Depo-Estradiol is a brand-name intramuscular injection that contains estradiol cypionate. It is prescribed to menopausal women to alleviate moderate to severe vasomotor symptoms, such as hot flashes, night sweats, and flushing. It is also prescribed to women who have a deficiency in estrogen production or as hormonal therapy for transgender women. The average cash price of Depo-Estradiol is $297.15 for 1, 5ml of 5mg/ml vial, but you can get a discount with a SingleCare Depo-Estradiol coupon. Ask the clinic or hospital where you receive Depo-Estradiol injections if they will accept a SingleCare Depo-Estradiol coupon; you could pay only $242.25 for 1, 5ml of 5mg/ml vial.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Depo-Estradiol is a brand-name intramuscular injection that contains estradiol cypionate. It is prescribed to menopausal women to alleviate moderate to severe vasomotor symptoms, such as hot flashes, night sweats, and flushing. It is also prescribed to women who have a deficiency in estrogen production or as hormonal therapy for transgender women. The average cash price of Depo-Estradiol is $297.15 for 1, 5ml of 5mg/ml vial, but you can get a discount with a SingleCare Depo-Estradiol coupon. Ask the clinic or hospital where you receive Depo-Estradiol injections if they will accept a SingleCare Depo-Estradiol coupon; you could pay only $242.25 for 1, 5ml of 5mg/ml vial.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Depo-Estradiol Retail Price | Depo-Estradiol SingleCare Price |
|---|---|---|
| CVS Pharmacy | $293.00 | $275.45 |
| Walmart | $294.90 | $263.45 |
| Walgreens | $315.00 | $262.65 |
| Kroger Pharmacy | $310.50 | $245.25 |
| Albertsons Pharmacy | $304.70 | $265.45 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Depo-Estradiol is a brand-name intramuscular injection that contains estradiol cypionate. It is prescribed to menopausal women to alleviate moderate to severe vasomotor symptoms, such as hot flashes, night sweats, and flushing. It is also prescribed to women who have a deficiency in estrogen production or as hormonal therapy for transgender women. The average cash price of Depo-Estradiol is $297.15 for 1, 5ml of 5mg/ml vial, but you can get a discount with a SingleCare Depo-Estradiol coupon. Ask the clinic or hospital where you receive Depo-Estradiol injections if they will accept a SingleCare Depo-Estradiol coupon; you could pay only $242.25 for 1, 5ml of 5mg/ml vial.
Depo-Estradiol can cost an average cash price of $297.15 for 1, 5ml of 5mg/ml vial for uninsured customers. The actual cash price of Depo-Estradiol can vary depending on the dosage and quantity prescribed. A SingleCare Depo-Estradiol coupon could allow you to pay only $242.25 for 1, 5ml of 5mg/ml vial. Ask the hospital or clinic where you receive Depo-Estradiol injections if they will accept SingleCare as a savings option.
Your copay for Depo-Estradiol with insurance will vary depending on your plan and the dosage required. Check with your insurance provider to determine your coverage for Depo-Estradiol. Depo-Estradiol may be covered by your health insurance as a medical benefit rather than a prescription drug benefit. Ask the clinic or hospital where you receive Depo-Estradiol injections if they will accept a SingleCare Depo-Estradiol coupon; you could pay only $242.25 for 1, 5ml of 5mg/ml vial if they do.
Depo-Estradiol is not usually covered under Medicare Part D and Medicare Advantage prescription drug plans. Instead, it may be covered under Medicare Part B as a medical benefit. If you're not covered, ask the clinic or hospital where you receive Depo-Estradiol injections if they will accept a SingleCare Depo-Estradiol coupon; you could pay only $242.25 for 1, 5ml of 5mg/ml vial.
Depo-Estradiol is a brand-name injection. The generic name of Depo-Estradiol is estradiol cypionate. There may not be a generic version of Depo-Estradiol currently available.
Depo-Estradiol is a brand-name intramuscular injection that contains estradiol cypionate. It is prescribed to treat vasomotor symptoms caused by menopause, such as hot flashes, night sweats, and flushing. Depo-Estradiol may also help alleviate other symptoms of menopause, such as vaginal dryness.
Depo-Estradiol is approved for women whose ovaries have stopped producing or produce too little estrogen. Depo-Estradiol is sometimes used off-label as hormonal therapy for transgender women.
Depo-Estradiol is administered as an injection by a healthcare professional once every 3 to 4 weeks. Consult with a healthcare provider to determine the appropriate dosage for you. The dosage can vary depending on the condition being treated.
The most common side effects of Depo-Estradiol include headache, bloating, stomach cramps, breast tenderness, irregular vaginal bleeding or spotting, and nausea or vomiting. Other side effects may include fluid retention, high blood pressure, high blood sugar levels, liver problems, uterine fibroids, vaginal yeast infections, and hair loss.
Serious side effects include stroke, heart attack, breast cancer, and blood clots. Women who are 65 or older may be at an increased risk of developing dementia. Allergic reactions are uncommon but may include symptoms like rash, hives, or trouble breathing. Immediately seek medical attention if you show signs of an allergic reaction.
This is not a complete list of side effects. Consult with a healthcare provider about other possible side effects, warnings, and precautions associated with Depo-Estradiol. Tell your doctor about other medical conditions you have and other medications you may be taking before starting treatment with Depo-Estradiol.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved