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Key takeaways
Humira can cost over $9,000 per month without insurance.
Even with insurance, Humira copays can be high due to deductibles, prior authorization, or step therapy.
Switching to a biosimilar or nonbiologic DMARDs can reduce costs by thousands per month.
Humira is a brand-name prescription biologic used to control the symptoms of various forms of arthritis and inflammatory diseases. Most adults take 40 mg of Humira every other week (two pens or syringes per month). Without insurance, that typically costs $9,000+ per month or more than $100,000 per year. Even with insurance, you may face high deductibles, coinsurance, prior authorization delays, and step therapy requirements. If you’re struggling with the cost of Humira, here are your most effective options.
Switch to a Humira biosimilar
There is no generic for Humira, but there are biosimilar versions of its active ingredient, adalimumab. Currently, there are 10 biosimilar versions of the active ingredient in Humira. You can identify them by the added letters after the drug name, like “adalimumab-ryvk.” These biosimilars are sometimes more affordable than Humira.
Adalimumab, the active ingredient in Humira, is a human monoclonal antibody that suppresses the immune system. The good news is that there are several biosimilar versions of adalimumab. These are versions that have minor changes in the adalimumab molecule that don’t affect its ability to control autoimmune diseases.
Completely interchangeable biosimilars:
Nearly interchangeable biosimilars:
RELATED: Cyltezo vs. Humira
Note: Some biologics, like Enbrel, Cimzia, and Symponi, are just as expensive, or even more expensive, than Humira.
Compare Humira prices to biosimilars |
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|---|---|---|---|---|
| Drug name | Type of alternative | Price without insurance | SingleCare price | Savings options |
| Humira (adalimumab) | Brand name | $9,092 for 2 auto-injector kits | $6,042 for 2 auto-injector kits of brand-name Humira at Kroger | See latest prices |
| Cyltezo (adalimumab-adbm) | Biosimilar (completely interchangeable) | $7,812 for 2 auto-injector kits | $1,288 for 2 auto-injector kits of generic Cyltezo at Kroger | See latest prices |
| Simlandi (adalimumab-ryvk) | Biosimilar (completely interchangeable) | $1,526 for 2 auto-injector kits | $1,017 for 2 auto-injector kits of generic Simlandi at Kroger | See latest prices |
| Abrilada (adalimumab-afzb) | Biosimilar (completely interchangeable) | $1,380 for 1 auto-injector kit | $1,017 for 1 auto-injector kit of brand-name Abrilada at Kroger | See latest prices |
| Hyrimoz (adalimumab-adaz) | Biosimilar (nearly interchangeable) | $2,002 per 2, 2 mL of 40 mg/0.4 mL pens | $1,259 per 2, 2 mL of 40 mg/0.4 mL pens of generic Hyrimoz at Kroger | See latest prices |
Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of Feb. 11, 2026. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.
Consider lower-cost nonbiologic DMARDs
Humira biosimilars still cost $1,000+ per month. If biosimilars are still unaffordable, ask your prescriber about corticosteroids or nonbiologic DMARDs, which often have a cheaper generic available. These may include:
These are not identical to Humira, so they may not be appropriate for everyone.
RELATED: What can I take instead of Humira?
Is Humira covered by insurance?
Humira is partially covered by most commercial health insurance plans, some Medicare prescription plans, and some Medicaid plans. Some plans that do not cover Humira may cover a Humira biosimilar; check your insurance provider’s formulary. Even with coverage, restrictions may apply, such as prior authorization, step therapy, or a requirement to use a specific pharmacy.
RELATED: Does Aetna cover Humira? | Does Blue Cross cover Humira?
How to get Humira covered by insurance
If your insurance denies coverage or your copay is too high, you have options.
Ask your doctor to:
- Submit prior authorization paperwork
- File a formulary exception
- Submit a tiering exception to lower your copay tier for a nonpreferred drug
- Appeal a denial
For Medicare patients:
- Monthly costs may reach $2,000+, depending on your coverage phase
- If you’re eligible, Extra Help can reduce costs
The manufacturer, AbbVie, also offers Humira discounts with insurance. Contact the manufacturer to find out if you’re eligible.
How to save money on Humira without insurance
Most people have little room in their budgets to pay more than $100,000 a year for Humira. Insurance coverage will help, but the out-of-pocket cost could be high, and insurance requirements may cause a lag in coverage. However, uninsured people can get Humira or a nearly identical drug at a more affordable price without manufacturer coupons, rebates, or enrollment in the manufacturer’s patient assistance program. Here’s how:
1. Ask about switching to a biosimilar
While there is no generic version of Humira, biosimilars are the next best thing. With a SingleCare discount card, the cheapest of these biosimilars can cost about $1,000 per month – an annual savings of $96,000 in comparison with Humira.
2. Compare pharmacy prices every refill
Use SingleCare to compare Humira prices at pharmacies near you. At the time of publication, there is a $1,000+ difference between pharmacies in Hampton, VA (zip code 23666). Prices often fluctuate, so it’s best to compare prices at local pharmacies before each refill.
3. Use a discount card
SingleCare offers free coupons for Humira that do not require prior authorization, step therapy, or a specific pharmacy. These coupons can be used on every refill – they do not expire. At the time of publication, you can save up to $3,050 on 2 auto-injector kits of Humira with a SingleCare savings card.
Signing up for SingleCare is always optional, but registered members unlock our lowest prices for Humira and other prescriptions. Registered members earn bonus savings on every prescription filled with SingleCare that can be applied to your discount.
4. Ask about switching to nonbiologic DMARD alternatives
When all options have been tried, get medical advice from a healthcare professional about switching to a generic nonbiologic DMARD that is FDA-approved for the condition you have. These drugs are significantly cheaper, starting at $78 without insurance and $13 with SingleCare. To get affordable treatment, you may need to return to a drug that you’ve already used or switch to a drug that hasn’t been tried.
The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Feb. 11, 2026. Prices vary by pharmacy. Visit our Humira coupon page for the latest Humira prices near you.
- Humira, AbbVie Inc.
- Humira biosimilars, FDA Purple Book Database of Licensed Biological Products