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Key takeaways
Sertraline is a generic prescription antidepressant that costs about $75 without insurance for a 30-day supply.
Most health insurance plans, including Medicare and Medicaid, typically cover sertraline, but out-of-pocket costs vary by plan.
Save money on sertraline by using a SingleCare discount card, comparing pharmacy prices, or utilizing 340B providers or community health clinics.
Sertraline, better known by its brand name, Zoloft, is a generic prescription drug used for depression and anxiety conditions. The FDA has approved sertraline as a treatment for major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder. The sertraline price without insurance is about $75 per month, but there are ways to save money.
RELATED: Antidepressant coupons and resources
Is sertraline covered by insurance?
Most commercial health insurance plans, Medicare Part D drug plans, and Medicaid will cover a generic sertraline prescription.
How much does sertraline cost without insurance?
Sertraline is a moderately priced generic drug, but it may be challenging to pay for month after month. Uninsured buyers will pay an average retail price of $75 for a 30-day supply of 50 mg tablets, about $450 for six months of treatment.
The prescribed dosage can affect the cost. The maximum daily dose of sertraline is 200 mg. People taking sertraline in tablet form will take two 100 mg tablets, doubling their monthly cost. Sertraline capsules are sold in 150 mg and 200 mg doses, and they may be more expensive than tablets.
People with health insurance will typically find sertraline classified as a low-copay Tier 1 drug. However, the actual out-of-pocket costs depend on the health plan’s deductible, coinsurance percentage, and other factors.
Sertraline is one of the higher-priced SSRIs, so ask the prescribing healthcare provider about alternative antidepressants that may be cheaper. It is best for you to consult your insurance formulary before requesting a change in medication to ensure the prescribed medication is less out-of-pocket for you than sertraline. This includes fluoxetine or another type of antidepressant or anxiety medication. Make sure you get medical advice from a healthcare professional before switching between SSRIs or antidepressant classes.
RELATED: Zoloft alternatives for depression and anxiety
Compare sertraline prices to related drugs |
|||
|---|---|---|---|
| Drug name | Price without insurance for brand-name drug | SingleCare price | Savings options |
| Generic Zoloft (sertraline) | $75 for 30, 50 mg tablets of generic Zoloft | $9 for 30, 50 mg tablets of generic Zoloft at Kroger | See latest prices |
| Zoloft
(sertraline) |
$551 for 30, 50 mg tablets | $9 for 30, 50 mg tablets of generic Zoloft at Kroger | See latest prices |
| Celexa (citalopram) | $407 for 30, 20 mg tablets | $6 for 30, 20 mg tablets of generic Celexa at Kroger | See latest prices |
| Fluoxetine | $67 for 30, 20 mg capsules | $6 for 30, 20 mg capsules of generic fluoxetine at Kroger | See latest prices |
| Paxil
(paroxetine) |
$760 for 30, 20 mg tablets | $4 for 30, 20 mg tablets of generic Paxil at Walmart | See latest prices |
| Lexapro (escitalopram) | $571 for 30, 10 mg tablets | $9 for 30, 10 mg tablets of generic Lexapro at Kroger | See latest prices |
RELATED: Everything you should know about generic Zoloft
How to get sertraline without insurance
Sertraline’s price is not burdensomely high, but the monthly cost over time might be challenging. At high dosages, the sertraline cost could be even higher. It may be possible to find nonprofit patient assistance programs, but they often involve eligibility requirements and time-consuming enrollment procedures. Manufacturing coupons are another possible option, but they are rarely offered on lower-priced generic drugs. Fortunately, people without insurance have other ways to bring the monthly cost of a sertraline prescription down to only a few dollars, starting with a SingleCare discount card.
1. Use a SingleCare savings card
No matter the dosage, a free SingleCare coupon can reduce the monthly cost of sertraline 50 mg or 100 mg to less than $10. Join SingleCare’s bonus loyalty program to earn even bigger savings. Each SingleCare purchase adds up to bonus savings on future purchases and refills.
Save up to 80% on Sertraline with SingleCare
Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
2. Combine a 90-day prescription with a SingleCare savings card
With some exceptions, there’s little to be saved by filling a 90-day sertraline prescription at a pharmacy at retail price. However, combine a 90-day prescription with a SingleCare savings card, and you may save money per tablet at the lowest SingleCare discount prices.
2. Shop for the lowest price
Different pharmacies charge different prices for the same sertraline prescription. For sertraline, the difference could be as much as $47 for a one-month supply.
3. Find a 340B provider or community health clinic to help with the prescription
Prescription medication savings can often be found at community health clinics and 340B providers. Some of them may have income or residency eligibility requirements, but they often sell generics at very low prices. Ask the prescriber or contact a local health department for a complete list in your area.
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The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Apr. 17, 2026. Prices vary by pharmacy. Visit our coupon page for updated drug prices at pharmacies near you.
- Sertraline hydrochloride capsule prescribing information, DailyMed (NIH National Library of Medicine) (2025)
- Sertraline tablet prescribing information, DailyMed (NIH National Library of Medicine) (2023)