The FDA has approved Divigel (estradiol gel) to treat certain symptoms of menopause including hot flashes, night sweats, and vaginal dryness. It is a gel that's absorbed through the skin to provide the body with estrogen and treat moderate to severe menopausal symptoms.
On average, the cost of Divigel is $446.22 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. However, you can reduce this cost by using SingleCare's free discount card or the Divigel coupons that you'll find here. Pay just $35.58 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box when you use your Divigel coupons at any of the participating pharmacies in the United States.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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The FDA has approved Divigel (estradiol gel) to treat certain symptoms of menopause including hot flashes, night sweats, and vaginal dryness. It is a gel that's absorbed through the skin to provide the body with estrogen and treat moderate to severe menopausal symptoms.
On average, the cost of Divigel is $446.22 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. However, you can reduce this cost by using SingleCare's free discount card or the Divigel coupons that you'll find here. Pay just $35.58 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box when you use your Divigel coupons at any of the participating pharmacies in the United States.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Divigel Retail Price | Estradiol Retail Price | Estradiol SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | - | $171.90 | $55.72 |
| Walmart | - | $170.40 | $131.92 |
| Walgreens | $216.90 | $133.62 | $75.60 |
| Kroger Pharmacy | $202.50 | $189.60 | $83.10 |
| Albertsons Pharmacy | - | $162.60 | $105.60 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
The FDA has approved Divigel (estradiol gel) to treat certain symptoms of menopause including hot flashes, night sweats, and vaginal dryness. It is a gel that's absorbed through the skin to provide the body with estrogen and treat moderate to severe menopausal symptoms.
On average, the cost of Divigel is $446.22 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. However, you can reduce this cost by using SingleCare's free discount card or the Divigel coupons that you'll find here. Pay just $35.58 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box when you use your Divigel coupons at any of the participating pharmacies in the United States.
Without insurance, Divigel can cost users around $446.22 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. You can, however, save on your Divigel cost by using SingleCare's Divigel coupon to pay only $35.58 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. In fact, SingleCare users can save up to 80% on their prescription drug prices. Ask your local pharmacist to run your SingleCare savings card and compare Divigel prices before you overpay for your next refill.
Generally, Divigel is not a drug that is covered by most Medicare and insurance plans. You can save on your Divigel cost by using SingleCare, which brings your Divigel price down to $35.58 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. To activate these discounts, visit your local drugstore and discuss payment options with your pharmacist.
Always request the retail price of a prescription medication. Surprisingly, the cash price of a drug could already be lower than your copay amount with insurance. Apply a coupon on top of that cash price to get maximum savings on Divigel.
Divigel is not typically covered by Medicare. You can, however, contact your healthcare plan provider for more information on the copay with your insurance. To get a discount on your Divigel prescription, you can use SingleCare and pay as little as $35.58 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. SingleCare savings card users can save up to 80% on their drug prices, so you can also receive savings on the rest of your family's prescriptions.
There is no generic version of Divigel. It is only available as a brand-name drug. Although generic drugs are usually more affordable than brand-name drugs, you can still search SingleCare for prescription discounts on both generic and brand-name products.
Divigel is a clear, colorless, and odorless gel that contains estradiol. Estradiol is an estrogen steroid hormone, which also functions as the major female sex hormone. It is involved in the management of menstrual cycles in women. During menopause, the ovaries make less of this hormone, leading to symptoms like hot flashes and vaginal dryness, burning, and irritation.
Divigel is a prescription-only drug. It is applied to your upper thigh and absorbed into the skin. Estradiol then enters the bloodstream to help reduce hot flashes, vaginal dryness, and mood changes. Divigel administers lower doses of estradiol than other hormone replacement therapies. It is available in packets containing 0.25, 0.5, 0.75, and 1.0 g of estradiol, which translates to 0.25 mg, 0.5 mg, 0.75 mg, 1.0 mg and 1.25 mg of estradiol per day, respectively.
Side effects that tend to accompany the use of Divigel include nausea or vomiting, bloating, breast pain and tenderness, headache, and weight changes. More side effects may occur. These include, but are not limited to, irregular vaginal bleeding or spotting, vaginal yeast infections, and upper respiratory tract infections. This list does not include all possible side effects so talk to your healthcare provider before using Divigel.
Estrogen therapy should not be used if you have ever had a history of breast cancer. Estrogen therapy may increase the risk of endometrial cancer or breast cancer. It’s also important to tell your doctor if you have ever had a history of blood clots, such as deep vein thrombosis (DVT) or pulmonary embolism (PE). Estrogen treatment may increase the risk of blood clots, stroke, or heart attack in some women. Consult your healthcare provider for other possible warnings and precautions associated with Divigel.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved