The FDA has approved Divigel (estradiol gel) to treat certain symptoms of menopause including hot flashes, night sweats, and vaginal dryness. It is a gel that's absorbed through the skin to provide the body with estrogen and treat moderate to severe menopausal symptoms.
On average, the cost of Divigel is $437.33 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. However, you can reduce this cost by using SingleCare's free discount card or the Divigel coupons that you'll find here. Pay just $34.96 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box when you use your Divigel coupons at any of the participating pharmacies in the United States.
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Los precios de los medicamentos recetados de SingleCare se basan en diversas fuentes. Los precios que publicamos son nuestra mejor estimación, pero no podemos garantizar que el precio que mostramos coincida exactamente con el precio que recibes en la farmacia. Para saber el precio exacto, por favor, comunícate con tu farmacia y proporciona los números BIN/GRP/PCN que aparecen en tu tarjeta de SingleCare.
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Precios actualizados: 03/08/2026
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The FDA has approved Divigel (estradiol gel) to treat certain symptoms of menopause including hot flashes, night sweats, and vaginal dryness. It is a gel that's absorbed through the skin to provide the body with estrogen and treat moderate to severe menopausal symptoms.
On average, the cost of Divigel is $437.33 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. However, you can reduce this cost by using SingleCare's free discount card or the Divigel coupons that you'll find here. Pay just $34.96 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box when you use your Divigel coupons at any of the participating pharmacies in the United States.
Nuestras métricas de historial de precios son calculadas a partir de datos agregados de las recetas médicas que recibimos de todas las farmacias participantes. Esta tabla se actualiza diariamente para mostrar las nuevas variaciones en los precios. Si falta un punto de datos en la tabla, es porque no contamos con suficiente información para producir una cifra confiable.
| Farmacia | Precio minorista de Divigel | Precio minorista de Estradiol | Precio de Estradiol en SingleCare |
|---|---|---|---|
| CVS Pharmacy | $201.90 | $38.70 | $31.80 |
| Walmart | $197.10 | $130.52 | $88.89 |
| Walgreens | $216.90 | $104.54 | $65.40 |
| Kroger Pharmacy | $222.60 | $189.60 | $83.10 |
| Albertsons Pharmacy | $210.60 | $173.70 | $105.60 |
Estos precios se basan en los datos del último mes de surtidos de recetas de SingleCare en las principales farmacias. Esta tabla se actualiza diariamente para mostrar los precios típicos más precisos por farmacia. Si falta algún dato en la tabla, es porque no contamos con suficiente información para generar una cifra confiable.
The FDA has approved Divigel (estradiol gel) to treat certain symptoms of menopause including hot flashes, night sweats, and vaginal dryness. It is a gel that's absorbed through the skin to provide the body with estrogen and treat moderate to severe menopausal symptoms.
On average, the cost of Divigel is $437.33 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. However, you can reduce this cost by using SingleCare's free discount card or the Divigel coupons that you'll find here. Pay just $34.96 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box when you use your Divigel coupons at any of the participating pharmacies in the United States.
Without insurance, Divigel can cost users around $437.33 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. You can, however, save on your Divigel cost by using SingleCare's Divigel coupon to pay only $34.96 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. In fact, SingleCare users can save up to 80% on their prescription drug prices. Ask your local pharmacist to run your SingleCare savings card and compare Divigel prices before you overpay for your next refill.
Generally, Divigel is not a drug that is covered by most Medicare and insurance plans. You can save on your Divigel cost by using SingleCare, which brings your Divigel price down to $34.96 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. To activate these discounts, visit your local drugstore and discuss payment options with your pharmacist.
Always request the retail price of a prescription medication. Surprisingly, the cash price of a drug could already be lower than your copay amount with insurance. Apply a coupon on top of that cash price to get maximum savings on Divigel.
Divigel is not typically covered by Medicare. You can, however, contact your healthcare plan provider for more information on the copay with your insurance. To get a discount on your Divigel prescription, you can use SingleCare and pay as little as $34.96 for 1, 1 box (30 gel packets), 0.5mg/0.5gm (0.1%) box of Divigel. SingleCare savings card users can save up to 80% on their drug prices, so you can also receive savings on the rest of your family's prescriptions.
There is no generic version of Divigel. It is only available as a brand-name drug. Although generic drugs are usually more affordable than brand-name drugs, you can still search SingleCare for prescription discounts on both generic and brand-name products.
Divigel is a clear, colorless, and odorless gel that contains estradiol. Estradiol is an estrogen steroid hormone, which also functions as the major female sex hormone. It is involved in the management of menstrual cycles in women. During menopause, the ovaries make less of this hormone, leading to symptoms like hot flashes and vaginal dryness, burning, and irritation.
Divigel is a prescription-only drug. It is applied to your upper thigh and absorbed into the skin. Estradiol then enters the bloodstream to help reduce hot flashes, vaginal dryness, and mood changes. Divigel administers lower doses of estradiol than other hormone replacement therapies. It is available in packets containing 0.25, 0.5, 0.75, and 1.0 g of estradiol, which translates to 0.25 mg, 0.5 mg, 0.75 mg, 1.0 mg and 1.25 mg of estradiol per day, respectively.
Side effects that tend to accompany the use of Divigel include nausea or vomiting, bloating, breast pain and tenderness, headache, and weight changes. More side effects may occur. These include, but are not limited to, irregular vaginal bleeding or spotting, vaginal yeast infections, and upper respiratory tract infections. This list does not include all possible side effects so talk to your healthcare provider before using Divigel.
Estrogen therapy should not be used if you have ever had a history of breast cancer. Estrogen therapy may increase the risk of endometrial cancer or breast cancer. It’s also important to tell your doctor if you have ever had a history of blood clots, such as deep vein thrombosis (DVT) or pulmonary embolism (PE). Estrogen treatment may increase the risk of blood clots, stroke, or heart attack in some women. Consult your healthcare provider for other possible warnings and precautions associated with Divigel.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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