stay asleep. Sleep hygiene is an integral part of cognitive behavioral therapy (CBT), the most effective long-term treatment for people with chronic insomnia. CBT for insomnia helps with the thoughts and behaviors that prevent good sleep, stress reduction, relaxation, and sleep schedule management. For diet modifications, the AASM also recommends avoiding caffeine and alcohol in the evening and reducing fluid intake before bedtime.
RELATED: 21 ways to sleep better tonight
How to switch to a zolpidem tartrate alternative
1. Discuss all health conditions with a healthcare provider
Before switching from zolpidem to an alternative, the prescribing doctor must be aware of all medical conditions. Some alternatives should be used with caution or avoided with certain medical conditions.
2. Do not suddenly stop taking zolpidem without medical advice
Only stop taking zolpidem if the prescribing doctor has been consulted and has decided that stopping the medication is safe. If zolpidem is stopped suddenly, there may be sudden withdrawal symptoms and rebound insomnia symptoms. It’s important for a therapy plan to be established prior to stopping zolpidem suddenly. The zolpidem dose should be gradually reduced rather than stopped abruptly whenever possible. Zolpidem withdrawal symptoms include seizures, agitation, tremors, trouble sleeping, and anxiety.
3. Discuss all prescription and over-the-counter medications with a healthcare provider
Before switching from zolpidem to an alternative, it’s important that the prescribing doctor has reviewed a patient’s medication list, including prescription drugs and over-the-counter medications. Some alternative sleeping pills have dangerous drug interactions that must be avoided.
4. Continue to improve sleep hygiene
It’s important for people treating insomnia and other sleep problems to follow healthy sleep habits. Healthcare providers and pharmacists can help give useful sleep hygiene advice, which may include the following tips:
- Keep a consistent sleep schedule. Get up at the same time every day, even on weekends or during vacations, to maintain sleep patterns.
- Set a bedtime that is early enough for at least 7-8 hours of sleep.
- Exercising regularly and maintaining a healthy diet can help improve overall wellness and mental health, which can be affected by sleep difficulties.
- Turn off electronic devices at least 30 minutes before bedtime.
- Avoid consuming caffeine and alcohol in the afternoon or evening. Reduce fluid intake before bedtime.
Choosing the right path for insomnia treatment
Practicing healthy sleep habits can help people fall asleep more easily and stay asleep throughout the night. For people with milder cases of sleep problems, over-the-counter (OTC) sleep medications (such as diphenhydramine, doxylamine, or melatonin) may be helpful. However, if you continue to struggle with insomnia, a healthcare provider can develop an individualized treatment plan that may include a prescription medicine like zolpidem tartrate or an alternative prescription medicine. Prescription options include other Non-benzodiazepine Hypnotics like zaleplon and Lunesta (eszopiclone), or Orexin Receptor Antagonists like Belsomra (suvorexant), Dayvigo (lemborexant), and Quviviq (daridorexant).
- Zolpidem tartrate Prescribing Information, Food and Drug Administration (FDA)
- Lunesta Prescribing Information, FDA
- Zaleplon Prescribing Information, FDA
- Belsomra Prescribing Information, FDA
- DayVigo Prescribing Information, FDA
- Quviviq Prescribing Information, FDA
- Sleep Education: Healthy Sleep Habits, American Academy of Sleep Medicine (2017)
- Over the Counter Sleep Aids, Sleep Foundation (2024)
- Zolpidem Guide to Medication, Young Minds
- Insomnia Treatment, National Heart, Lung, and Blood Institute (2022)
- Veterans Affairs (VA)/Department of Defense (DOD) Practice Guideline for the Management of Chronic Insomnia Disorder and Obstructive Sleep Apnea, Veterans Affairs (VA)/Department of Defense (DOD) (2025)