What is Cidofovir: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Cidofovir overview

BRAND NAMES:

  • Vistide

Generic Names:

  • Cidofovir

Uses:

  • Treats eye infections caused by cytomegalovirus (CMV) in patients who have AIDS.

Therapeutic Classes:

  • Antiviral

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Cidofovir used for?

Cidofovir is an antiviral medication that comes in the form of an intravenous solution. It is used to treat an eye infection called cytomegalovirus retinitis (CMV) in persons with AIDS. Cidofovir is not a cure for CMV or AIDS. Cidofovir is for treating CMV only in people who have AIDS. Do not use Cidofovir if you have moderate to severe kidney disease. Common side effects may include nausea, vomiting, diarrhea, weakness, headache and hair loss.

What form(s) does Cidofovir come in

  • Injectable

What are common Cidofovir doses?

  • Vial 5ML of 75MG/ML

Common Cidofovir prescriptions

  • Cidofovir
    5ml of 75mg/ml vial

How to take Cidofovir

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

What to do if you miss a dose of Cidofovir

Cidofovir contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to cidofovir, probenecid, or any sulfa drug.

Cidofovir warnings

  • This medicine can damage your kidneys. To help prevent damage, you will also take a medicine called probenecid before and after your treatment with cidofovir. It is important that you take probenecid exactly as your doctor ordered. Do not skip any doses.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • If you are pregnant, talk with your doctor before you start this medicine. Cidofovir may be harmful to an unborn baby.

  • Do not get pregnant while you or your sexual partner receive cidofovir. Tell your doctor right away if you do become pregnant while you are being treated with cidofovir.

  • Women should use a reliable method of birth control during treatment and for at least 1 month after the last dose. Men should use a condom during treatment and for at least 3 months after the last dose.

  • You will need to have your eyes and blood counts tested regularly. Keep all appointments.

Cidofovir interactions

  • Some medicines can affect how cidofovir works. Tell your doctor if you are taking zidovudine (AZT), amphotericin B, foscarnet, IV pentamidine, or an antibiotic.

  • Do not get pregnant while you or your sexual partner receive cidofovir. Tell your doctor right away if you do become pregnant while you are being treated with cidofovir.

  • Women should use a reliable method of birth control during treatment and for at least 1 month after the last dose. Men should use a condom during treatment and for at least 3 months after the last dose.

  • This medicine can damage your kidneys. To help prevent damage, you will also take a medicine called probenecid before and after your treatment with cidofovir. It is important that you take probenecid exactly as your doctor ordered. Do not skip any doses.

  • You will need to have your eyes and blood counts tested regularly. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Cidofovir side effects

Serious Side Effects

  • Foamy urine

  • Trouble breathing

  • Unexplained fever, chills, or sore throat

Less Serious Side Effects

  • Hair loss

  • Weakness

  • Diarrhea, nausea, vomiting