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Key takeaways
Entresto is a premium-priced heart failure medication, but a lower-priced generic version is available.
Nearly all insurance policies cover Entresto or its generic version. Even with insurance, the out-of-pocket cost for brand-name Entresto may be high.
Insured and uninsured patients can save money on an Entresto prescription with a SingleCare discount card, price shopping, or switching to the generic version.
Entresto is a brand-name prescription drug used to reduce the risk of serious cardiovascular events and hospitalization in adults and children with chronic heart failure. A combination of two drugs, sacubitril and valsartan, Entresto relaxes blood vessels and reduces blood pressure, leading to reduced strain on the heart and slowing the progression of heart failure. Entresto is a higher-priced, brand-name medication, but people without insurance have a number of options for saving money.
How much does Entresto cost without insurance?
The average retail price for Entresto without insurance is $969 for 60, 24/26 mg tablets. Since Entresto tablets are taken twice a day, 60 tablets are enough medicine for a 30-day supply. That means each tablet costs about $16. Each day’s treatment costs on average $32. Heart failure medications like Entresto are prescribed for months or years, so people without insurance coverage should expect to pay over $11,000 a year for Entresto.
Cost is a valid reason to seek Entresto alternatives. Other common reasons for switching medications are troublesome or serious side effects, if you have a contraindication and cannot take Entresto (such as kidney problems, allergic reactions, pregnancy, or breastfeeding), or if you take a drug that interacts with Entresto.
RELATED: Side effects of Entresto
While one of the drugs in Entresto, valsartan, is widely available in generic versions, sacubitril is only found in Entresto. Entresto is a one-of-a-kind drug and the only member of its class (angiotensin receptor-neprilysin inhibitors or ARNIs).
There are no over-the-counter drugs or supplements that can effectively treat heart failure in place of prescription medications. And although there are no alternatives available within the same drug class as sacubitril, other FDA-approved medications can treat heart failure. Some of them are available in more affordable, generic versions. These include drug classes such as diuretics, ACE inhibitors, beta blockers, sodium-glucose cotransporter 2 (SGLT2) inhibitors, and angiotensin II receptor blockers (ARBs). Before stopping Entresto, consult your healthcare provider about the following heart failure medications and whether they could work for you.
Compare Entresto prices to related drugs |
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|---|---|---|---|
| Drug name | Price without insurance | SingleCare price | Savings options |
| Entresto (sacubitril/valsartan) | $969 per 60, 24/26 mg tablets | $50 per 60, 24/26 mg tablets of generic Entresto at CVS | See latest prices |
| Diovan (valsartan) | $1,136 per 90, 160 mg tablets | $29 per 90, 160 mg tablets of generic Diovan at Kroger | See latest prices |
| Vasotec (enalapril) | $1,003 per 30, 20 mg tablets | $9 per 30, 20 mg tablets of generic Vasotec at Walmart | See latest prices |
| Coreg (carvedilol) | $1,135 per 60, 12.5 mg tablets | $6 per 60, 12.5 mg tablets of generic Coreg at Kroger | See latest prices |
| BiDil (isosorbide dinitrate/hydralazine) | $473 per 90, 20/37.5 mg tablets | $65 per 90, 20/37.5 mg tablets of generic BiDil at CVS | See latest prices |
| Aldactone (spironolactone) | $109 per 30, 25 mg tablets | $4 per 30, 25 mg tablets of generic Aldactone at Kroger | See latest prices |
| Farxiga (dapagliflozin) | $822 per 30, 10 mg tablets | $361 per 30, 10 mg tablets of generic Farxiga at Walgreens | See latest prices |
Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of November 18, 2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the link under “Savings options” to see the latest drug prices.
RELATED: Entresto alternatives: What can I take instead of Entresto?
Entresto costs by dose
Entresto is a premium-priced brand-name medication, so prices do not vary by dosage strength. Entresto is only packaged in quantities of 60 tablets and typically dispensed from the pharmacy as a 30-day supply, so savings are usually not feasible by seeking out 90-day supplies of the drug.
Compare Entresto prices by strength |
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|---|---|---|
| (per 60 tablets) | ||
| Strength | SingleCare price of brand-name Entresto | SingleCare price of generic Entresto |
| 24-26 mg of Entresto | $692 at Walgreens | $50 at CVS |
| 49-51 mg of Entresto | $691 at Walgreens | $50 at CVS |
| 97-103 mg of Entresto | $691 at Walgreens | $50 at CVS |
| See our lowest price for Entresto without insurance | ||
Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of November 18, 2025.
Save up to 80% on Entresto with SingleCare
Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
Is Entresto covered by insurance?
Nearly all commercial and private insurance plans, Medicare Part D plans, and state Medicaid plans cover Entresto or its generic version, sacubitril-valsartan. Insurance providers generally do not require prior authorization, but they may reject an Entresto prescription if the generic version hasn’t been tried.
Health insurance can significantly reduce the cost of Entresto, but the out-of-pocket cost will depend on the plan’s deductible and the copay cost determined by the plan’s formulary. For additional savings, Novartis Pharmaceuticals, the manufacturer of Entresto, has a copay offer for people on Medicare or commercial health insurance.
How to get Entresto without insurance
Paying for an Entresto prescription without insurance will be challenging. With a total calendar year cost approaching $11,000, Entresto can be a significant financial responsibility for people without insurance. The manufacturer may offer patient assistance programs, but not everyone will meet the strict eligibility requirements. Fortunately, there are a variety of ways to save money on Entresto.
1. Save instantly with a SingleCare savings card
In just a few minutes, people could save hundreds of dollars by using a free Entresto coupon from SingleCare. For example, a 30-day supply of generic Entresto costs $50 at CVS with SingleCare. Read the FAQs section on the Entresto coupon page for additional information about paying for Entresto. For additional savings on refills and future drug purchases, join SingleCare’s bonus loyalty program.
2. Switch to generic Entresto
A 30-day supply of generic sacubitril-valsartan costs $255 on average without insurance. A SingleCare savings card can reduce the cost to as little as $50 at CVS. That’s $900 less than the average cost of Entresto tablets. Most people with insurance will start with generic Entresto, so it makes sense for uninsured patients to start treatment the same way.
3. Look for the lowest price
Entresto has a manufacturer’s list price, but the actual price charged by the pharmacy is usually higher … sometimes much higher. Check with several pharmacies before filling an Entresto prescription.
4. Ask the prescriber about alternative heart failure treatments
Entresto is the only prescription drug available that contains sacubitril. There is no other drug that works like sacubitril. However, there are other drug combinations used to treat heart failure, drugs that can be purchased as lower-cost generics. If Entresto is too expensive, ask a healthcare provider for medical advice about lower-priced drug combinations.
- Entresto, Novartis Pharmaceuticals
- Entresto HCP, Novartis Pharmaceuticals
- Entresto sacubitril and valsartan tablet prescribing information, DailyMed (NIH National Library of Medicine)
- AHA/ACC/HFSA guideline for the management of heart failure, American College of Cardiology/American Heart Association Joint Committee on Clinical Practice (2022)